Comparative Transcriptome Analysis in Monocyte-Derived Macrophages of Asymptomatic <i>GBA</i> Mutation Carriers and Patients with GBA-Associated Parkinson’s Disease

Comparative Transcriptome Analysis in Monocyte-Derived Macrophages of Asymptomatic <i>GBA</i> Mutation Carriers and Patients with GBA-Associated Parkinson’s Disease

Mutations of the <i>GBA</i> gene, encoding for lysosomal enzyme glucocerebrosidase (GCase), are the greatest genetic risk factor for Parkinson’s disease (PD) with frequency between 5% and 20% across the world. N370S and L444P are the two most common mutations in the <i>GBA</i>...

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Bibliographic Details
Main Authors: Tatiana Usenko, Anastasia Bezrukova, Katerina Basharova, Alexandra Panteleeva, Mikhail Nikolaev, Alena Kopytova, Irina Miliukhina, Anton Emelyanov, Ekaterina Zakharova, Sofya Pchelina
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Genes
Subjects:
Parkinson’s disease
<i>GBA</i>
macrophages
RNA-seq
transcriptome
Online Access:https://www.mdpi.com/2073-4425/12/10/1545

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