Serum triglyceride levels are associated with recurrence in patients with acute hypertriglyceridemic pancreatitis
AimTo analyze the clinical profile of patients with acute hypertriglyceridemic pancreatitis (HTGP) and explore risk factors for recurrence.MethodsA retrospective observational study was conducted in patients who experienced an attack of HTGP for the first time. Patients were followed until the recur...
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1079637/full |
| _version_ | 1827989891464560640 |
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| author | Langyi Guan Ling Ding Jianhua Wan Liang Xia Wenhua He Huifang Xiong Lingyu Luo Nonghua Lu Yin Zhu |
| author_facet | Langyi Guan Ling Ding Jianhua Wan Liang Xia Wenhua He Huifang Xiong Lingyu Luo Nonghua Lu Yin Zhu |
| author_sort | Langyi Guan |
| collection | DOAJ |
| description | AimTo analyze the clinical profile of patients with acute hypertriglyceridemic pancreatitis (HTGP) and explore risk factors for recurrence.MethodsA retrospective observational study was conducted in patients who experienced an attack of HTGP for the first time. Patients were followed until the recurrence of acute pancreatitis (AP) or 1 year. The detailed clinical profile was compared between patients with or without recurrence. Multivariate logistic regression analysis was conducted to explore independent risk factors for recurrence.ResultsA total of 108 HTGP patients were included in this study with 73.1% being male, and the median age being 37 (interquartile range, IQR, 30.3–44.8) years. Recurrence occurred in 70 patients (64.8%). Compared with the nonrecurrent group, serum triglyceride (TG) levels before discharge [4.1 (2.8,6.3) mmol/L vs. 2.9 (2.2,4.2) mmol/L; p = 0.002], at 1 month [3.7 (2.3,9.7) mmol/L vs. 2.0 (1.4,2.7) mmol/L; p = 0.001], at 6 months [6.1 (3.1,13.1) mmol/L vs. 2.5 (1.1,3.5) mmol/L; p = 0.003] and 12 months [9.6 (3.5,20.0) mmol/L vs. 2.7 (1.6,5.5) mmol/L; p = 0.001] after discharge were higher in the recurrent group. Poor control of TG levels (TG > 3.1 mmol/l) at the 1-month follow-up after discharge and a high Charlson’s Comorbidity Index score (≥ 2 points) increased the risk of recurrence of HTGP.ConclusionHigh TG levels during follow-up and Charlson’s Comorbidity Index score were independently associated with recurrence in patients with HTGP. |
| first_indexed | 2024-04-10T00:28:29Z |
| format | Article |
| id | doaj.art-2bd4d1cda4bc4c2b8fcac272032fda54 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-10T00:28:29Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-2bd4d1cda4bc4c2b8fcac272032fda542023-03-15T05:34:55ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-03-011010.3389/fmed.2023.10796371079637Serum triglyceride levels are associated with recurrence in patients with acute hypertriglyceridemic pancreatitisLangyi GuanLing DingJianhua WanLiang XiaWenhua HeHuifang XiongLingyu LuoNonghua LuYin ZhuAimTo analyze the clinical profile of patients with acute hypertriglyceridemic pancreatitis (HTGP) and explore risk factors for recurrence.MethodsA retrospective observational study was conducted in patients who experienced an attack of HTGP for the first time. Patients were followed until the recurrence of acute pancreatitis (AP) or 1 year. The detailed clinical profile was compared between patients with or without recurrence. Multivariate logistic regression analysis was conducted to explore independent risk factors for recurrence.ResultsA total of 108 HTGP patients were included in this study with 73.1% being male, and the median age being 37 (interquartile range, IQR, 30.3–44.8) years. Recurrence occurred in 70 patients (64.8%). Compared with the nonrecurrent group, serum triglyceride (TG) levels before discharge [4.1 (2.8,6.3) mmol/L vs. 2.9 (2.2,4.2) mmol/L; p = 0.002], at 1 month [3.7 (2.3,9.7) mmol/L vs. 2.0 (1.4,2.7) mmol/L; p = 0.001], at 6 months [6.1 (3.1,13.1) mmol/L vs. 2.5 (1.1,3.5) mmol/L; p = 0.003] and 12 months [9.6 (3.5,20.0) mmol/L vs. 2.7 (1.6,5.5) mmol/L; p = 0.001] after discharge were higher in the recurrent group. Poor control of TG levels (TG > 3.1 mmol/l) at the 1-month follow-up after discharge and a high Charlson’s Comorbidity Index score (≥ 2 points) increased the risk of recurrence of HTGP.ConclusionHigh TG levels during follow-up and Charlson’s Comorbidity Index score were independently associated with recurrence in patients with HTGP.https://www.frontiersin.org/articles/10.3389/fmed.2023.1079637/fullacute pancreatitisrecurrencerisk factorhypertriglyceridemiafollow-up |
| spellingShingle | Langyi Guan Ling Ding Jianhua Wan Liang Xia Wenhua He Huifang Xiong Lingyu Luo Nonghua Lu Yin Zhu Serum triglyceride levels are associated with recurrence in patients with acute hypertriglyceridemic pancreatitis Frontiers in Medicine acute pancreatitis recurrence risk factor hypertriglyceridemia follow-up |
| title | Serum triglyceride levels are associated with recurrence in patients with acute hypertriglyceridemic pancreatitis |
| title_full | Serum triglyceride levels are associated with recurrence in patients with acute hypertriglyceridemic pancreatitis |
| title_fullStr | Serum triglyceride levels are associated with recurrence in patients with acute hypertriglyceridemic pancreatitis |
| title_full_unstemmed | Serum triglyceride levels are associated with recurrence in patients with acute hypertriglyceridemic pancreatitis |
| title_short | Serum triglyceride levels are associated with recurrence in patients with acute hypertriglyceridemic pancreatitis |
| title_sort | serum triglyceride levels are associated with recurrence in patients with acute hypertriglyceridemic pancreatitis |
| topic | acute pancreatitis recurrence risk factor hypertriglyceridemia follow-up |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1079637/full |
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