The effect of deworming on early childhood development in Peru: A randomized controlled trial
Background: There is a knowledge gap on the effect of early childhood deworming on development in low- and middle-income countries. This evidence is important in the critical window of growth and development before two years of age. Methods: A randomized controlled trial of the benefit, and optimal...
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| Format: | Article |
| Language: | English |
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Elsevier
2015-12-01
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| Series: | SSM: Population Health |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S235282731500004X |
| _version_ | 1811326133839331328 |
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| author | Serene A. Joseph Martín Casapía Fabiola Lazarte Elham Rahme Lidsky Pezo Brittany Blouin Theresa W. Gyorkos |
| author_facet | Serene A. Joseph Martín Casapía Fabiola Lazarte Elham Rahme Lidsky Pezo Brittany Blouin Theresa W. Gyorkos |
| author_sort | Serene A. Joseph |
| collection | DOAJ |
| description | Background: There is a knowledge gap on the effect of early childhood deworming on development in low- and middle-income countries. This evidence is important in the critical window of growth and development before two years of age.
Methods: A randomized controlled trial of the benefit, and optimal timing and frequency, of deworming on development was conducted in Iquitos, Peru. Children were enrolled during routine 12-month growth and development visits and randomly allocated to: (1) deworming at the 12-month visit and placebo at the 18-month visit; (2) placebo at the 12-month visit and deworming at the 18-month visit; (3) deworming at the 12 and 18-month visits; or (4) placebo at the 12 and 18-month visits. The Bayley Scales of Infant Development III was used to assess cognitive, language and motor skills at the 12 and 24-month visits. One-way ANOVA analyses used an intention-to-treat approach.
Results: Between September 2011 and June 2012, 1760 children were enrolled. Attendance at the 24-month visit was 88.8% (n=1563). Raw scores on all subtests increased over 12 months; however, cognitive and expressive language scaled scores decreased. There was no statistically significant benefit of deworming, or effect of timing or frequency, on any of the development scores. Baseline height and weight and maternal education were associated with development scores at 24 months.
Conclusions: After 12 months of follow-up, an overall benefit of deworming on cognition, language or fine motor development was not detected. Additional integrated child and maternal interventions should be considered to prevent developmental deficits in this critical period. |
| first_indexed | 2024-04-13T14:44:57Z |
| format | Article |
| id | doaj.art-2bcd1603d450492f989490c61a361aac |
| institution | Directory Open Access Journal |
| issn | 2352-8273 |
| language | English |
| last_indexed | 2024-04-13T14:44:57Z |
| publishDate | 2015-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | SSM: Population Health |
| spelling | doaj.art-2bcd1603d450492f989490c61a361aac2022-12-22T02:42:47ZengElsevierSSM: Population Health2352-82732015-12-011C323910.1016/j.ssmph.2015.10.001The effect of deworming on early childhood development in Peru: A randomized controlled trialSerene A. Joseph0Martín Casapía1Fabiola Lazarte2Elham Rahme3Lidsky Pezo4Brittany Blouin5Theresa W. Gyorkos6McGill University, Department of Epidemiology, Biostatistics and Occupational Health, Montréal, Québec, CanadaAsociación Civil Selva Amazónica, Iquitos, PeruInstituto de Investigación Nutricional, Lima, PeruResearch Institute of the McGill University Health Centre, Division of Clinical Epidemiology, Montréal, Québec, CanadaAsociación Civil Selva Amazónica, Iquitos, PeruMcGill University, Department of Epidemiology, Biostatistics and Occupational Health, Montréal, Québec, CanadaMcGill University, Department of Epidemiology, Biostatistics and Occupational Health, Montréal, Québec, CanadaBackground: There is a knowledge gap on the effect of early childhood deworming on development in low- and middle-income countries. This evidence is important in the critical window of growth and development before two years of age. Methods: A randomized controlled trial of the benefit, and optimal timing and frequency, of deworming on development was conducted in Iquitos, Peru. Children were enrolled during routine 12-month growth and development visits and randomly allocated to: (1) deworming at the 12-month visit and placebo at the 18-month visit; (2) placebo at the 12-month visit and deworming at the 18-month visit; (3) deworming at the 12 and 18-month visits; or (4) placebo at the 12 and 18-month visits. The Bayley Scales of Infant Development III was used to assess cognitive, language and motor skills at the 12 and 24-month visits. One-way ANOVA analyses used an intention-to-treat approach. Results: Between September 2011 and June 2012, 1760 children were enrolled. Attendance at the 24-month visit was 88.8% (n=1563). Raw scores on all subtests increased over 12 months; however, cognitive and expressive language scaled scores decreased. There was no statistically significant benefit of deworming, or effect of timing or frequency, on any of the development scores. Baseline height and weight and maternal education were associated with development scores at 24 months. Conclusions: After 12 months of follow-up, an overall benefit of deworming on cognition, language or fine motor development was not detected. Additional integrated child and maternal interventions should be considered to prevent developmental deficits in this critical period.http://www.sciencedirect.com/science/article/pii/S235282731500004XDewormingPreschool-age childrenCognitionLanguageFine motor skillsBayley Scales of Infant DevelopmentLow- and middle-income countriesRandomized controlled trial |
| spellingShingle | Serene A. Joseph Martín Casapía Fabiola Lazarte Elham Rahme Lidsky Pezo Brittany Blouin Theresa W. Gyorkos The effect of deworming on early childhood development in Peru: A randomized controlled trial SSM: Population Health Deworming Preschool-age children Cognition Language Fine motor skills Bayley Scales of Infant Development Low- and middle-income countries Randomized controlled trial |
| title | The effect of deworming on early childhood development in Peru: A randomized controlled trial |
| title_full | The effect of deworming on early childhood development in Peru: A randomized controlled trial |
| title_fullStr | The effect of deworming on early childhood development in Peru: A randomized controlled trial |
| title_full_unstemmed | The effect of deworming on early childhood development in Peru: A randomized controlled trial |
| title_short | The effect of deworming on early childhood development in Peru: A randomized controlled trial |
| title_sort | effect of deworming on early childhood development in peru a randomized controlled trial |
| topic | Deworming Preschool-age children Cognition Language Fine motor skills Bayley Scales of Infant Development Low- and middle-income countries Randomized controlled trial |
| url | http://www.sciencedirect.com/science/article/pii/S235282731500004X |
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