A perspective on the role of physiological stresses in cancer, diabetes and cognitive disease as environmental diseases
With rapid industrialization, urbanization, and climate change, the impact of environmental factors on human health is becoming increasingly evident and understanding the complex mechanisms involved is vital from a healthcare perspective. Nevertheless, the relationship between physiological stress r...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2023.1274221/full |
| _version_ | 1797560903929954304 |
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| author | Maranda Esterhuizen Chang-Beom Park Young Jun Kim Tae-Young Kim Hakwon Yoon Frederic Andres Rosalia Rodriguez-Rodriguez Rosalia Rodriguez-Rodriguez Shihori Tanabe |
| author_facet | Maranda Esterhuizen Chang-Beom Park Young Jun Kim Tae-Young Kim Hakwon Yoon Frederic Andres Rosalia Rodriguez-Rodriguez Rosalia Rodriguez-Rodriguez Shihori Tanabe |
| author_sort | Maranda Esterhuizen |
| collection | DOAJ |
| description | With rapid industrialization, urbanization, and climate change, the impact of environmental factors on human health is becoming increasingly evident and understanding the complex mechanisms involved is vital from a healthcare perspective. Nevertheless, the relationship between physiological stress resulting from environmental stressors and environmental disease is complex and not well understood. Chronic exposure to environmental stressors, such as air and water contaminants, pesticides, and toxic metals, has been recognized as a potent elicitor of physiological responses ranging from systemic inflammation to immune system dysregulation causing or progressing environmental diseases. Conversely, physiological stress can exacerbate susceptibility to environmental diseases. Stress-induced alterations in immune function and hormonal balance may impair the ability to detoxify harmful substances and combat pathogens. Additionally, prolonged stress can impact lifestyle choices, leading to harmful behaviors. Understanding the link between physiological stress and environmental disease requires a systematic, multidisciplinary approach. Addressing this complex relationship necessitates the establishment of a global research network. This perspective discusses the intricate interplay between physiological stress and environmental disease, focusing on common environmental diseases, cancer, diabetes, and cognitive degeneration. Furthermore, we highlight the intricate and reciprocal nature of the connection between physiological stress and these environmental diseases giving a perspective on the current state of knowledge as well as identifying where further information is necessary. Recognizing the role of physiological stress in environmental health outcomes will aid in the development of comprehensive strategies to safeguard public health and promote ecological balance. |
| first_indexed | 2024-03-10T18:06:49Z |
| format | Article |
| id | doaj.art-2bd676b2c3c142638066b241c5433fec |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-03-10T18:06:49Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-2bd676b2c3c142638066b241c5433fec2023-11-20T08:26:51ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2023-11-011010.3389/fmolb.2023.12742211274221A perspective on the role of physiological stresses in cancer, diabetes and cognitive disease as environmental diseasesMaranda Esterhuizen0Chang-Beom Park1Young Jun Kim2Tae-Young Kim3Hakwon Yoon4Frederic Andres5Rosalia Rodriguez-Rodriguez6Rosalia Rodriguez-Rodriguez7Shihori Tanabe8Ecosystems and Environment Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Lahti, FinlandEnvironmental Exposure and Toxicology Research Center, Korea Institute Toxicology (KIT), Jinju, Republic of KoreaKorean Institute of Science and Technology Europe (KIST Europe), Saarbrücken, GermanySchool of Earth Sciences and Environmental Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju, Republic of KoreaEnvironmental Exposure and Toxicology Research Center, Korea Institute Toxicology (KIT), Jinju, Republic of KoreaDigital Content and Media Sciences Research Division, National Institute of Informatics, Tokyo, JapanDepartment of Basic Sciences, Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya (UIC Barcelona), Barcelona, SpainCentro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, SpainDivision of Risk Assessment, Center for Biological Safety and Research, National Institute of Health Sciences, Kawasaki, JapanWith rapid industrialization, urbanization, and climate change, the impact of environmental factors on human health is becoming increasingly evident and understanding the complex mechanisms involved is vital from a healthcare perspective. Nevertheless, the relationship between physiological stress resulting from environmental stressors and environmental disease is complex and not well understood. Chronic exposure to environmental stressors, such as air and water contaminants, pesticides, and toxic metals, has been recognized as a potent elicitor of physiological responses ranging from systemic inflammation to immune system dysregulation causing or progressing environmental diseases. Conversely, physiological stress can exacerbate susceptibility to environmental diseases. Stress-induced alterations in immune function and hormonal balance may impair the ability to detoxify harmful substances and combat pathogens. Additionally, prolonged stress can impact lifestyle choices, leading to harmful behaviors. Understanding the link between physiological stress and environmental disease requires a systematic, multidisciplinary approach. Addressing this complex relationship necessitates the establishment of a global research network. This perspective discusses the intricate interplay between physiological stress and environmental disease, focusing on common environmental diseases, cancer, diabetes, and cognitive degeneration. Furthermore, we highlight the intricate and reciprocal nature of the connection between physiological stress and these environmental diseases giving a perspective on the current state of knowledge as well as identifying where further information is necessary. Recognizing the role of physiological stress in environmental health outcomes will aid in the development of comprehensive strategies to safeguard public health and promote ecological balance.https://www.frontiersin.org/articles/10.3389/fmolb.2023.1274221/fullenvironmental stressorsreactive oxygen speciesenvironmental diseasehuman healthcancercognitive function |
| spellingShingle | Maranda Esterhuizen Chang-Beom Park Young Jun Kim Tae-Young Kim Hakwon Yoon Frederic Andres Rosalia Rodriguez-Rodriguez Rosalia Rodriguez-Rodriguez Shihori Tanabe A perspective on the role of physiological stresses in cancer, diabetes and cognitive disease as environmental diseases Frontiers in Molecular Biosciences environmental stressors reactive oxygen species environmental disease human health cancer cognitive function |
| title | A perspective on the role of physiological stresses in cancer, diabetes and cognitive disease as environmental diseases |
| title_full | A perspective on the role of physiological stresses in cancer, diabetes and cognitive disease as environmental diseases |
| title_fullStr | A perspective on the role of physiological stresses in cancer, diabetes and cognitive disease as environmental diseases |
| title_full_unstemmed | A perspective on the role of physiological stresses in cancer, diabetes and cognitive disease as environmental diseases |
| title_short | A perspective on the role of physiological stresses in cancer, diabetes and cognitive disease as environmental diseases |
| title_sort | perspective on the role of physiological stresses in cancer diabetes and cognitive disease as environmental diseases |
| topic | environmental stressors reactive oxygen species environmental disease human health cancer cognitive function |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2023.1274221/full |
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