CpG content in the Zika virus genome affects infection phenotypes in the adult brain and fetal lymph nodes

CpG content in the Zika virus genome affects infection phenotypes in the adult brain and fetal lymph nodes

Increasing the number of CpG dinucleotides in RNA viral genomes, while preserving the original amino acid composition, leads to impaired infection which does not cause disease. Beneficially, impaired infection evokes antiviral host immune responses providing a cutting-edge vaccine approach. For exam...

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Bibliographic Details
Main Authors:	Daniel Udenze, Ivan Trus, Nathalie Berube, Uladzimir Karniychuk
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-08-01
Series:	Frontiers in Immunology
Subjects:	CpG CpG recoded virus flavivirus Zika virus vaccine viral evolution
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.943481/full

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