How to fail with paired VNS therapy
Vagus nerve stimulation (VNS) has gained enormous traction as a promising bioelectronic therapy. In particular, the delivery of VNS paired with training to promote neural changes has demonstrated clinical success for stroke recovery and found far-reaching application in other domains, from autism to...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Brain Stimulation |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1935861X23018818 |
| _version_ | 1827778506223779840 |
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| author | Seth A. Hays Robert L. Rennaker, II Michael P. Kilgard |
| author_facet | Seth A. Hays Robert L. Rennaker, II Michael P. Kilgard |
| author_sort | Seth A. Hays |
| collection | DOAJ |
| description | Vagus nerve stimulation (VNS) has gained enormous traction as a promising bioelectronic therapy. In particular, the delivery of VNS paired with training to promote neural changes has demonstrated clinical success for stroke recovery and found far-reaching application in other domains, from autism to psychiatric disorders to normal learning. The success of paired VNS has been extensively documented. Here, we consider a more unusual question: why does VNS have such broad utility, and perhaps more importantly, when does VNS not work? We present a discussion of the concepts that underlie VNS therapy and an anthology of studies that describe conditions in which these concepts are violated and VNS fails. We focus specifically on the mechanisms engaged by implanted VNS, and how the parameters of stimulation, stimulation method, pharmacological manipulations, accompanying comorbidities, and specifics of concurrent training interact with these mechanisms to impact the efficacy of VNS therapy. As paired VNS therapy is increasing translated to clinical implementation, a clear understanding of the conditions in which it does, and critically, does not work is fundamental to the success of this approach. |
| first_indexed | 2024-03-11T14:35:20Z |
| format | Article |
| id | doaj.art-2bce5d14cbea4c6d845cd8aecc2b390b |
| institution | Directory Open Access Journal |
| issn | 1935-861X |
| language | English |
| last_indexed | 2024-03-11T14:35:20Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Stimulation |
| spelling | doaj.art-2bce5d14cbea4c6d845cd8aecc2b390b2023-10-31T04:08:59ZengElsevierBrain Stimulation1935-861X2023-09-0116512521258How to fail with paired VNS therapySeth A. Hays0Robert L. Rennaker, II1Michael P. Kilgard2Texas Biomedical Device Center, The University of Texas at Dallas, Richardson, TX, USA; Erik Jonsson School of Engineering and Computer Science, The University of Texas at Dallas, Richardson, TX, USA; Corresponding author. Department of Bioengineering, Erik Jonsson School of Engineering and Computer Science, University of Texas at Dallas, 800 W Campbell Rd, Richardson, TX, 75080, USA.Texas Biomedical Device Center, The University of Texas at Dallas, Richardson, TX, USA; School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, TX, USATexas Biomedical Device Center, The University of Texas at Dallas, Richardson, TX, USA; School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, TX, USAVagus nerve stimulation (VNS) has gained enormous traction as a promising bioelectronic therapy. In particular, the delivery of VNS paired with training to promote neural changes has demonstrated clinical success for stroke recovery and found far-reaching application in other domains, from autism to psychiatric disorders to normal learning. The success of paired VNS has been extensively documented. Here, we consider a more unusual question: why does VNS have such broad utility, and perhaps more importantly, when does VNS not work? We present a discussion of the concepts that underlie VNS therapy and an anthology of studies that describe conditions in which these concepts are violated and VNS fails. We focus specifically on the mechanisms engaged by implanted VNS, and how the parameters of stimulation, stimulation method, pharmacological manipulations, accompanying comorbidities, and specifics of concurrent training interact with these mechanisms to impact the efficacy of VNS therapy. As paired VNS therapy is increasing translated to clinical implementation, a clear understanding of the conditions in which it does, and critically, does not work is fundamental to the success of this approach.http://www.sciencedirect.com/science/article/pii/S1935861X23018818Vagal nerve stimulationVagus nerve stimulationRehabilitationParametersRecovery |
| spellingShingle | Seth A. Hays Robert L. Rennaker, II Michael P. Kilgard How to fail with paired VNS therapy Brain Stimulation Vagal nerve stimulation Vagus nerve stimulation Rehabilitation Parameters Recovery |
| title | How to fail with paired VNS therapy |
| title_full | How to fail with paired VNS therapy |
| title_fullStr | How to fail with paired VNS therapy |
| title_full_unstemmed | How to fail with paired VNS therapy |
| title_short | How to fail with paired VNS therapy |
| title_sort | how to fail with paired vns therapy |
| topic | Vagal nerve stimulation Vagus nerve stimulation Rehabilitation Parameters Recovery |
| url | http://www.sciencedirect.com/science/article/pii/S1935861X23018818 |
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