High-Sensitivity Troponin I and Cardiovascular Events in Stable Coronary Artery Disease: Insights from a Longitudinal Outpatient Study
Numerous studies have been published suggesting that troponin levels are related to adverse outcomes in chronic cardiac and non-cardiac conditions. Our study investigated whether troponin levels gathered from unselected blood samples taken during outpatient care are associated with adverse outcomes...
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MDPI AG
2023-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/24/17286 |
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| author | Celia Maria Cassaro Strunz Whady Hueb Paulo Cury Rezende Sabrina Pacheco do Amaral Vendramini Arthur Cicupira Rodrigues de Assis Alessandra Roggerio Maria Stanislavovna Tairova Marcela Francisca Silva Senili Avila Oliveira Gyovanna de Cassia Agreste Kisser Roberto Kalil Filho |
| author_facet | Celia Maria Cassaro Strunz Whady Hueb Paulo Cury Rezende Sabrina Pacheco do Amaral Vendramini Arthur Cicupira Rodrigues de Assis Alessandra Roggerio Maria Stanislavovna Tairova Marcela Francisca Silva Senili Avila Oliveira Gyovanna de Cassia Agreste Kisser Roberto Kalil Filho |
| author_sort | Celia Maria Cassaro Strunz |
| collection | DOAJ |
| description | Numerous studies have been published suggesting that troponin levels are related to adverse outcomes in chronic cardiac and non-cardiac conditions. Our study investigated whether troponin levels gathered from unselected blood samples taken during outpatient care are associated with adverse outcomes in a population with stable coronary artery disease. In a cohort of 949 patients with stable coronary artery disease, an average age of 67.5 ± 9.5 years, 69.5% male, 52.1% diabetics, 51.6% with previous myocardial infarction, and 57.9% with triple-vessel disease, 21.7% of patients encountered new events during an average period of monitoring of 2.07 ± 0.81 years. Troponin I/99th percentile categorized into tertiles emerged as an independent predictor of death and combined events risk (hazard ratio: 2.02 (1.13–3.60), <i>p</i> = 0.017; 2.30 (1.37–3.88, <i>p</i> = 0.002, respectively). A troponin ratio > 0.24 was able to identify 53.3% of patients at risk of death and heart failure hospitalization. In patients with stable coronary artery disease who are adherent to treatment, troponin levels are independently associated with death and heart failure hospitalization in a medium-term follow-up. |
| first_indexed | 2024-03-08T20:41:35Z |
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| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-08T20:41:35Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-2bdd9cdfd9c246258096209c10a602b32023-12-22T14:13:55ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-12-0124241728610.3390/ijms242417286High-Sensitivity Troponin I and Cardiovascular Events in Stable Coronary Artery Disease: Insights from a Longitudinal Outpatient StudyCelia Maria Cassaro Strunz0Whady Hueb1Paulo Cury Rezende2Sabrina Pacheco do Amaral Vendramini3Arthur Cicupira Rodrigues de Assis4Alessandra Roggerio5Maria Stanislavovna Tairova6Marcela Francisca Silva7Senili Avila Oliveira8Gyovanna de Cassia Agreste Kisser9Roberto Kalil Filho10Clinical Laboratory, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo 05403-900, SP, BrazilClinical Division, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo 05403-900, SP, BrazilClinical Division, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo 05403-900, SP, BrazilClinical Laboratory, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo 05403-900, SP, BrazilClinical Division, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo 05403-900, SP, BrazilClinical Laboratory, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo 05403-900, SP, BrazilClinical Division, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo 05403-900, SP, BrazilClinical Division, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo 05403-900, SP, BrazilClinical Laboratory, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo 05403-900, SP, BrazilClinical Laboratory, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo 05403-900, SP, BrazilClinical Division, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo 05403-900, SP, BrazilNumerous studies have been published suggesting that troponin levels are related to adverse outcomes in chronic cardiac and non-cardiac conditions. Our study investigated whether troponin levels gathered from unselected blood samples taken during outpatient care are associated with adverse outcomes in a population with stable coronary artery disease. In a cohort of 949 patients with stable coronary artery disease, an average age of 67.5 ± 9.5 years, 69.5% male, 52.1% diabetics, 51.6% with previous myocardial infarction, and 57.9% with triple-vessel disease, 21.7% of patients encountered new events during an average period of monitoring of 2.07 ± 0.81 years. Troponin I/99th percentile categorized into tertiles emerged as an independent predictor of death and combined events risk (hazard ratio: 2.02 (1.13–3.60), <i>p</i> = 0.017; 2.30 (1.37–3.88, <i>p</i> = 0.002, respectively). A troponin ratio > 0.24 was able to identify 53.3% of patients at risk of death and heart failure hospitalization. In patients with stable coronary artery disease who are adherent to treatment, troponin levels are independently associated with death and heart failure hospitalization in a medium-term follow-up.https://www.mdpi.com/1422-0067/24/24/17286high-sensitivity troponin IcTnI/99th tertilesstable coronary artery diseasecardiovascular events |
| spellingShingle | Celia Maria Cassaro Strunz Whady Hueb Paulo Cury Rezende Sabrina Pacheco do Amaral Vendramini Arthur Cicupira Rodrigues de Assis Alessandra Roggerio Maria Stanislavovna Tairova Marcela Francisca Silva Senili Avila Oliveira Gyovanna de Cassia Agreste Kisser Roberto Kalil Filho High-Sensitivity Troponin I and Cardiovascular Events in Stable Coronary Artery Disease: Insights from a Longitudinal Outpatient Study International Journal of Molecular Sciences high-sensitivity troponin I cTnI/99th tertiles stable coronary artery disease cardiovascular events |
| title | High-Sensitivity Troponin I and Cardiovascular Events in Stable Coronary Artery Disease: Insights from a Longitudinal Outpatient Study |
| title_full | High-Sensitivity Troponin I and Cardiovascular Events in Stable Coronary Artery Disease: Insights from a Longitudinal Outpatient Study |
| title_fullStr | High-Sensitivity Troponin I and Cardiovascular Events in Stable Coronary Artery Disease: Insights from a Longitudinal Outpatient Study |
| title_full_unstemmed | High-Sensitivity Troponin I and Cardiovascular Events in Stable Coronary Artery Disease: Insights from a Longitudinal Outpatient Study |
| title_short | High-Sensitivity Troponin I and Cardiovascular Events in Stable Coronary Artery Disease: Insights from a Longitudinal Outpatient Study |
| title_sort | high sensitivity troponin i and cardiovascular events in stable coronary artery disease insights from a longitudinal outpatient study |
| topic | high-sensitivity troponin I cTnI/99th tertiles stable coronary artery disease cardiovascular events |
| url | https://www.mdpi.com/1422-0067/24/24/17286 |
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