Reduced reward anticipation in youth at high-risk for unipolar depression: A preliminary study
Offspring of depressed parents are at risk for depression and recent evidence suggests that reduced positive affect (PA) may be a marker of risk. We investigated whether self-reports of PA and fMRI-measured striatal response to reward, a neural correlate of PA, are reduced in adolescent youth at hig...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2014-04-01
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| Series: | Developmental Cognitive Neuroscience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S187892931300100X |
| _version_ | 1819057235200835584 |
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| author | Thomas M. Olino Dana L. McMakin Judith K. Morgan Jennifer S. Silk Boris Birmaher David A. Axelson Douglas E. Williamson Ronald E. Dahl Neal D. Ryan Erika E. Forbes |
| author_facet | Thomas M. Olino Dana L. McMakin Judith K. Morgan Jennifer S. Silk Boris Birmaher David A. Axelson Douglas E. Williamson Ronald E. Dahl Neal D. Ryan Erika E. Forbes |
| author_sort | Thomas M. Olino |
| collection | DOAJ |
| description | Offspring of depressed parents are at risk for depression and recent evidence suggests that reduced positive affect (PA) may be a marker of risk. We investigated whether self-reports of PA and fMRI-measured striatal response to reward, a neural correlate of PA, are reduced in adolescent youth at high familial risk for depression (HR) relative to youth at low familial risk for depression (LR). Functional magnetic resonance imaging assessments were conducted with 14 HR and 12 LR youth. All youth completed an ecological momentary assessment protocol to measure PA in natural settings and a self-report measure of depression symptomatology. Analyses found that HR youth demonstrated lower striatal response than LR youth during both reward anticipation and outcome. However, after controlling for youth self-reports of depression, HR youth demonstrated lower striatal response than LR youth only during reward anticipation. No significant differences were found between HR and LR youth on subjective ratings of PA or depressive symptoms. Results are consistent with previous findings that reduced reward response is a marker of risk for depression, particularly during reward anticipation, even in the absence of (or accounting for) disrupted subjective mood. Further examinations of prospective associations between reward response and depression onset are needed. |
| first_indexed | 2024-12-21T13:36:05Z |
| format | Article |
| id | doaj.art-2be56b790a884d5197ee985d26ae9b42 |
| institution | Directory Open Access Journal |
| issn | 1878-9293 1878-9307 |
| language | English |
| last_indexed | 2024-12-21T13:36:05Z |
| publishDate | 2014-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Developmental Cognitive Neuroscience |
| spelling | doaj.art-2be56b790a884d5197ee985d26ae9b422022-12-21T19:02:10ZengElsevierDevelopmental Cognitive Neuroscience1878-92931878-93072014-04-018C556410.1016/j.dcn.2013.11.005Reduced reward anticipation in youth at high-risk for unipolar depression: A preliminary studyThomas M. Olino0Dana L. McMakin1Judith K. Morgan2Jennifer S. Silk3Boris Birmaher4David A. Axelson5Douglas E. Williamson6Ronald E. Dahl7Neal D. Ryan8Erika E. Forbes9University of Pittsburgh, United StatesUniversity of Pittsburgh, United StatesUniversity of Pittsburgh, United StatesUniversity of Pittsburgh, United StatesUniversity of Pittsburgh, United StatesUniversity of Pittsburgh, United StatesUniversity of Texas Health Science Center, United StatesUniversity of California-Berkeley, United StatesUniversity of Pittsburgh, United StatesUniversity of Pittsburgh, United StatesOffspring of depressed parents are at risk for depression and recent evidence suggests that reduced positive affect (PA) may be a marker of risk. We investigated whether self-reports of PA and fMRI-measured striatal response to reward, a neural correlate of PA, are reduced in adolescent youth at high familial risk for depression (HR) relative to youth at low familial risk for depression (LR). Functional magnetic resonance imaging assessments were conducted with 14 HR and 12 LR youth. All youth completed an ecological momentary assessment protocol to measure PA in natural settings and a self-report measure of depression symptomatology. Analyses found that HR youth demonstrated lower striatal response than LR youth during both reward anticipation and outcome. However, after controlling for youth self-reports of depression, HR youth demonstrated lower striatal response than LR youth only during reward anticipation. No significant differences were found between HR and LR youth on subjective ratings of PA or depressive symptoms. Results are consistent with previous findings that reduced reward response is a marker of risk for depression, particularly during reward anticipation, even in the absence of (or accounting for) disrupted subjective mood. Further examinations of prospective associations between reward response and depression onset are needed.http://www.sciencedirect.com/science/article/pii/S187892931300100XDepressionHigh-riskReward functionPositive affectfMRI |
| spellingShingle | Thomas M. Olino Dana L. McMakin Judith K. Morgan Jennifer S. Silk Boris Birmaher David A. Axelson Douglas E. Williamson Ronald E. Dahl Neal D. Ryan Erika E. Forbes Reduced reward anticipation in youth at high-risk for unipolar depression: A preliminary study Developmental Cognitive Neuroscience Depression High-risk Reward function Positive affect fMRI |
| title | Reduced reward anticipation in youth at high-risk for unipolar depression: A preliminary study |
| title_full | Reduced reward anticipation in youth at high-risk for unipolar depression: A preliminary study |
| title_fullStr | Reduced reward anticipation in youth at high-risk for unipolar depression: A preliminary study |
| title_full_unstemmed | Reduced reward anticipation in youth at high-risk for unipolar depression: A preliminary study |
| title_short | Reduced reward anticipation in youth at high-risk for unipolar depression: A preliminary study |
| title_sort | reduced reward anticipation in youth at high risk for unipolar depression a preliminary study |
| topic | Depression High-risk Reward function Positive affect fMRI |
| url | http://www.sciencedirect.com/science/article/pii/S187892931300100X |
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