Zinc (II)-Mediated Selective O-Benzylation of 2-Oxo-1,2-Dihydropyridines Systems

Zinc (II)-Mediated Selective O-Benzylation of 2-Oxo-1,2-Dihydropyridines Systems

The selective O-benzylation of 2-oxo-1,2-dihydropyridines plays a critical role in organic synthesis of natural products and biological active molecules. Herein we report a novel ternary system of ZnO, ZnCl2 and N,N-diisopropylethylamine (DIEA), that is highly effective for selective O-benzylation o...

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Bibliographic Details
Main Authors: Qifan Zhou, Fangyu Du, Xinjie Liang, Wenqiang Liu, Ting Fang, Guoliang Chen
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:Molecules
Subjects:
O-benzylation
N-benzylation
2-oxo-1,2-dihydropyridines
zinc (II)
selectivity
Online Access:http://www.mdpi.com/1420-3049/23/7/1784

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