Engineered Biomimetic Fibrillar Fibronectin Matrices Regulate Cell Adhesion Initiation, Migration, and Proliferation via α5β1 Integrin and Syndecan‐4 Crosstalk

Engineered Biomimetic Fibrillar Fibronectin Matrices Regulate Cell Adhesion Initiation, Migration, and Proliferation via α5β1 Integrin and Syndecan‐4 Crosstalk

Abstract Cells regulate adhesion to the fibrillar extracellular matrix (ECM) of which fibronectin is an essential component. However, most studies characterize cell adhesion to globular fibronectin substrates at time scales long after cells polarize and migrate. To overcome this limitation, a simple...

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Bibliographic Details
Main Authors: Seungkuk Ahn, Upnishad Sharma, Krishna Chaitanya Kasuba, Nico Strohmeyer, Daniel J. Müller
Format: Article
Language:English
Published: Wiley 2023-08-01
Series:Advanced Science
Subjects:
3D fibrillar fibronectin
adhesion initiation
extracellular matrix
integrin
spatiotemporal cell dynamics
syndecan
Online Access:https://doi.org/10.1002/advs.202300812

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