Janus-kinase Inhibitors in Pathogenesis and Management of Chronic Urticaria: A Review of the Literature
Background: Chronic urticaria is a long-lasting condition, sometimes with serious comorbidities, severely affecting the quality of life, which makes the patients seek efficient therapies to achieve sustained remissions. The complex nature of urticaria greatly complicates the patients’ responses to a...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Mazandaran University of Medical Sciences
2023-04-01
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| Series: | Journal of Pediatrics Review |
| Subjects: | |
| Online Access: | http://jpr.mazums.ac.ir/article-1-475-en.pdf |
| _version_ | 1797801891071000576 |
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| author | Sepideh Darougar Seyed Karen Hashemitari Sara Montazeri Namin |
| author_facet | Sepideh Darougar Seyed Karen Hashemitari Sara Montazeri Namin |
| author_sort | Sepideh Darougar |
| collection | DOAJ |
| description | Background: Chronic urticaria is a long-lasting condition, sometimes with serious comorbidities, severely affecting the quality of life, which makes the patients seek efficient therapies to achieve sustained remissions. The complex nature of urticaria greatly complicates the patients’ responses to appropriate treatments.
Objectives: This review was conducted to focus on the Janus kinase (JAK) pathway, evaluate its role as a new biomarker, and discover the efficacy of its inhibitors as novel therapeutic agents in the treatment of refractory chronic urticaria.
Methods: Electronic databases of PubMed and SCOPUS were searched to find and evaluate all the reports describing “Janus kinase,” “JAK-STAT pathway,” “chronic urticaria,” “JAK inhibitors,” and “pruritus.” Because itching is the most annoying symptom of chronic urticaria and due to the scarcity of articles conducted on the use of JAK inhibitors in the treatment of this disease, we also reviewed quite a few articles performed on applying JAK inhibitors in the treatment of dermatologic disorders and also pruritus in atopic dermatitis.
Results: From the initially retrieved articles, only five were exclusively about the use of JAK inhibitors in the treatment of chronic urticaria.
Conclusions: Although JAK inhibitors are widely known as effective therapies in the treatment of some dermatological diseases, we found out that there are not currently sufficient eligible studies confirming the role of JAK inhibitors in the treatment of chronic urticaria. There is therefore a need for more studies regarding the efficacy and safety of these medications in the treatment of refractory chronic urticaria. |
| first_indexed | 2024-03-13T04:58:26Z |
| format | Article |
| id | doaj.art-2bd18de03d65417488a11fb136b4b949 |
| institution | Directory Open Access Journal |
| issn | 2322-4398 2322-4401 |
| language | English |
| last_indexed | 2024-03-13T04:58:26Z |
| publishDate | 2023-04-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Journal of Pediatrics Review |
| spelling | doaj.art-2bd18de03d65417488a11fb136b4b9492023-06-17T10:29:15ZengMazandaran University of Medical SciencesJournal of Pediatrics Review2322-43982322-44012023-04-01112153162Janus-kinase Inhibitors in Pathogenesis and Management of Chronic Urticaria: A Review of the LiteratureSepideh Darougar0Seyed Karen Hashemitari1Sara Montazeri Namin2 Department of Pediatrics, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran. Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Bu-Ali Hospital, Faculty of Medicine, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran. Background: Chronic urticaria is a long-lasting condition, sometimes with serious comorbidities, severely affecting the quality of life, which makes the patients seek efficient therapies to achieve sustained remissions. The complex nature of urticaria greatly complicates the patients’ responses to appropriate treatments. Objectives: This review was conducted to focus on the Janus kinase (JAK) pathway, evaluate its role as a new biomarker, and discover the efficacy of its inhibitors as novel therapeutic agents in the treatment of refractory chronic urticaria. Methods: Electronic databases of PubMed and SCOPUS were searched to find and evaluate all the reports describing “Janus kinase,” “JAK-STAT pathway,” “chronic urticaria,” “JAK inhibitors,” and “pruritus.” Because itching is the most annoying symptom of chronic urticaria and due to the scarcity of articles conducted on the use of JAK inhibitors in the treatment of this disease, we also reviewed quite a few articles performed on applying JAK inhibitors in the treatment of dermatologic disorders and also pruritus in atopic dermatitis. Results: From the initially retrieved articles, only five were exclusively about the use of JAK inhibitors in the treatment of chronic urticaria. Conclusions: Although JAK inhibitors are widely known as effective therapies in the treatment of some dermatological diseases, we found out that there are not currently sufficient eligible studies confirming the role of JAK inhibitors in the treatment of chronic urticaria. There is therefore a need for more studies regarding the efficacy and safety of these medications in the treatment of refractory chronic urticaria.http://jpr.mazums.ac.ir/article-1-475-en.pdfjak inhibitorschronic urticariajanus kinase pathwaypruritusjak-stat pathway |
| spellingShingle | Sepideh Darougar Seyed Karen Hashemitari Sara Montazeri Namin Janus-kinase Inhibitors in Pathogenesis and Management of Chronic Urticaria: A Review of the Literature Journal of Pediatrics Review jak inhibitors chronic urticaria janus kinase pathway pruritus jak-stat pathway |
| title | Janus-kinase Inhibitors in Pathogenesis and Management of Chronic Urticaria: A Review of the Literature |
| title_full | Janus-kinase Inhibitors in Pathogenesis and Management of Chronic Urticaria: A Review of the Literature |
| title_fullStr | Janus-kinase Inhibitors in Pathogenesis and Management of Chronic Urticaria: A Review of the Literature |
| title_full_unstemmed | Janus-kinase Inhibitors in Pathogenesis and Management of Chronic Urticaria: A Review of the Literature |
| title_short | Janus-kinase Inhibitors in Pathogenesis and Management of Chronic Urticaria: A Review of the Literature |
| title_sort | janus kinase inhibitors in pathogenesis and management of chronic urticaria a review of the literature |
| topic | jak inhibitors chronic urticaria janus kinase pathway pruritus jak-stat pathway |
| url | http://jpr.mazums.ac.ir/article-1-475-en.pdf |
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