Immuno-modulatory and anti-inflammatory effects of Thymus vulgaris, Zataria multiflora, and Portulaca oleracea and their constituents
Medicinal herbs are widely used in the both traditional and modern medicines. Thymus vulgaris (T. vulgaris), Zataria multiflora (Z. multiflora), and Portulaca oleracea (P. oleracea) have been traditionally known as medicinal herbs. In this article, immune-modulatory effects of T.s vulgaris, Z. multi...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-12-01
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| Series: | Pharmacological Research - Modern Chinese Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667142521000099 |
| _version_ | 1798035237880463360 |
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| author | Mohammad Reza Khazdair Zahra Gholamnezhad Ramin Rezaee Mohammad Hossein Boskabady |
| author_facet | Mohammad Reza Khazdair Zahra Gholamnezhad Ramin Rezaee Mohammad Hossein Boskabady |
| author_sort | Mohammad Reza Khazdair |
| collection | DOAJ |
| description | Medicinal herbs are widely used in the both traditional and modern medicines. Thymus vulgaris (T. vulgaris), Zataria multiflora (Z. multiflora), and Portulaca oleracea (P. oleracea) have been traditionally known as medicinal herbs. In this article, immune-modulatory effects of T.s vulgaris, Z. multiflora, and P. oleracea and their constituents, are reviewed. To this end, relevant articles, books, and conference papers published in English, until the end of September 2020, were retrieved from Web of Science, PubMed, Scopus and Google Scholar databases. Based on the literature, T. vulgaris and thymol reduced IL-6, IL- 1β and tumor necrosis factor α (TNFα) at both gene and proteins levels. Z. multiflora and carvacrol increased serum levels of IFN-γ but reduced IL-4 levels. P. oleracea and quercetin decreased T helper 2 (Th2)/Th1 and Th2/ regulatory T cells (Tregs) ratios by inducing IL-10 but suppression of IL-4. Together, these medicinal plants might be considered for the treatment of conditions associated with immune-dysregulation such as asthma and cancer. |
| first_indexed | 2024-04-11T20:55:26Z |
| format | Article |
| id | doaj.art-2bc8b2ddccb44a20a35fca165343e6d4 |
| institution | Directory Open Access Journal |
| issn | 2667-1425 |
| language | English |
| last_indexed | 2024-04-11T20:55:26Z |
| publishDate | 2021-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research - Modern Chinese Medicine |
| spelling | doaj.art-2bc8b2ddccb44a20a35fca165343e6d42022-12-22T04:03:42ZengElsevierPharmacological Research - Modern Chinese Medicine2667-14252021-12-011100010Immuno-modulatory and anti-inflammatory effects of Thymus vulgaris, Zataria multiflora, and Portulaca oleracea and their constituentsMohammad Reza Khazdair0Zahra Gholamnezhad1Ramin Rezaee2Mohammad Hossein Boskabady3Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran; Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, IranApplied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranApplied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Clinical Research Unit, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranApplied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Corresponding author.Medicinal herbs are widely used in the both traditional and modern medicines. Thymus vulgaris (T. vulgaris), Zataria multiflora (Z. multiflora), and Portulaca oleracea (P. oleracea) have been traditionally known as medicinal herbs. In this article, immune-modulatory effects of T.s vulgaris, Z. multiflora, and P. oleracea and their constituents, are reviewed. To this end, relevant articles, books, and conference papers published in English, until the end of September 2020, were retrieved from Web of Science, PubMed, Scopus and Google Scholar databases. Based on the literature, T. vulgaris and thymol reduced IL-6, IL- 1β and tumor necrosis factor α (TNFα) at both gene and proteins levels. Z. multiflora and carvacrol increased serum levels of IFN-γ but reduced IL-4 levels. P. oleracea and quercetin decreased T helper 2 (Th2)/Th1 and Th2/ regulatory T cells (Tregs) ratios by inducing IL-10 but suppression of IL-4. Together, these medicinal plants might be considered for the treatment of conditions associated with immune-dysregulation such as asthma and cancer.http://www.sciencedirect.com/science/article/pii/S2667142521000099Thymus vulgarisZataria multifloraPortulaca oleraceaConstituentsImmuno-modulationCytokines |
| spellingShingle | Mohammad Reza Khazdair Zahra Gholamnezhad Ramin Rezaee Mohammad Hossein Boskabady Immuno-modulatory and anti-inflammatory effects of Thymus vulgaris, Zataria multiflora, and Portulaca oleracea and their constituents Pharmacological Research - Modern Chinese Medicine Thymus vulgaris Zataria multiflora Portulaca oleracea Constituents Immuno-modulation Cytokines |
| title | Immuno-modulatory and anti-inflammatory effects of Thymus vulgaris, Zataria multiflora, and Portulaca oleracea and their constituents |
| title_full | Immuno-modulatory and anti-inflammatory effects of Thymus vulgaris, Zataria multiflora, and Portulaca oleracea and their constituents |
| title_fullStr | Immuno-modulatory and anti-inflammatory effects of Thymus vulgaris, Zataria multiflora, and Portulaca oleracea and their constituents |
| title_full_unstemmed | Immuno-modulatory and anti-inflammatory effects of Thymus vulgaris, Zataria multiflora, and Portulaca oleracea and their constituents |
| title_short | Immuno-modulatory and anti-inflammatory effects of Thymus vulgaris, Zataria multiflora, and Portulaca oleracea and their constituents |
| title_sort | immuno modulatory and anti inflammatory effects of thymus vulgaris zataria multiflora and portulaca oleracea and their constituents |
| topic | Thymus vulgaris Zataria multiflora Portulaca oleracea Constituents Immuno-modulation Cytokines |
| url | http://www.sciencedirect.com/science/article/pii/S2667142521000099 |
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