Effects of biological sex mismatch on neural progenitor cell transplantation for spinal cord injury in mice
In this study, Pitonak et al. report that transplantation of neural progenitor cells derived from male donors trigger an immune rejection response following transplantation into sites of spinal cord injury in female mice.
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-09-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-33134-x |
| _version_ | 1818021240705646592 |
|---|---|
| author | Michael Pitonak Miriam Aceves Prakruthi Amar Kumar Gabrielle Dampf Peyton Green Ashley Tucker Valerie Dietz Diego Miranda Sunjay Letchuman Michelle M. Jonika David Bautista Heath Blackmon Jennifer N. Dulin |
| author_facet | Michael Pitonak Miriam Aceves Prakruthi Amar Kumar Gabrielle Dampf Peyton Green Ashley Tucker Valerie Dietz Diego Miranda Sunjay Letchuman Michelle M. Jonika David Bautista Heath Blackmon Jennifer N. Dulin |
| author_sort | Michael Pitonak |
| collection | DOAJ |
| description | In this study, Pitonak et al. report that transplantation of neural progenitor cells derived from male donors trigger an immune rejection response following transplantation into sites of spinal cord injury in female mice. |
| first_indexed | 2024-04-14T08:16:17Z |
| format | Article |
| id | doaj.art-2bdd3506386045a7876258c68ba61e2f |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-14T08:16:17Z |
| publishDate | 2022-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-2bdd3506386045a7876258c68ba61e2f2022-12-22T02:04:24ZengNature PortfolioNature Communications2041-17232022-09-0113111210.1038/s41467-022-33134-xEffects of biological sex mismatch on neural progenitor cell transplantation for spinal cord injury in miceMichael Pitonak0Miriam Aceves1Prakruthi Amar Kumar2Gabrielle Dampf3Peyton Green4Ashley Tucker5Valerie Dietz6Diego Miranda7Sunjay Letchuman8Michelle M. Jonika9David Bautista10Heath Blackmon11Jennifer N. Dulin12Department of Biology, Texas A&M UniversityDepartment of Biology, Texas A&M UniversityDepartment of Biology, Texas A&M UniversityDepartment of Biology, Texas A&M UniversityGanado High SchoolDepartment of Biology, Texas A&M UniversityDepartment of Biology, Texas A&M UniversityDepartment of Biology, Texas A&M UniversityDepartment of Biology, Texas A&M UniversityDepartment of Biology, Texas A&M UniversityDepartment of Biology, Texas A&M UniversityDepartment of Biology, Texas A&M UniversityDepartment of Biology, Texas A&M UniversityIn this study, Pitonak et al. report that transplantation of neural progenitor cells derived from male donors trigger an immune rejection response following transplantation into sites of spinal cord injury in female mice.https://doi.org/10.1038/s41467-022-33134-x |
| spellingShingle | Michael Pitonak Miriam Aceves Prakruthi Amar Kumar Gabrielle Dampf Peyton Green Ashley Tucker Valerie Dietz Diego Miranda Sunjay Letchuman Michelle M. Jonika David Bautista Heath Blackmon Jennifer N. Dulin Effects of biological sex mismatch on neural progenitor cell transplantation for spinal cord injury in mice Nature Communications |
| title | Effects of biological sex mismatch on neural progenitor cell transplantation for spinal cord injury in mice |
| title_full | Effects of biological sex mismatch on neural progenitor cell transplantation for spinal cord injury in mice |
| title_fullStr | Effects of biological sex mismatch on neural progenitor cell transplantation for spinal cord injury in mice |
| title_full_unstemmed | Effects of biological sex mismatch on neural progenitor cell transplantation for spinal cord injury in mice |
| title_short | Effects of biological sex mismatch on neural progenitor cell transplantation for spinal cord injury in mice |
| title_sort | effects of biological sex mismatch on neural progenitor cell transplantation for spinal cord injury in mice |
| url | https://doi.org/10.1038/s41467-022-33134-x |
| work_keys_str_mv | AT michaelpitonak effectsofbiologicalsexmismatchonneuralprogenitorcelltransplantationforspinalcordinjuryinmice AT miriamaceves effectsofbiologicalsexmismatchonneuralprogenitorcelltransplantationforspinalcordinjuryinmice AT prakruthiamarkumar effectsofbiologicalsexmismatchonneuralprogenitorcelltransplantationforspinalcordinjuryinmice AT gabrielledampf effectsofbiologicalsexmismatchonneuralprogenitorcelltransplantationforspinalcordinjuryinmice AT peytongreen effectsofbiologicalsexmismatchonneuralprogenitorcelltransplantationforspinalcordinjuryinmice AT ashleytucker effectsofbiologicalsexmismatchonneuralprogenitorcelltransplantationforspinalcordinjuryinmice AT valeriedietz effectsofbiologicalsexmismatchonneuralprogenitorcelltransplantationforspinalcordinjuryinmice AT diegomiranda effectsofbiologicalsexmismatchonneuralprogenitorcelltransplantationforspinalcordinjuryinmice AT sunjayletchuman effectsofbiologicalsexmismatchonneuralprogenitorcelltransplantationforspinalcordinjuryinmice AT michellemjonika effectsofbiologicalsexmismatchonneuralprogenitorcelltransplantationforspinalcordinjuryinmice AT davidbautista effectsofbiologicalsexmismatchonneuralprogenitorcelltransplantationforspinalcordinjuryinmice AT heathblackmon effectsofbiologicalsexmismatchonneuralprogenitorcelltransplantationforspinalcordinjuryinmice AT jenniferndulin effectsofbiologicalsexmismatchonneuralprogenitorcelltransplantationforspinalcordinjuryinmice |