THALASSEMIA AND VENOUS THROMBOEMBOLISM
Although the life expectancy of thalassemia patients has markedly improved over the last few decades, patients still suffer from many complications of this congenital disease. The presence of a high incidence of thromboembolic events, mainly in thalassemia intermedia, has led to the identification o...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Mattioli1885
2011-05-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
| Online Access: | http://www.mjhid.org/index.php/mjhid/article/view/281 |
| _version_ | 1819001589665366016 |
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| author | Julien Succar Khaled M. Musallam Ali T Taher |
| author_facet | Julien Succar Khaled M. Musallam Ali T Taher |
| author_sort | Julien Succar |
| collection | DOAJ |
| description | Although the life expectancy of thalassemia patients has markedly improved over the last few decades, patients still suffer from many complications of this congenital disease. The presence of a high incidence of thromboembolic events, mainly in thalassemia intermedia, has led to the identification of a hypercoagulable state in these patients. In this review, the molecular and cellular mechanisms leading to hypercoagulability in thalassemia are highlighted, with a special focus on thalassemia intermedia being the group with the highest incidence of thrombotic events as compared to other types of thalassemia. Clinical experience and available clues on optimal management are also discussed |
| first_indexed | 2024-12-20T22:51:37Z |
| format | Article |
| id | doaj.art-2bdac75a5fba4f8eb26616f0e37d7ec0 |
| institution | Directory Open Access Journal |
| issn | 2035-3006 |
| language | English |
| last_indexed | 2024-12-20T22:51:37Z |
| publishDate | 2011-05-01 |
| publisher | Mattioli1885 |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj.art-2bdac75a5fba4f8eb26616f0e37d7ec02022-12-21T19:24:13ZengMattioli1885Mediterranean Journal of Hematology and Infectious Diseases2035-30062011-05-0131e2011025e201102510.4084/mjhid.2011.025173THALASSEMIA AND VENOUS THROMBOEMBOLISMJulien SuccarKhaled M. MusallamAli T TaherAlthough the life expectancy of thalassemia patients has markedly improved over the last few decades, patients still suffer from many complications of this congenital disease. The presence of a high incidence of thromboembolic events, mainly in thalassemia intermedia, has led to the identification of a hypercoagulable state in these patients. In this review, the molecular and cellular mechanisms leading to hypercoagulability in thalassemia are highlighted, with a special focus on thalassemia intermedia being the group with the highest incidence of thrombotic events as compared to other types of thalassemia. Clinical experience and available clues on optimal management are also discussedhttp://www.mjhid.org/index.php/mjhid/article/view/281 |
| spellingShingle | Julien Succar Khaled M. Musallam Ali T Taher THALASSEMIA AND VENOUS THROMBOEMBOLISM Mediterranean Journal of Hematology and Infectious Diseases |
| title | THALASSEMIA AND VENOUS THROMBOEMBOLISM |
| title_full | THALASSEMIA AND VENOUS THROMBOEMBOLISM |
| title_fullStr | THALASSEMIA AND VENOUS THROMBOEMBOLISM |
| title_full_unstemmed | THALASSEMIA AND VENOUS THROMBOEMBOLISM |
| title_short | THALASSEMIA AND VENOUS THROMBOEMBOLISM |
| title_sort | thalassemia and venous thromboembolism |
| url | http://www.mjhid.org/index.php/mjhid/article/view/281 |
| work_keys_str_mv | AT juliensuccar thalassemiaandvenousthromboembolism AT khaledmmusallam thalassemiaandvenousthromboembolism AT alittaher thalassemiaandvenousthromboembolism |