B cell receptor signaling and associated pathways in the pathogenesis of chronic lymphocytic leukemia

B cell receptor signaling and associated pathways in the pathogenesis of chronic lymphocytic leukemia

B cell antigen receptor (BCR) signaling is a key driver of growth and survival in both normal and malignant B cells. Several lines of evidence support an important pathogenic role of the BCR in chronic lymphocytic leukemia (CLL). The significant improvement of CLL patients’ survival with the use of...

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Bibliographic Details
Main Authors:	Vera K. Schmid, Elias Hobeika
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-02-01
Series:	Frontiers in Oncology
Subjects:	chronic lymphocytic leukemia (CLL) B cell receptor (BCR) signaling IGHV CD79a/b (Igα/Igβ) PI3K/AKT SYK
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2024.1339620/full

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