The enhancement of activity rescues the establishment of Mecp2 null neuronal phenotypes

The enhancement of activity rescues the establishment of Mecp2 null neuronal phenotypes

Abstract MECP2 mutations cause Rett syndrome (RTT), a severe and progressive neurodevelopmental disorder mainly affecting females. Although RTT patients exhibit delayed onset of symptoms, several evidences demonstrate that MeCP2 deficiency alters early development of the brain. Indeed, during early...

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Main Authors: Linda Scaramuzza, Giuseppina De Rocco, Genni Desiato, Clementina Cobolli Gigli, Martina Chiacchiaretta, Filippo Mirabella, Davide Pozzi, Marco De Simone, Paola Conforti, Massimiliano Pagani, Fabio Benfenati, Fabrizia Cesca, Francesco Bedogni, Nicoletta Landsberger
Format: Article
Language:English
Published: Springer Nature 2021-04-01
Series:EMBO Molecular Medicine
Subjects:
Ampakine
Mecp2
neuronal activity
neuronal maturation
Rett syndrome
Online Access:https://doi.org/10.15252/emmm.202012433

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