Pathogenesis of Salmonella-induced enteritis
Infections with Salmonella serotypes are a major cause of food-borne diseases worldwide. Animal models other than the mouse have been employed for the study of nontyphoidal Salmonella infections because the murine model is not suitable for the study of Salmonella-induced diarrhea. The microbe has de...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
2003-01-01
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| Series: | Brazilian Journal of Medical and Biological Research |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000100002 |
| _version_ | 1818204746701340672 |
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| author | R.L. Santos R.M. Tsolis A.J. Bäumler L.G. Adams |
| author_facet | R.L. Santos R.M. Tsolis A.J. Bäumler L.G. Adams |
| author_sort | R.L. Santos |
| collection | DOAJ |
| description | Infections with Salmonella serotypes are a major cause of food-borne diseases worldwide. Animal models other than the mouse have been employed for the study of nontyphoidal Salmonella infections because the murine model is not suitable for the study of Salmonella-induced diarrhea. The microbe has developed mechanisms to exploit the host cell machinery to its own purpose. Bacterial proteins delivered directly into the host cell cytosol cause cytoskeletal changes and interfere with host cell signaling pathways, which ultimately enhance disease manifestation. Recently, marked advances have been made in our understanding of the molecular interactions between Salmonella serotypes and their hosts. Here, we discuss the molecular basis of the pathogenesis of Salmonella-induced enteritis. |
| first_indexed | 2024-12-12T03:46:08Z |
| format | Article |
| id | doaj.art-2bdd637576eb4c8099e0f763ead2d40f |
| institution | Directory Open Access Journal |
| issn | 0100-879X 1414-431X |
| language | English |
| last_indexed | 2024-12-12T03:46:08Z |
| publishDate | 2003-01-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-2bdd637576eb4c8099e0f763ead2d40f2022-12-22T00:39:33ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X1414-431X2003-01-01361031210.1590/S0100-879X2003000100002Pathogenesis of Salmonella-induced enteritisR.L. SantosR.M. TsolisA.J. BäumlerL.G. AdamsInfections with Salmonella serotypes are a major cause of food-borne diseases worldwide. Animal models other than the mouse have been employed for the study of nontyphoidal Salmonella infections because the murine model is not suitable for the study of Salmonella-induced diarrhea. The microbe has developed mechanisms to exploit the host cell machinery to its own purpose. Bacterial proteins delivered directly into the host cell cytosol cause cytoskeletal changes and interfere with host cell signaling pathways, which ultimately enhance disease manifestation. Recently, marked advances have been made in our understanding of the molecular interactions between Salmonella serotypes and their hosts. Here, we discuss the molecular basis of the pathogenesis of Salmonella-induced enteritis.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000100002Salmonella typhimuriumEnteritisDiarrheaSalmonellosis |
| spellingShingle | R.L. Santos R.M. Tsolis A.J. Bäumler L.G. Adams Pathogenesis of Salmonella-induced enteritis Brazilian Journal of Medical and Biological Research Salmonella typhimurium Enteritis Diarrhea Salmonellosis |
| title | Pathogenesis of Salmonella-induced enteritis |
| title_full | Pathogenesis of Salmonella-induced enteritis |
| title_fullStr | Pathogenesis of Salmonella-induced enteritis |
| title_full_unstemmed | Pathogenesis of Salmonella-induced enteritis |
| title_short | Pathogenesis of Salmonella-induced enteritis |
| title_sort | pathogenesis of salmonella induced enteritis |
| topic | Salmonella typhimurium Enteritis Diarrhea Salmonellosis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000100002 |
| work_keys_str_mv | AT rlsantos pathogenesisofsalmonellainducedenteritis AT rmtsolis pathogenesisofsalmonellainducedenteritis AT ajbaumler pathogenesisofsalmonellainducedenteritis AT lgadams pathogenesisofsalmonellainducedenteritis |