Milling Positive Master for Polydimethylsiloxane Microfluidic Devices: The Microfabrication and Roughness Issues
We provide a facile and low-cost method (F-L) to fabricate a two-dimensional positive master using a milling technique for polydimethylsiloxane (PDMS)-based microchannel molding. This method comprises the following steps: (1) a positive microscale master of the geometry is milled on to an acrylic bl...
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-09-01
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| Series: | Micromachines |
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| Online Access: | https://www.mdpi.com/2072-666X/8/10/287 |
| _version_ | 1818382755791110144 |
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| author | Zhizhi Zhou Dong Chen Xiang Wang Jiahuan Jiang |
| author_facet | Zhizhi Zhou Dong Chen Xiang Wang Jiahuan Jiang |
| author_sort | Zhizhi Zhou |
| collection | DOAJ |
| description | We provide a facile and low-cost method (F-L) to fabricate a two-dimensional positive master using a milling technique for polydimethylsiloxane (PDMS)-based microchannel molding. This method comprises the following steps: (1) a positive microscale master of the geometry is milled on to an acrylic block; (2) pre-cured PDMS is used to mold the microscale positive master; (3) the PDMS plate is peeled off from the master and punctured with a blunt needle; and (4) the PDMS plate is O2 plasma bonded to a glass slide. Using this technique, we can fabricate microchannels with very simple protocols quickly and inexpensively. This method also avoids breakage of the end mill (ϕ = 0.4 mm) of the computerized numerical control (CNC) system when fabricating the narrow channels (width < 50 µm). The prominent surface roughness of the milled bottom-layer could be overcomed by pre-cured PDMS with size trade-off in design. Finally, emulsion formation successfully demonstrates the validity of the proposed fabrication protocol. This work represents an important step toward the use of a milling technique for PDMS-based microfabrication. |
| first_indexed | 2024-12-14T02:55:31Z |
| format | Article |
| id | doaj.art-2bcd8940fc5e46b28d5b628866c6b26a |
| institution | Directory Open Access Journal |
| issn | 2072-666X |
| language | English |
| last_indexed | 2024-12-14T02:55:31Z |
| publishDate | 2017-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj.art-2bcd8940fc5e46b28d5b628866c6b26a2022-12-21T23:19:38ZengMDPI AGMicromachines2072-666X2017-09-0181028710.3390/mi8100287mi8100287Milling Positive Master for Polydimethylsiloxane Microfluidic Devices: The Microfabrication and Roughness IssuesZhizhi Zhou0Dong Chen1Xiang Wang2Jiahuan Jiang3Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College of Chongqing University, Chongqing 400044, ChinaKey Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College of Chongqing University, Chongqing 400044, ChinaKey Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College of Chongqing University, Chongqing 400044, ChinaKey Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College of Chongqing University, Chongqing 400044, ChinaWe provide a facile and low-cost method (F-L) to fabricate a two-dimensional positive master using a milling technique for polydimethylsiloxane (PDMS)-based microchannel molding. This method comprises the following steps: (1) a positive microscale master of the geometry is milled on to an acrylic block; (2) pre-cured PDMS is used to mold the microscale positive master; (3) the PDMS plate is peeled off from the master and punctured with a blunt needle; and (4) the PDMS plate is O2 plasma bonded to a glass slide. Using this technique, we can fabricate microchannels with very simple protocols quickly and inexpensively. This method also avoids breakage of the end mill (ϕ = 0.4 mm) of the computerized numerical control (CNC) system when fabricating the narrow channels (width < 50 µm). The prominent surface roughness of the milled bottom-layer could be overcomed by pre-cured PDMS with size trade-off in design. Finally, emulsion formation successfully demonstrates the validity of the proposed fabrication protocol. This work represents an important step toward the use of a milling technique for PDMS-based microfabrication.https://www.mdpi.com/2072-666X/8/10/287microchannelmicrofluidicmillingacrylicemulsionspolydimethylsiloxane (PDMS) |
| spellingShingle | Zhizhi Zhou Dong Chen Xiang Wang Jiahuan Jiang Milling Positive Master for Polydimethylsiloxane Microfluidic Devices: The Microfabrication and Roughness Issues Micromachines microchannel microfluidic milling acrylic emulsions polydimethylsiloxane (PDMS) |
| title | Milling Positive Master for Polydimethylsiloxane Microfluidic Devices: The Microfabrication and Roughness Issues |
| title_full | Milling Positive Master for Polydimethylsiloxane Microfluidic Devices: The Microfabrication and Roughness Issues |
| title_fullStr | Milling Positive Master for Polydimethylsiloxane Microfluidic Devices: The Microfabrication and Roughness Issues |
| title_full_unstemmed | Milling Positive Master for Polydimethylsiloxane Microfluidic Devices: The Microfabrication and Roughness Issues |
| title_short | Milling Positive Master for Polydimethylsiloxane Microfluidic Devices: The Microfabrication and Roughness Issues |
| title_sort | milling positive master for polydimethylsiloxane microfluidic devices the microfabrication and roughness issues |
| topic | microchannel microfluidic milling acrylic emulsions polydimethylsiloxane (PDMS) |
| url | https://www.mdpi.com/2072-666X/8/10/287 |
| work_keys_str_mv | AT zhizhizhou millingpositivemasterforpolydimethylsiloxanemicrofluidicdevicesthemicrofabricationandroughnessissues AT dongchen millingpositivemasterforpolydimethylsiloxanemicrofluidicdevicesthemicrofabricationandroughnessissues AT xiangwang millingpositivemasterforpolydimethylsiloxanemicrofluidicdevicesthemicrofabricationandroughnessissues AT jiahuanjiang millingpositivemasterforpolydimethylsiloxanemicrofluidicdevicesthemicrofabricationandroughnessissues |