Association of Cerebral Ischemia With Corneal Nerve Loss and Brain Atrophy in MCI and Dementia
IntroductionThis study assessed the association of cerebral ischemia with neurodegeneration in mild cognitive impairment (MCI) and dementia.MethodsSubjects with MCI, dementia and controls underwent assessment of cognitive function, severity of brain ischemia, MRI brain volumetry and corneal confocal...
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Frontiers Media S.A.
2021-06-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2021.690896/full |
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| author | Georgios Ponirakis Georgios Ponirakis Ahmed Elsotouhy Ahmed Elsotouhy Hanadi Al Hamad Surjith Vattoth Ioannis N. Petropoulos Adnan Khan Hoda Gad Fatima Al-Khayat Mani Chandran Marwan Ramadan Marwa Elorrabi Masharig Gadelseed Rhia Tosino Priya V. Gawhale Maryam Alobaidi Shafi Khan Pravija Manikoth Yasmin H. M. Abdelrahim Noushad Thodi Hamad Almuhannadi Salma Al-Mohannadi Fatema AlMarri Murtaza Qazi Ahmed Own Ziyad R. Mahfoud Ashfaq Shuaib Rayaz A. Malik Rayaz A. Malik Rayaz A. Malik |
| author_facet | Georgios Ponirakis Georgios Ponirakis Ahmed Elsotouhy Ahmed Elsotouhy Hanadi Al Hamad Surjith Vattoth Ioannis N. Petropoulos Adnan Khan Hoda Gad Fatima Al-Khayat Mani Chandran Marwan Ramadan Marwa Elorrabi Masharig Gadelseed Rhia Tosino Priya V. Gawhale Maryam Alobaidi Shafi Khan Pravija Manikoth Yasmin H. M. Abdelrahim Noushad Thodi Hamad Almuhannadi Salma Al-Mohannadi Fatema AlMarri Murtaza Qazi Ahmed Own Ziyad R. Mahfoud Ashfaq Shuaib Rayaz A. Malik Rayaz A. Malik Rayaz A. Malik |
| author_sort | Georgios Ponirakis |
| collection | DOAJ |
| description | IntroductionThis study assessed the association of cerebral ischemia with neurodegeneration in mild cognitive impairment (MCI) and dementia.MethodsSubjects with MCI, dementia and controls underwent assessment of cognitive function, severity of brain ischemia, MRI brain volumetry and corneal confocal microscopy.ResultsOf 63 subjects with MCI (n = 44) and dementia (n = 19), 11 had no ischemia, 32 had subcortical ischemia and 20 had both subcortical and cortical ischemia. Brain volume and corneal nerve measures were comparable between subjects with subcortical ischemia and no ischemia. However, subjects with subcortical and cortical ischemia had a lower hippocampal volume (P < 0.01), corneal nerve fiber length (P < 0.05) and larger ventricular volume (P < 0.05) compared to those with subcortical ischemia and lower corneal nerve fiber density (P < 0.05) compared to those without ischemia.DiscussionCerebral ischemia was associated with cognitive impairment, brain atrophy and corneal nerve loss in MCI and dementia. |
| first_indexed | 2024-12-19T10:43:48Z |
| format | Article |
| id | doaj.art-2be29a417c024714a48b80efc4fad156 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-19T10:43:48Z |
| publishDate | 2021-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-2be29a417c024714a48b80efc4fad1562022-12-21T20:25:21ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2021-06-011510.3389/fnins.2021.690896690896Association of Cerebral Ischemia With Corneal Nerve Loss and Brain Atrophy in MCI and DementiaGeorgios Ponirakis0Georgios Ponirakis1Ahmed Elsotouhy2Ahmed Elsotouhy3Hanadi Al Hamad4Surjith Vattoth5Ioannis N. Petropoulos6Adnan Khan7Hoda Gad8Fatima Al-Khayat9Mani Chandran10Marwan Ramadan11Marwa Elorrabi12Masharig Gadelseed13Rhia Tosino14Priya V. Gawhale15Maryam Alobaidi16Shafi Khan17Pravija Manikoth18Yasmin H. M. Abdelrahim19Noushad Thodi20Hamad Almuhannadi21Salma Al-Mohannadi22Fatema AlMarri23Murtaza Qazi24Ahmed Own25Ziyad R. Mahfoud26Ashfaq Shuaib27Rayaz A. Malik28Rayaz A. Malik29Rayaz A. Malik30Department of Medicine, Weill Cornell Medicine-Qatar, Qatar Foundation, Doha, QatarFaculty of Science and Engineering, Manchester Metropolitan University, Manchester, United KingdomDepartment of Medicine, Weill Cornell Medicine-Qatar, Qatar Foundation, Doha, QatarNeuroradiology, Hamad General Hospital, Hamad Medical Corporation, Doha, QatarGeriatric and Memory Clinic, Rumailah Hospital, Hamad Medical Corporation, Doha, QatarDepartment of Radiology, University of Arkansas for Medical Sciences, Little Rock, AR, United StatesDepartment of Medicine, Weill Cornell Medicine-Qatar, Qatar Foundation, Doha, QatarDepartment of Medicine, Weill Cornell Medicine-Qatar, Qatar Foundation, Doha, QatarDepartment of Medicine, Weill Cornell Medicine-Qatar, Qatar Foundation, Doha, QatarDepartment of Medicine, Weill Cornell Medicine-Qatar, Qatar Foundation, Doha, QatarGeriatric and Memory