Assessment of autoantibodies in paediatric population with primary immunodeficiencies: a pilot study
Abstract Background The correlation between primary immunodeficiencies (PIDs) and autoimmunity shows ethnic and geographical diversity. The aim of our study was to accumulate more data in paediatric PID population. Methods 58 children aged 1–17 and with PID (study group) and 14 age-matched immunocom...
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| Format: | Article |
| Language: | English |
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BMC
2023-06-01
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| Series: | BMC Immunology |
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| Online Access: | https://doi.org/10.1186/s12865-023-00543-6 |
| _version_ | 1797811530870292480 |
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| author | Karolina Pieniawska-Śmiech Aleksandra Lewandowicz-Uszyńska Magdalena Zemelka-Wiacek Marek Jutel |
| author_facet | Karolina Pieniawska-Śmiech Aleksandra Lewandowicz-Uszyńska Magdalena Zemelka-Wiacek Marek Jutel |
| author_sort | Karolina Pieniawska-Śmiech |
| collection | DOAJ |
| description | Abstract Background The correlation between primary immunodeficiencies (PIDs) and autoimmunity shows ethnic and geographical diversity. The aim of our study was to accumulate more data in paediatric PID population. Methods 58 children aged 1–17 and with PID (study group) and 14 age-matched immunocompetent individuals (control group) were included in the study. Serum levels of 17 different specific IgG antibodies against autoantigens were measured by means of a quantitative enzyme immunoassay. Immunoglobulin levels were analysed in relation to a detailed medical examination. Results Autoantibodies against one or more antigens were detected in the sera of 24.14% (n = 14) subjects in the study group. The most frequent were anti-thyroid peroxidase (anti-TPO) antibodies (n = 8; 13.8%). Anti-TPO antibody levels were elevated more often in PID patients with a positive family history of autoimmune diseases (p = 0.04). The screening for anti-deamidated gliadin peptide (DGP) and anti-tissue transglutaminase (tTG) antibodies in our series allowed identifying two previously undiagnosed cases of coeliac disease in PID patients. There was no statistically significant difference between the study and the control group in terms of the autoantibodies prevalence. Conclusions This study provides data on the prevalence of autoantibodies in paediatric population diagnosed with PID. Selected autoantibodies (i.e. anti-tTG, anti-DGP) might be useful for the screening of PID to avoid the delay of diagnosis of an autoimmune disease. |
| first_indexed | 2024-03-13T07:25:06Z |
| format | Article |
| id | doaj.art-2be2a4509882408aa23a9d60b4b43512 |
| institution | Directory Open Access Journal |
| issn | 1471-2172 |
| language | English |
| last_indexed | 2024-03-13T07:25:06Z |
| publishDate | 2023-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Immunology |
| spelling | doaj.art-2be2a4509882408aa23a9d60b4b435122023-06-04T11:24:45ZengBMCBMC Immunology1471-21722023-06-0124111010.1186/s12865-023-00543-6Assessment of autoantibodies in paediatric population with primary immunodeficiencies: a pilot studyKarolina Pieniawska-Śmiech0Aleksandra Lewandowicz-Uszyńska1Magdalena Zemelka-Wiacek2Marek Jutel3Department of Clinical Immunology, Wroclaw Medical UniversityDepartment of Clinical Immunology and Paediatrics, Provincial Hospital J.GromkowskiDepartment of Clinical Immunology, Wroclaw Medical UniversityDepartment of Clinical Immunology, Wroclaw Medical UniversityAbstract Background The correlation between primary immunodeficiencies (PIDs) and autoimmunity shows ethnic and geographical diversity. The aim of our study was to accumulate more data in paediatric PID population. Methods 58 children aged 1–17 and with PID (study group) and 14 age-matched immunocompetent individuals (control group) were included in the study. Serum levels of 17 different specific IgG antibodies against autoantigens were measured by means of a quantitative enzyme immunoassay. Immunoglobulin levels were analysed in relation to a detailed medical examination. Results Autoantibodies against one or more antigens were detected in the sera of 24.14% (n = 14) subjects in the study group. The most frequent were anti-thyroid peroxidase (anti-TPO) antibodies (n = 8; 13.8%). Anti-TPO antibody levels were elevated more often in PID patients with a positive family history of autoimmune diseases (p = 0.04). The screening for anti-deamidated gliadin peptide (DGP) and anti-tissue transglutaminase (tTG) antibodies in our series allowed identifying two previously undiagnosed cases of coeliac disease in PID patients. There was no statistically significant difference between the study and the control group in terms of the autoantibodies prevalence. Conclusions This study provides data on the prevalence of autoantibodies in paediatric population diagnosed with PID. Selected autoantibodies (i.e. anti-tTG, anti-DGP) might be useful for the screening of PID to avoid the delay of diagnosis of an autoimmune disease.https://doi.org/10.1186/s12865-023-00543-6AutoantibodyAutoimmunityCoeliac diseaseImmune dysregulationInborn errors of immunityPrimary immunodeficiency |
| spellingShingle | Karolina Pieniawska-Śmiech Aleksandra Lewandowicz-Uszyńska Magdalena Zemelka-Wiacek Marek Jutel Assessment of autoantibodies in paediatric population with primary immunodeficiencies: a pilot study BMC Immunology Autoantibody Autoimmunity Coeliac disease Immune dysregulation Inborn errors of immunity Primary immunodeficiency |
| title | Assessment of autoantibodies in paediatric population with primary immunodeficiencies: a pilot study |
| title_full | Assessment of autoantibodies in paediatric population with primary immunodeficiencies: a pilot study |
| title_fullStr | Assessment of autoantibodies in paediatric population with primary immunodeficiencies: a pilot study |
| title_full_unstemmed | Assessment of autoantibodies in paediatric population with primary immunodeficiencies: a pilot study |
| title_short | Assessment of autoantibodies in paediatric population with primary immunodeficiencies: a pilot study |
| title_sort | assessment of autoantibodies in paediatric population with primary immunodeficiencies a pilot study |
| topic | Autoantibody Autoimmunity Coeliac disease Immune dysregulation Inborn errors of immunity Primary immunodeficiency |
| url | https://doi.org/10.1186/s12865-023-00543-6 |
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