FAK Regulates VEGFR2 Expression and Promotes Angiogenesis in Triple-Negative Breast Cancer

FAK Regulates VEGFR2 Expression and Promotes Angiogenesis in Triple-Negative Breast Cancer

Triple-negative breast cancer (TNBC) remains a significant clinical challenge because of its high vascularity and metastatic and recurrent rates. Tumor angiogenesis is considered an important mediator in the regulation of tumor cell survival and metastasis in TNBC. Angiogenesis is induced by the bin...

Full description

Bibliographic Details
Main Authors:	Jun-Ping Shiau, Cheng-Che Wu, Shu-Jyuan Chang, Mei-Ren Pan, Wangta Liu, Fu Ou-Yang, Fang-Ming Chen, Ming-Feng Hou, Shen-Liang Shih, Chi-Wen Luo
Format:	Article
Language:	English
Published:	MDPI AG 2021-11-01
Series:	Biomedicines
Subjects:	focal adhesion kinase (FAK) vascular endothelial growth factor 2 (VEGFR2) triple-negative breast cancer (TNBC) angiogenesis
Online Access:	https://www.mdpi.com/2227-9059/9/12/1789

Similar Items

Structure-Based Virtual Screening, Synthesis and Biological Evaluation of Potential FAK-FAT Domain Inhibitors for Treatment of Metastatic Cancer
by: Sahar B. Kandil, et al.
Published: (2020-07-01)

FAK family kinases: The Yin and Yang of cancer cell invasiveness
by: Alessandro Genna, et al.
Published: (2018-07-01)

Signal Transduction Mechanisms of Focal Adhesions: Src and FAK-Mediated Cell Response
by: Kazuo Katoh
Published: (2024-11-01)

Discovery of dual kinase inhibitors targeting VEGFR2 and FAK: structure-based pharmacophore modeling, virtual screening, and molecular docking studies
by: Marwa A. Fouad, et al.
Published: (2024-02-01)

FAK-Dependent Cell Motility and Cell Elongation
by: Kazuo Katoh
Published: (2020-01-01)

Atovaquone Suppresses the Growth of Metastatic Triple-Negative Breast Tumors in Lungs and Brain by Inhibiting Integrin/FAK Signaling Axis
by: Nehal Gupta, et al.
Published: (2021-05-01)

LncRNA FAISL Inhibits Calpain 2‐Mediated Proteolysis of FAK to Promote Progression and Metastasis of Triple Negative Breast Cancer
by: Yunmei Zhang, et al.
Published: (2024-11-01)

Simultaneous inhibition of FAK and ROS1 synergistically repressed triple-negative breast cancer by upregulating p53 signalling
by: Ximin Tan, et al.
Published: (2024-01-01)

S1PR1 and VEGFR2 – a synergy that promotes tumor angiogenesis?
by: Vijay Avin Balaji Ragunathrao, et al.
Published: (2020-07-01)

A single-arm phase II clinical trial of anlotinib combined with chemotherapy for the treatment of metastatic triple-negative breast cancer
by: Jia-Yi Huang, et al.
Published: (2023-04-01)

Electrical Stimulation Causes Activation of c-Src and Focal Adhesion Kinase in Fibroblasts
by: Kazuo Katoh
Published: (2023-03-01)

Association of VEGFR1, VEGFR2 and VEGFR3 polymorphisms with esophageal cancer risk: a case–control study
by: Sukhpreet Kaur Walia, et al.
Published: (2024-08-01)

The VEGFs/VEGFRs system in Alzheimer’s and Parkinson’s diseases: Pathophysiological roles and therapeutic implications
by: Claudia Ceci, et al.
Published: (2024-03-01)

Elements of the Endomucin Extracellular Domain Essential for VEGF-Induced VEGFR2 Activity
by: Zhengping Hu, et al.
Published: (2020-06-01)

IGF-1/IGF-1R/FAK/YAP Transduction Signaling Prompts Growth Effects in Triple-Negative Breast Cancer (TNBC) Cells
by: Damiano Cosimo Rigiracciolo, et al.
Published: (2020-04-01)

Targeting FAK/PYK2 with SJP1602 for Anti-Tumor Activity in Triple-Negative Breast Cancer
by: Myeongjin Jeon, et al.
Published: (2023-08-01)

Recycling machinery of integrin coupled with focal adhesion turnover via RAB11-UNC13D-FAK axis for migration of pancreatic cancer cells
by: Van-Thanh Duong, et al.
Published: (2024-08-01)

