Genomic and epigenomic basis of breast invasive lobular carcinomas lacking CDH1 genetic alterations

Genomic and epigenomic basis of breast invasive lobular carcinomas lacking CDH1 genetic alterations

Abstract CDH1 (E-cadherin) bi-allelic inactivation is the hallmark alteration of breast invasive lobular carcinoma (ILC), resulting in its discohesive phenotype. A subset of ILCs, however, lack CDH1 genetic/epigenetic inactivation, and their genetic underpinning is unknown. Through clinical targeted...

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Bibliographic Details
Main Authors: Higinio Dopeso, Andrea M. Gazzo, Fatemeh Derakhshan, David N. Brown, Pier Selenica, Sahar Jalali, Arnaud Da Cruz Paula, Antonio Marra, Edaise M. da Silva, Thais Basili, Laxmi Gusain, Lorraine Colon-Cartagena, Shirin Issa Bhaloo, Hunter Green, Chad Vanderbilt, Steffi Oesterreich, Anne Grabenstetter, M. Gabriela Kuba, Dara Ross, Dilip Giri, Hannah Y. Wen, Hong Zhang, Edi Brogi, Britta Weigelt, Fresia Pareja, Jorge S. Reis-Filho
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-024-00508-x

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