Management of adverse effects of new monoclonal antibody treatments in acute lymphoblastic leukemia
Therapeutic options for relapsed/refractory B-cell acute lymphoblastic leukemia have evolved in the past few years. The FDA has approved three novel therapies for this disease: inotuzumab ozogamicin (an anti-CD22 antibody–drug conjugate), blinatumomab (a bispecific T-cell engager), and chimeric anti...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BioExcel Publishing Ltd
2020-10-01
|
| Series: | Drugs in Context |
| Subjects: | |
| Online Access: | https://www.drugsincontext.com/management-of-adverse-effects-of-new-monoclonal-antibody-treatments-in-acute-lymphoblastic-leukemia |
| _version_ | 1818198741259124736 |
|---|---|
| author | Diego Conde-Royo Luis Miguel Juárez-Salcedo Samir Dalia |
| author_facet | Diego Conde-Royo Luis Miguel Juárez-Salcedo Samir Dalia |
| author_sort | Diego Conde-Royo |
| collection | DOAJ |
| description | Therapeutic options for relapsed/refractory B-cell acute lymphoblastic leukemia have evolved in the past few years. The FDA has approved three novel therapies for this disease: inotuzumab ozogamicin (an anti-CD22 antibody–drug conjugate), blinatumomab (a bispecific T-cell engager), and chimeric antigen receptor T-cell therapy. Although these novel immunotherapies have revolutionized the therapeutic landscape, it is important to understand the crucial aspects of administration, especially toxicity. In this article, we review the unique toxicities and adverse effects of blinatumomab and inotuzumab ozogamicin and provide recommendations for prevention of adverse effects as well as the management options for each medication. |
| first_indexed | 2024-12-12T02:10:41Z |
| format | Article |
| id | doaj.art-2bcd1842e3de4944a966849e55ed66c2 |
| institution | Directory Open Access Journal |
| issn | 1740-4398 1740-4398 |
| language | English |
| last_indexed | 2024-12-12T02:10:41Z |
| publishDate | 2020-10-01 |
| publisher | BioExcel Publishing Ltd |
| record_format | Article |
| series | Drugs in Context |
| spelling | doaj.art-2bcd1842e3de4944a966849e55ed66c22022-12-22T00:41:55ZengBioExcel Publishing LtdDrugs in Context1740-43981740-43982020-10-01911510.7573/dic.2020-7-2Management of adverse effects of new monoclonal antibody treatments in acute lymphoblastic leukemiaDiego Conde-RoyoLuis Miguel Juárez-SalcedoSamir DaliaTherapeutic options for relapsed/refractory B-cell acute lymphoblastic leukemia have evolved in the past few years. The FDA has approved three novel therapies for this disease: inotuzumab ozogamicin (an anti-CD22 antibody–drug conjugate), blinatumomab (a bispecific T-cell engager), and chimeric antigen receptor T-cell therapy. Although these novel immunotherapies have revolutionized the therapeutic landscape, it is important to understand the crucial aspects of administration, especially toxicity. In this article, we review the unique toxicities and adverse effects of blinatumomab and inotuzumab ozogamicin and provide recommendations for prevention of adverse effects as well as the management options for each medication.https://www.drugsincontext.com/management-of-adverse-effects-of-new-monoclonal-antibody-treatments-in-acute-lymphoblastic-leukemiaacute lymphoblastic leukemiaimmunotherapyblinatumomabinotuzumabside effects |
| spellingShingle | Diego Conde-Royo Luis Miguel Juárez-Salcedo Samir Dalia Management of adverse effects of new monoclonal antibody treatments in acute lymphoblastic leukemia Drugs in Context acute lymphoblastic leukemia immunotherapy blinatumomab inotuzumab side effects |
| title | Management of adverse effects of new monoclonal antibody treatments in acute lymphoblastic leukemia |
| title_full | Management of adverse effects of new monoclonal antibody treatments in acute lymphoblastic leukemia |
| title_fullStr | Management of adverse effects of new monoclonal antibody treatments in acute lymphoblastic leukemia |
| title_full_unstemmed | Management of adverse effects of new monoclonal antibody treatments in acute lymphoblastic leukemia |
| title_short | Management of adverse effects of new monoclonal antibody treatments in acute lymphoblastic leukemia |
| title_sort | management of adverse effects of new monoclonal antibody treatments in acute lymphoblastic leukemia |
| topic | acute lymphoblastic leukemia immunotherapy blinatumomab inotuzumab side effects |
| url | https://www.drugsincontext.com/management-of-adverse-effects-of-new-monoclonal-antibody-treatments-in-acute-lymphoblastic-leukemia |
| work_keys_str_mv | AT diegoconderoyo managementofadverseeffectsofnewmonoclonalantibodytreatmentsinacutelymphoblasticleukemia AT luismigueljuarezsalcedo managementofadverseeffectsofnewmonoclonalantibodytreatmentsinacutelymphoblasticleukemia AT samirdalia managementofadverseeffectsofnewmonoclonalantibodytreatmentsinacutelymphoblasticleukemia |