VEGF-A, sVEGFR-1, and sVEGFR-2 in BCR-ABL negative myeloproliferative neoplasms
by: Grażyna Gadomska, et al.
Published: (2017-01-01)

FAK Inhibition Attenuates Corneal Fibroblast Differentiation In Vitro
by: Vincent Yeung, et al.
Published: (2021-11-01)

Biomechanical stimulation promotes blood vessel growth despite VEGFR-2 inhibition
by: Bronte Miller Johnson, et al.
Published: (2023-12-01)

A Recombinant Lentiviral Vegfr2-Silencing Vector Attenuates Roxarsone-Promoted Growth of Rat Vascular Endothelial Cells and Angiogenesis in Matrigel Plug and B16F10 Xenograft Models
by: Xin Chen, et al.
Published: (2024-09-01)

Selenium–Chondroitin Sulfate Nanoparticles Inhibit Angiogenesis by Regulating the VEGFR2-Mediated PI3K/Akt Pathway
by: Xia Zheng, et al.
Published: (2025-01-01)

VEGFA, VEGFR1, VEGFR2 serum and cerebrospinal fluid concentration in patients with acute leukemia
by: E. I. Zakharko, et al.
Published: (2024-04-01)

Modified Benzoxazole-Based VEGFR-2 Inhibitors and Apoptosis Inducers: Design, Synthesis, and Anti-Proliferative Evaluation
by: Alaa Elwan, et al.
Published: (2022-08-01)

Endosome-to-Plasma Membrane Recycling of VEGFR2 Receptor Tyrosine Kinase Regulates Endothelial Function and Blood Vessel Formation
by: Helen M. Jopling, et al.
Published: (2014-04-01)

LOX upregulates FAK phosphorylation to promote metastasis in osteosarcoma
by: Xiang Chen, et al.
Published: (2023-01-01)

ERK5 suppression overcomes FAK inhibitor resistance in mutant KRAS-driven non-small cell lung cancer
by: Chiara Pozzato, et al.
Published: (2024-09-01)

A luciferase fragment complementation assay to detect focal adhesion kinase (FAK) signaling events
by: Jason A. Estep, et al.
Published: (2023-04-01)

PF573,228 inhibits vascular tumor cell growth, migration as well as angiogenesis, induces apoptosis and abrogates PRAS40 and S6RP phosphorylation
by: Mabeta Peace
Published: (2016-09-01)

Quercetin Inhibits Colorectal Cancer Cells Induced-Angiogenesis in Both Colorectal Cancer Cell and Endothelial Cell through Downregulation of VEGF-A/VEGFR2
by: Tamonwan Uttarawichien, et al.
Published: (2021-05-01)

Integrins linked kinase and focal adhesion kinase as the key signaling mediators of vascular mimicry in metastatic breast tumor cells
by: Mohammad Kamalabadi-Farahani, et al.
Published: (2024-10-01)

Triple-negative mouse breast cancer initiating cells show high expression of beta1 integrin and increased malignant features
by: Fu Jing, et al.
Published: (2023-03-01)

A Tympanic Piezo‐Bioreactor Modulates Ion Channel‐Associated Mechanosignaling to Stabilize Phenotype and Promote Tenogenesis in Human Tendon‐Derived Cells.
by: Marc A. Fernandez‐Yague, et al.
Published: (2024-12-01)

Focal Adhesion’s Role in Cardiomyocytes Function: From Cardiomyogenesis to Mechanotransduction
by: Simona Casarella, et al.
Published: (2024-04-01)

FAK Family Kinases: A Potential Therapeutic Target for Atherosclerosis
by: Guan X, et al.
Published: (2024-08-01)

Recent advances of anti-angiogenic inhibitors targeting VEGF/VEGFR axis
by: Lei Wang, et al.
Published: (2024-01-01)

Extracellular Vesicles from Human Umbilical Cord-Derived MSCs Affect Vessel Formation In Vitro and Promote VEGFR2-Mediated Cell Survival
by: Ana Muñiz-García, et al.
Published: (2022-11-01)

Synthesis, biological evaluation, and in silico study of novel coumarin-quinazoline analogs as potential Anti-Angiogenesis agents
by: Zahra Emamgholipour, et al.
Published: (2024-10-01)

LRP-1 Matricellular Receptor Involvement in Triple Negative Breast Cancer Tumor Angiogenesis
by: Océane Campion, et al.
Published: (2021-10-01)

Dexmedetomidine Protects the Brain: Exploring the α2AR/FAK Pathway in Post-Stroke Intestinal Barrier Repair
by: Xinting Zhou, et al.
Published: (2025-02-01)