Shared and differential fractional amplitude of low-frequency fluctuation patterns at rest in major depressive disorders with or without sleep disturbance
ObjectiveSleep disturbances (SD) are commonly found in patients with major depressive disorder (MDD). This study aims to explore the influence of SD symptoms on clinical characteristics in patients with MDD and to investigate the shared and distinct fractional amplitude of low-frequency fluctuation...
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Psychology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyg.2023.1153335/full |
| _version_ | 1797862495403114496 |
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| author | Nanxi Zheng Yangpan Ou Huabing Li Feng Liu Guojun Xie Ping Li Bing Lang Wenbin Guo |
| author_facet | Nanxi Zheng Yangpan Ou Huabing Li Feng Liu Guojun Xie Ping Li Bing Lang Wenbin Guo |
| author_sort | Nanxi Zheng |
| collection | DOAJ |
| description | ObjectiveSleep disturbances (SD) are commonly found in patients with major depressive disorder (MDD). This study aims to explore the influence of SD symptoms on clinical characteristics in patients with MDD and to investigate the shared and distinct fractional amplitude of low-frequency fluctuation (fALFF) patterns in these patients with or without SD symptoms.MethodsTwenty-four MDD patients with SD symptoms (Pa_s), 33 MDD patients without SD symptoms (Pa_ns) and 32 healthy controls (HCs) were included in this study. The fALFF and correlation analyses were applied to analyze the features of imaging and clinical data.ResultsPa_s showed more severe anxiety and depression than Pa_ns. Compared with Pa_ns, Pa_s exhibited increased fALFF value in the left precuneus. Patients shared abnormal fALFF in the frontal-occipital brain regions. There was a positive correlation between fALFF values of the left precuneus and sleep disturbance scores (r = 0.607, p = 0.0000056734) in all patients in addition to a negative correlation between fALFF values of the left MOG/cuneus and HAMD-17 total scores (r = −0.595, p = 0.002141) in Pa_s. The receiver operating characteristic (ROC) results of the fALFF could be used to discriminate Pa_s from Pa_ns with a specificity of 72.73% and a sensitivity of 70.83%.ConclusionPa_s displayed more serious anxiety and depression symptoms. Patients shared abnormal fALFF in the frontal-occipital brain regions, which may be a common characteristic for MDD. And increased fALFF value in the left precuneus might be a specific neuroimaging feature of MDD patients with SD symptoms. |
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| language | English |
| last_indexed | 2024-04-09T22:21:27Z |
| publishDate | 2023-03-01 |
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| series | Frontiers in Psychology |
| spelling | doaj.art-2bcfdafd984d4c039bf9223fcaa8c13e2023-03-22T14:58:33ZengFrontiers Media S.A.Frontiers in Psychology1664-10782023-03-011410.3389/fpsyg.2023.11533351153335Shared and differential fractional amplitude of low-frequency fluctuation patterns at rest in major depressive disorders with or without sleep disturbanceNanxi Zheng0Yangpan Ou1Huabing Li2Feng Liu3Guojun Xie4Ping Li5Bing Lang6Wenbin Guo7Department of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, ChinaDepartment of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, ChinaDepartment of Radiology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, ChinaDepartment of Radiology, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Psychiatry, The Third People's Hospital of Foshan, Foshan, Guangdong, ChinaDepartment of Psychiatry, Qiqihar Medical University, Qiqihar, Heilongjiang, ChinaDepartment of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, ChinaDepartment of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, ChinaObjectiveSleep disturbances (SD) are commonly found in patients with major depressive disorder (MDD). This study aims to explore the influence of SD symptoms on clinical characteristics in patients with MDD and to investigate the shared and distinct fractional amplitude of low-frequency fluctuation (fALFF) patterns in these patients with or without SD symptoms.MethodsTwenty-four MDD patients with SD symptoms (Pa_s), 33 MDD patients without SD symptoms (Pa_ns) and 32 healthy controls (HCs) were included in this study. The fALFF and correlation analyses were applied to analyze the features of imaging and clinical data.ResultsPa_s showed more severe anxiety and depression than Pa_ns. Compared with Pa_ns, Pa_s exhibited increased fALFF value in the left precuneus. Patients shared abnormal fALFF in the frontal-occipital brain regions. There was a positive correlation between fALFF values of the left precuneus and sleep disturbance scores (r = 0.607, p = 0.0000056734) in all patients in addition to a negative correlation between fALFF values of the left MOG/cuneus and HAMD-17 total scores (r = −0.595, p = 0.002141) in Pa_s. The receiver operating characteristic (ROC) results of the fALFF could be used to discriminate Pa_s from Pa_ns with a specificity of 72.73% and a sensitivity of 70.83%.ConclusionPa_s displayed more serious anxiety and depression symptoms. Patients shared abnormal fALFF in the frontal-occipital brain regions, which may be a common characteristic for MDD. And increased fALFF value in the left precuneus might be a specific neuroimaging feature of MDD patients with SD symptoms.https://www.frontiersin.org/articles/10.3389/fpsyg.2023.1153335/fullfractional amplitude of low-frequency fluctuationmajor depressive diorderssleep disturbanceMRIcorrelation |
| spellingShingle | Nanxi Zheng Yangpan Ou Huabing Li Feng Liu Guojun Xie Ping Li Bing Lang Wenbin Guo Shared and differential fractional amplitude of low-frequency fluctuation patterns at rest in major depressive disorders with or without sleep disturbance Frontiers in Psychology fractional amplitude of low-frequency fluctuation major depressive diorders sleep disturbance MRI correlation |
| title | Shared and differential fractional amplitude of low-frequency fluctuation patterns at rest in major depressive disorders with or without sleep disturbance |
| title_full | Shared and differential fractional amplitude of low-frequency fluctuation patterns at rest in major depressive disorders with or without sleep disturbance |
| title_fullStr | Shared and differential fractional amplitude of low-frequency fluctuation patterns at rest in major depressive disorders with or without sleep disturbance |
| title_full_unstemmed | Shared and differential fractional amplitude of low-frequency fluctuation patterns at rest in major depressive disorders with or without sleep disturbance |
| title_short | Shared and differential fractional amplitude of low-frequency fluctuation patterns at rest in major depressive disorders with or without sleep disturbance |
| title_sort | shared and differential fractional amplitude of low frequency fluctuation patterns at rest in major depressive disorders with or without sleep disturbance |
| topic | fractional amplitude of low-frequency fluctuation major depressive diorders sleep disturbance MRI correlation |
| url | https://www.frontiersin.org/articles/10.3389/fpsyg.2023.1153335/full |
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