Processing of progranulin into granulins involves multiple lysosomal proteases and is affected in frontotemporal lobar degeneration

Processing of progranulin into granulins involves multiple lysosomal proteases and is affected in frontotemporal lobar degeneration

Abstract Background Progranulin loss-of-function mutations are linked to frontotemporal lobar degeneration with TDP-43 positive inclusions (FTLD-TDP-Pgrn). Progranulin (PGRN) is an intracellular and secreted pro-protein that is proteolytically cleaved into individual granulin peptides, which are inc...

Bibliografiset tiedot
Päätekijät:	Swetha Mohan, Paul J. Sampognaro, Andrea R. Argouarch, Jason C. Maynard, Mackenzie Welch, Anand Patwardhan, Emma C. Courtney, Jiasheng Zhang, Amanda Mason, Kathy H. Li, Eric J. Huang, William W. Seeley, Bruce L. Miller, Alma Burlingame, Mathew P. Jacobson, Aimee W. Kao
Aineistotyyppi:	Artikkeli
Kieli:	English
Julkaistu:	BMC 2021-08-01
Sarja:	Molecular Neurodegeneration
Aiheet:	Progranulin Granulin Frontotemporal lobar degeneration Lysosome Protease pH
Linkit:	https://doi.org/10.1186/s13024-021-00472-1

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