Clinic, Rumailah Hospital, Hamad Medical Corporation, Doha, QatarGeriatric and Memory Clinic, Rumailah Hospital, Hamad Medical Corporation, Doha, QatarGeriatric and Memory Clinic, Rumailah Hospital, Hamad Medical Corporation, Doha, QatarGeriatric and Memory Clinic, Rumailah Hospital, Hamad Medical Corporation, Doha, QatarGeriatric and Memory Clinic, Rumailah Hospital, Hamad Medical Corporation, Doha, QatarGeriatric and Memory Clinic, Rumailah Hospital, Hamad Medical Corporation, Doha, QatarGeriatric and Memory Clinic, Rumailah Hospital, Hamad Medical Corporation, Doha, QatarGeriatric and Memory Clinic, Rumailah Hospital, Hamad Medical Corporation, Doha, QatarGeriatric and Memory Clinic, Rumailah Hospital, Hamad Medical Corporation, Doha, QatarGeriatric and Memory Clinic, Rumailah Hospital, Hamad Medical Corporation, Doha, QatarMagnetic Resonance Imaging Unit, Rumailah Hospital, Hamad Medical Corporation, Doha, QatarDepartment of Medicine, Weill Cornell Medicine-Qatar, Qatar Foundation, Doha, QatarDepartment of Medicine, Weill Cornell Medicine-Qatar, Qatar Foundation, Doha, QatarDepartment of Medicine, Weill Cornell Medicine-Qatar, Qatar Foundation, Doha, QatarDepartment of Medicine, Weill Cornell Medicine-Qatar, Qatar Foundation, Doha, QatarNeuroradiology, Hamad General Hospital, Hamad Medical Corporation, Doha, QatarDepartment of Medicine, Weill Cornell Medicine-Qatar, Qatar Foundation, Doha, QatarDepartment of Medicine, University of Alberta, Edmonton, AB, CanadaDepartment of Medicine, Weill Cornell Medicine-Qatar, Qatar Foundation, Doha, QatarFaculty of Science and Engineering, Manchester Metropolitan University, Manchester, United KingdomInstitute of Cardiovascular Science, University of Manchester, Manchester, United KingdomIntroductionThis study assessed the association of cerebral ischemia with neurodegeneration in mild cognitive impairment (MCI) and dementia.MethodsSubjects with MCI, dementia and controls underwent assessment of cognitive function, severity of brain ischemia, MRI brain volumetry and corneal confocal microscopy.ResultsOf 63 subjects with MCI (n = 44) and dementia (n = 19), 11 had no ischemia, 32 had subcortical ischemia and 20 had both subcortical and cortical ischemia. Brain volume and corneal nerve measures were comparable between subjects with subcortical ischemia and no ischemia. However, subjects with subcortical and cortical ischemia had a lower hippocampal volume (P < 0.01), corneal nerve fiber length (P < 0.05) and larger ventricular volume (P < 0.05) compared to those with subcortical ischemia and lower corneal nerve fiber density (P < 0.05) compared to those without ischemia.DiscussionCerebral ischemia was associated with cognitive impairment, brain atrophy and corneal nerve loss in MCI and dementia.https://www.frontiersin.org/articles/10.3389/fnins.2021.690896/fullischemic lesionssurrogate markercorneal confocal microscopycorneal nerve fibersbrain atrophydementia |
| spellingShingle | Georgios Ponirakis Georgios Ponirakis Ahmed Elsotouhy Ahmed Elsotouhy Hanadi Al Hamad Surjith Vattoth Ioannis N. Petropoulos Adnan Khan Hoda Gad Fatima Al-Khayat Mani Chandran Marwan Ramadan Marwa Elorrabi Masharig Gadelseed Rhia Tosino Priya V. Gawhale Maryam Alobaidi Shafi Khan Pravija Manikoth Yasmin H. M. Abdelrahim Noushad Thodi Hamad Almuhannadi Salma Al-Mohannadi Fatema AlMarri Murtaza Qazi Ahmed Own Ziyad R. Mahfoud Ashfaq Shuaib Rayaz A. Malik Rayaz A. Malik Rayaz A. Malik Association of Cerebral Ischemia With Corneal Nerve Loss and Brain Atrophy in MCI and Dementia Frontiers in Neuroscience ischemic lesions surrogate marker corneal confocal microscopy corneal nerve fibers brain atrophy dementia |
| title | Association of Cerebral Ischemia With Corneal Nerve Loss and Brain Atrophy in MCI and Dementia |
| title_full | Association of Cerebral Ischemia With Corneal Nerve Loss and Brain Atrophy in MCI and Dementia |
| title_fullStr | Association of Cerebral Ischemia With Corneal Nerve Loss and Brain Atrophy in MCI and Dementia |
| title_full_unstemmed | Association of Cerebral Ischemia With Corneal Nerve Loss and Brain Atrophy in MCI and Dementia |
| title_short | Association of Cerebral Ischemia With Corneal Nerve Loss and Brain Atrophy in MCI and Dementia |
| title_sort | association of cerebral ischemia with corneal nerve loss and brain atrophy in mci and dementia |
| topic | ischemic lesions surrogate marker corneal confocal microscopy corneal nerve fibers brain atrophy dementia |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2021.690896/full |
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