Perfusion device for liver preservation ex vivo before transplantation: first experimental study
Introduction. Successful liver transplantation including from donors with a sudden irreversible cardiac arrest requires the use of modern hardware and technical support to maintain, select and sustain organ viability for the period from harvesting to transplantation to the recipient.Materials and me...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov
2017-04-01
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| Series: | Vestnik Transplantologii i Iskusstvennyh Organov |
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| Online Access: | https://journal.transpl.ru/vtio/article/view/730 |
| _version_ | 1797871984399351808 |
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| author | O. N. Reznik A. E. Skvortsov A. V. Lopota N. A. Gryaznov V. V. Kharlamov G. S. Kireeva |
| author_facet | O. N. Reznik A. E. Skvortsov A. V. Lopota N. A. Gryaznov V. V. Kharlamov G. S. Kireeva |
| author_sort | O. N. Reznik |
| collection | DOAJ |
| description | Introduction. Successful liver transplantation including from donors with a sudden irreversible cardiac arrest requires the use of modern hardware and technical support to maintain, select and sustain organ viability for the period from harvesting to transplantation to the recipient.Materials and methods. Hardware-software system (HSS) developed by the Russian State Scientific Center for Robotics and Technical Cybernetics (RTC) was used for testing of normothermic perfusion of donor’s liver ex vivo. The experiment was conducted on the isolated pig liver (Duroc breed) in accordance with the ethical principles.Result. During perfusion spontaneous recovery of bile outflow through the cannula installed in the common bile duct (volume of bile released – 240 ml) was observed, and the color and uniformity of the perfused liver did not differ from the normal parameters. Biochemical indicators were stabilized at the physiological values after 40 minutes of perfusion procedure.Conclusion. Isolated liver transplant was completely restored after 30 minutes of warm ischemia and was functioning well due to ex vivo perfusion procedure on the new perfusion device. The first case of the new device usage for normothermic liver ex vivo demonstrated hopeful results to be further investigated. |
| first_indexed | 2024-04-10T00:52:42Z |
| format | Article |
| id | doaj.art-2bc796fd96f548a6a8a1680374ad2397 |
| institution | Directory Open Access Journal |
| issn | 1995-1191 |
| language | Russian |
| last_indexed | 2024-04-10T00:52:42Z |
| publishDate | 2017-04-01 |
| publisher | Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov |
| record_format | Article |
| series | Vestnik Transplantologii i Iskusstvennyh Organov |
| spelling | doaj.art-2bc796fd96f548a6a8a1680374ad23972023-03-13T10:37:24ZrusFederal Research Center of Transplantology and Artificial Organs named after V.I.ShumakovVestnik Transplantologii i Iskusstvennyh Organov1995-11912017-04-01191354010.15825/1995-1191-2017-1-35-40602Perfusion device for liver preservation ex vivo before transplantation: first experimental studyO. N. Reznik0A. E. Skvortsov1A. V. Lopota2N. A. Gryaznov3V. V. Kharlamov4G. S. Kireeva5Pavlov First Saint Petersburg State Medical University Russian State Scientific Center for Robotics and Technical Cybernetics Saint-Petersburg I.I. Dzhanelidze Research Institute of Emergency MedicinePavlov First Saint Petersburg State Medical University Russian State Scientific Center for Robotics and Technical CyberneticsRussian State Scientific Center for Robotics and Technical CyberneticsRussian State Scientific Center for Robotics and Technical CyberneticsRussian State Scientific Center for Robotics and Technical CyberneticsRussian State Scientific Center for Robotics and Technical CyberneticsIntroduction. Successful liver transplantation including from donors with a sudden irreversible cardiac arrest requires the use of modern hardware and technical support to maintain, select and sustain organ viability for the period from harvesting to transplantation to the recipient.Materials and methods. Hardware-software system (HSS) developed by the Russian State Scientific Center for Robotics and Technical Cybernetics (RTC) was used for testing of normothermic perfusion of donor’s liver ex vivo. The experiment was conducted on the isolated pig liver (Duroc breed) in accordance with the ethical principles.Result. During perfusion spontaneous recovery of bile outflow through the cannula installed in the common bile duct (volume of bile released – 240 ml) was observed, and the color and uniformity of the perfused liver did not differ from the normal parameters. Biochemical indicators were stabilized at the physiological values after 40 minutes of perfusion procedure.Conclusion. Isolated liver transplant was completely restored after 30 minutes of warm ischemia and was functioning well due to ex vivo perfusion procedure on the new perfusion device. The first case of the new device usage for normothermic liver ex vivo demonstrated hopeful results to be further investigated.https://journal.transpl.ru/vtio/article/view/730liver transplantationnormothermic perfusionhardware-software system |
| spellingShingle | O. N. Reznik A. E. Skvortsov A. V. Lopota N. A. Gryaznov V. V. Kharlamov G. S. Kireeva Perfusion device for liver preservation ex vivo before transplantation: first experimental study Vestnik Transplantologii i Iskusstvennyh Organov liver transplantation normothermic perfusion hardware-software system |
| title | Perfusion device for liver preservation ex vivo before transplantation: first experimental study |
| title_full | Perfusion device for liver preservation ex vivo before transplantation: first experimental study |
| title_fullStr | Perfusion device for liver preservation ex vivo before transplantation: first experimental study |
| title_full_unstemmed | Perfusion device for liver preservation ex vivo before transplantation: first experimental study |
| title_short | Perfusion device for liver preservation ex vivo before transplantation: first experimental study |
| title_sort | perfusion device for liver preservation ex vivo before transplantation first experimental study |
| topic | liver transplantation normothermic perfusion hardware-software system |
| url | https://journal.transpl.ru/vtio/article/view/730 |
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