The role of the gut microbiota in the development of type 1 diabetes mellitus
At the beginning of the XXI century, with the advent of technical capabilities and new methods of genes sequencing, the attention of researchers to the study of the human metagenome has significantly increased. The interaction between changes in the qualitative and quantitative composition of the gu...
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| Format: | Article |
| Language: | English |
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Endocrinology Research Centre
2021-02-01
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| Series: | Сахарный диабет |
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| Online Access: | https://www.dia-endojournals.ru/jour/article/view/10326 |
| _version_ | 1797255126598025216 |
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| author | L. I. Ibragimova E. A. Kolpakova A. V. Dzagakhova L. V. Egshatyan E. V. Pokrovskaya O. S. Derevyanko T. V. Nikonova |
| author_facet | L. I. Ibragimova E. A. Kolpakova A. V. Dzagakhova L. V. Egshatyan E. V. Pokrovskaya O. S. Derevyanko T. V. Nikonova |
| author_sort | L. I. Ibragimova |
| collection | DOAJ |
| description | At the beginning of the XXI century, with the advent of technical capabilities and new methods of genes sequencing, the attention of researchers to the study of the human metagenome has significantly increased. The interaction between changes in the qualitative and quantitative composition of the gut microbiota (GM) and various diseases is being actively studied, a search for specific metabolites and genes of microorganisms that may be associated with the development, in particular, of immune-mediated diseases is underway. In recent years, a lot of new data have been published on the possible contribution of gut flora dysbiosis to the development of Type 1 Diabetes Mellitus (T1DM), while the first assumptions were put forward as far back as 1970s. The search for pathogenetic mechanisms of GM influence on the development and progression of T1DM is becoming an increasingly relevant objective, since in recent years the incidence of T1DM is rapidly increasing, which is a serious health problem throughout the world.This review discusses the current ideas about the role of GM in the immunopathogenesis of T1DM, new data on the near-term prospects in the study of the human macrogenome, current ideas about the role of GM in the immunopathogenesis of T1DM, and the possibility of applying this knowledge by the practitioner. |
| first_indexed | 2024-03-08T15:19:01Z |
| format | Article |
| id | doaj.art-2bd2887710424625b52597886d6e70fe |
| institution | Directory Open Access Journal |
| issn | 2072-0351 2072-0378 |
| language | English |
| last_indexed | 2024-04-24T22:00:54Z |
| publishDate | 2021-02-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj.art-2bd2887710424625b52597886d6e70fe2024-03-20T11:48:03ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782021-02-01241626910.14341/DM1032610861The role of the gut microbiota in the development of type 1 diabetes mellitusL. I. Ibragimova0E. A. Kolpakova1A. V. Dzagakhova2L. V. Egshatyan3E. V. Pokrovskaya4O. S. Derevyanko5T. V. Nikonova6Endocrinology Research CentreEndocrinology Research CentreEndocrinology Research CentreMoscow Clinical Research Center A.S. Loginova; A.I. Yevdokimov Moscow State University of Medicine and DentistryEndocrinology Research CentreLtd “DFC – West”Endocrinology Research CentreAt the beginning of the XXI century, with the advent of technical capabilities and new methods of genes sequencing, the attention of researchers to the study of the human metagenome has significantly increased. The interaction between changes in the qualitative and quantitative composition of the gut microbiota (GM) and various diseases is being actively studied, a search for specific metabolites and genes of microorganisms that may be associated with the development, in particular, of immune-mediated diseases is underway. In recent years, a lot of new data have been published on the possible contribution of gut flora dysbiosis to the development of Type 1 Diabetes Mellitus (T1DM), while the first assumptions were put forward as far back as 1970s. The search for pathogenetic mechanisms of GM influence on the development and progression of T1DM is becoming an increasingly relevant objective, since in recent years the incidence of T1DM is rapidly increasing, which is a serious health problem throughout the world.This review discusses the current ideas about the role of GM in the immunopathogenesis of T1DM, new data on the near-term prospects in the study of the human macrogenome, current ideas about the role of GM in the immunopathogenesis of T1DM, and the possibility of applying this knowledge by the practitioner.https://www.dia-endojournals.ru/jour/article/view/10326microbiotatype 1 diabetes mellitusgene sequencing |
| spellingShingle | L. I. Ibragimova E. A. Kolpakova A. V. Dzagakhova L. V. Egshatyan E. V. Pokrovskaya O. S. Derevyanko T. V. Nikonova The role of the gut microbiota in the development of type 1 diabetes mellitus Сахарный диабет microbiota type 1 diabetes mellitus gene sequencing |
| title | The role of the gut microbiota in the development of type 1 diabetes mellitus |
| title_full | The role of the gut microbiota in the development of type 1 diabetes mellitus |
| title_fullStr | The role of the gut microbiota in the development of type 1 diabetes mellitus |
| title_full_unstemmed | The role of the gut microbiota in the development of type 1 diabetes mellitus |
| title_short | The role of the gut microbiota in the development of type 1 diabetes mellitus |
| title_sort | role of the gut microbiota in the development of type 1 diabetes mellitus |
| topic | microbiota type 1 diabetes mellitus gene sequencing |
| url | https://www.dia-endojournals.ru/jour/article/view/10326 |
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