Tiny miRNAs Play a Big Role in the Treatment of Breast Cancer Metastasis
Distant organ metastases accounts for the majority of breast cancer deaths. Given the prevalence of breast cancer in women, it is imperative to understand the underlying mechanisms of its metastatic progression and identify potential targets for therapy. Since their discovery in 1993, microRNAs (miR...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/13/2/337 |
| _version_ | 1797410077704978432 |
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| author | Andrea York Tiang Teo Xiaoqiang Xiang Minh TN Le Andrea Li-Ann Wong Qi Zeng Lingzhi Wang Boon-Cher Goh |
| author_facet | Andrea York Tiang Teo Xiaoqiang Xiang Minh TN Le Andrea Li-Ann Wong Qi Zeng Lingzhi Wang Boon-Cher Goh |
| author_sort | Andrea York Tiang Teo |
| collection | DOAJ |
| description | Distant organ metastases accounts for the majority of breast cancer deaths. Given the prevalence of breast cancer in women, it is imperative to understand the underlying mechanisms of its metastatic progression and identify potential targets for therapy. Since their discovery in 1993, microRNAs (miRNAs) have emerged as important regulators of tumour progression and metastasis in various cancers, playing either oncogenic or tumour suppressor roles. In the following review, we discuss the roles of miRNAs that potentiate four key areas of breast cancer metastasis—angiogenesis, epithelial-mesenchymal transition, the Warburg effect and the tumour microenvironment. We then evaluate the recent developments in miRNA-based therapies in breast cancer, which have shown substantial promise in controlling tumour progression and metastasis. Yet, certain challenges must be overcome before these strategies can be implemented in clinical trials. |
| first_indexed | 2024-03-09T04:24:37Z |
| format | Article |
| id | doaj.art-2bd2203d20874124ad94e2b0c664a4ba |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T04:24:37Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-2bd2203d20874124ad94e2b0c664a4ba2023-12-03T13:41:54ZengMDPI AGCancers2072-66942021-01-0113233710.3390/cancers13020337Tiny miRNAs Play a Big Role in the Treatment of Breast Cancer MetastasisAndrea York Tiang Teo0Xiaoqiang Xiang1Minh TN Le2Andrea Li-Ann Wong3Qi Zeng4Lingzhi Wang5Boon-Cher Goh6Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, SingaporeDepartment of Clinical Pharmacy, School of Pharmacy, Fudan University, Shanghai 20203, ChinaInstitute for Digital Medicine and Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, SingaporeDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, SingaporeInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore 138673, SingaporeCancer Science Institute of Singapore, National University of Singapore, Singapore 117599, SingaporeDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, SingaporeDistant organ metastases accounts for the majority of breast cancer deaths. Given the prevalence of breast cancer in women, it is imperative to understand the underlying mechanisms of its metastatic progression and identify potential targets for therapy. Since their discovery in 1993, microRNAs (miRNAs) have emerged as important regulators of tumour progression and metastasis in various cancers, playing either oncogenic or tumour suppressor roles. In the following review, we discuss the roles of miRNAs that potentiate four key areas of breast cancer metastasis—angiogenesis, epithelial-mesenchymal transition, the Warburg effect and the tumour microenvironment. We then evaluate the recent developments in miRNA-based therapies in breast cancer, which have shown substantial promise in controlling tumour progression and metastasis. Yet, certain challenges must be overcome before these strategies can be implemented in clinical trials.https://www.mdpi.com/2072-6694/13/2/337microRNAsbreast cancer metastasisbreast cancer therapymicroRNA-based therapy |
| spellingShingle | Andrea York Tiang Teo Xiaoqiang Xiang Minh TN Le Andrea Li-Ann Wong Qi Zeng Lingzhi Wang Boon-Cher Goh Tiny miRNAs Play a Big Role in the Treatment of Breast Cancer Metastasis Cancers microRNAs breast cancer metastasis breast cancer therapy microRNA-based therapy |
| title | Tiny miRNAs Play a Big Role in the Treatment of Breast Cancer Metastasis |
| title_full | Tiny miRNAs Play a Big Role in the Treatment of Breast Cancer Metastasis |
| title_fullStr | Tiny miRNAs Play a Big Role in the Treatment of Breast Cancer Metastasis |
| title_full_unstemmed | Tiny miRNAs Play a Big Role in the Treatment of Breast Cancer Metastasis |
| title_short | Tiny miRNAs Play a Big Role in the Treatment of Breast Cancer Metastasis |
| title_sort | tiny mirnas play a big role in the treatment of breast cancer metastasis |
| topic | microRNAs breast cancer metastasis breast cancer therapy microRNA-based therapy |
| url | https://www.mdpi.com/2072-6694/13/2/337 |
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