The Roles of CCCH Zinc-Finger Proteins in Plant Abiotic Stress Tolerance
Zinc-finger proteins, a superfamily of proteins with a typical structural domain that coordinates a zinc ion and binds nucleic acids, participate in the regulation of growth, development, and stress adaptation in plants. Most zinc fingers are C2H2-type or CCCC-type, named after the configuration of...
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MDPI AG
2021-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/15/8327 |
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| author | Guoliang Han Ziqi Qiao Yuxia Li Chengfeng Wang Baoshan Wang |
| author_facet | Guoliang Han Ziqi Qiao Yuxia Li Chengfeng Wang Baoshan Wang |
| author_sort | Guoliang Han |
| collection | DOAJ |
| description | Zinc-finger proteins, a superfamily of proteins with a typical structural domain that coordinates a zinc ion and binds nucleic acids, participate in the regulation of growth, development, and stress adaptation in plants. Most zinc fingers are C2H2-type or CCCC-type, named after the configuration of cysteine (C) and histidine (H); the less-common CCCH zinc-finger proteins are important in the regulation of plant stress responses. In this review, we introduce the domain structures, classification, and subcellular localization of CCCH zinc-finger proteins in plants and discuss their functions in transcriptional and post-transcriptional regulation via interactions with DNA, RNA, and other proteins. We describe the functions of CCCH zinc-finger proteins in plant development and tolerance to abiotic stresses such as salt, drought, flooding, cold temperatures and oxidative stress. Finally, we summarize the signal transduction pathways and regulatory networks of CCCH zinc-finger proteins in their responses to abiotic stress. CCCH zinc-finger proteins regulate the adaptation of plants to abiotic stress in various ways, but the specific molecular mechanisms need to be further explored, along with other mechanisms such as cytoplasm-to-nucleus shuttling and post-transcriptional regulation. Unraveling the molecular mechanisms by which CCCH zinc-finger proteins improve stress tolerance will facilitate the breeding and genetic engineering of crops with improved traits. |
| first_indexed | 2024-03-10T09:13:45Z |
| format | Article |
| id | doaj.art-2bc85810bf3a449097a53cd2effb2898 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T09:13:45Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-2bc85810bf3a449097a53cd2effb28982023-11-22T05:46:48ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-08-012215832710.3390/ijms22158327The Roles of CCCH Zinc-Finger Proteins in Plant Abiotic Stress ToleranceGuoliang Han0Ziqi Qiao1Yuxia Li2Chengfeng Wang3Baoshan Wang4Shandong Provincial Key Laboratory of Plant Stress, College of Life Science, Shandong Normal University, Ji’nan 250014, ChinaShandong Provincial Key Laboratory of Plant Stress, College of Life Science, Shandong Normal University, Ji’nan 250014, ChinaShandong Provincial Key Laboratory of Plant Stress, College of Life Science, Shandong Normal University, Ji’nan 250014, ChinaShandong Provincial Key Laboratory of Plant Stress, College of Life Science, Shandong Normal University, Ji’nan 250014, ChinaShandong Provincial Key Laboratory of Plant Stress, College of Life Science, Shandong Normal University, Ji’nan 250014, ChinaZinc-finger proteins, a superfamily of proteins with a typical structural domain that coordinates a zinc ion and binds nucleic acids, participate in the regulation of growth, development, and stress adaptation in plants. Most zinc fingers are C2H2-type or CCCC-type, named after the configuration of cysteine (C) and histidine (H); the less-common CCCH zinc-finger proteins are important in the regulation of plant stress responses. In this review, we introduce the domain structures, classification, and subcellular localization of CCCH zinc-finger proteins in plants and discuss their functions in transcriptional and post-transcriptional regulation via interactions with DNA, RNA, and other proteins. We describe the functions of CCCH zinc-finger proteins in plant development and tolerance to abiotic stresses such as salt, drought, flooding, cold temperatures and oxidative stress. Finally, we summarize the signal transduction pathways and regulatory networks of CCCH zinc-finger proteins in their responses to abiotic stress. CCCH zinc-finger proteins regulate the adaptation of plants to abiotic stress in various ways, but the specific molecular mechanisms need to be further explored, along with other mechanisms such as cytoplasm-to-nucleus shuttling and post-transcriptional regulation. Unraveling the molecular mechanisms by which CCCH zinc-finger proteins improve stress tolerance will facilitate the breeding and genetic engineering of crops with improved traits.https://www.mdpi.com/1422-0067/22/15/8327abiotic stressesCCCH zinc-finger proteinsplantsregulation pathwaystranscription factor |
| spellingShingle | Guoliang Han Ziqi Qiao Yuxia Li Chengfeng Wang Baoshan Wang The Roles of CCCH Zinc-Finger Proteins in Plant Abiotic Stress Tolerance International Journal of Molecular Sciences abiotic stresses CCCH zinc-finger proteins plants regulation pathways transcription factor |
| title | The Roles of CCCH Zinc-Finger Proteins in Plant Abiotic Stress Tolerance |
| title_full | The Roles of CCCH Zinc-Finger Proteins in Plant Abiotic Stress Tolerance |
| title_fullStr | The Roles of CCCH Zinc-Finger Proteins in Plant Abiotic Stress Tolerance |
| title_full_unstemmed | The Roles of CCCH Zinc-Finger Proteins in Plant Abiotic Stress Tolerance |
| title_short | The Roles of CCCH Zinc-Finger Proteins in Plant Abiotic Stress Tolerance |
| title_sort | roles of ccch zinc finger proteins in plant abiotic stress tolerance |
| topic | abiotic stresses CCCH zinc-finger proteins plants regulation pathways transcription factor |
| url | https://www.mdpi.com/1422-0067/22/15/8327 |
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