Prevalence of osteoporosis in patients with diabetes mellitus: a systematic review and meta-analysis of observational studies
Abstract Background Osteoporosis (OP) and diabetes mellitus (DM) are two major healthcare issues in the world. Numerous population based-studies have reported an increased prevalence of OP among individuals with DM, though, estimates vary significantly. Purpose The objective of this study is to esti...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-01-01
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| Series: | BMC Endocrine Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12902-022-01260-8 |
| _version_ | 1828069539739336704 |
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| author | Xueying Liu Fuhua Chen Lei Liu Qiu Zhang |
| author_facet | Xueying Liu Fuhua Chen Lei Liu Qiu Zhang |
| author_sort | Xueying Liu |
| collection | DOAJ |
| description | Abstract Background Osteoporosis (OP) and diabetes mellitus (DM) are two major healthcare issues in the world. Numerous population based-studies have reported an increased prevalence of OP among individuals with DM, though, estimates vary significantly. Purpose The objective of this study is to estimate the prevalence of OP in patients with DM. Methods To identify relevant literature, PubMed, Embase, Medline, CBM and Cochrane Library were searched for studies published from inception till July 2022, The search was conducted, and studies were included without countries and language restrictions. For full-text articles included in the study, the references were also independently searched. Random inverse variance-weighted models were used by Stata version 17.0 to estimate the prevalence of OP in patients with diabetes across studies. The heterogeneity was examined with I2 via the χ2 test on Cochrane’s Q statistic. Subgroup analysis and meta-regression were used to explore potential sources of heterogeneity. Egger’s test was used to assess publication bias. Results A high OP prevalence of 27.67% (95% confidence interval (CI) 21.37-33.98%) was found in a pooled analysis of 21 studies involving 11,603 T2DM patients. Methodological value of the included articles was high, with only three medium-quality studies and no low-quality studies. A significantly high heterogeneity (I2 = 98.5%) was observed. Conclusions Worldwide, a high prevalence of OP was found in patients with T2DM. Therefore, strong measures to prevent and treat osteoporosis in diabetic patients are required. Trial registration This study has been registered on PROSPERO, number CRD42021286580 . |
| first_indexed | 2024-04-11T00:21:37Z |
| format | Article |
| id | doaj.art-2bea7ab8ea954ea794a387a96754f42b |
| institution | Directory Open Access Journal |
| issn | 1472-6823 |
| language | English |
| last_indexed | 2024-04-11T00:21:37Z |
| publishDate | 2023-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj.art-2bea7ab8ea954ea794a387a96754f42b2023-01-08T12:14:05ZengBMCBMC Endocrine Disorders1472-68232023-01-0123111210.1186/s12902-022-01260-8Prevalence of osteoporosis in patients with diabetes mellitus: a systematic review and meta-analysis of observational studiesXueying Liu0Fuhua Chen1Lei Liu2Qiu Zhang3Department of Endocrinology, First Affiliated Hospital of Anhui Medical UniversityDepartment of Endocrinology, First Affiliated Hospital of Anhui Medical UniversityDepartment of Endocrinology, First Affiliated Hospital of Anhui Medical UniversityDepartment of Endocrinology, First Affiliated Hospital of Anhui Medical UniversityAbstract Background Osteoporosis (OP) and diabetes mellitus (DM) are two major healthcare issues in the world. Numerous population based-studies have reported an increased prevalence of OP among individuals with DM, though, estimates vary significantly. Purpose The objective of this study is to estimate the prevalence of OP in patients with DM. Methods To identify relevant literature, PubMed, Embase, Medline, CBM and Cochrane Library were searched for studies published from inception till July 2022, The search was conducted, and studies were included without countries and language restrictions. For full-text articles included in the study, the references were also independently searched. Random inverse variance-weighted models were used by Stata version 17.0 to estimate the prevalence of OP in patients with diabetes across studies. The heterogeneity was examined with I2 via the χ2 test on Cochrane’s Q statistic. Subgroup analysis and meta-regression were used to explore potential sources of heterogeneity. Egger’s test was used to assess publication bias. Results A high OP prevalence of 27.67% (95% confidence interval (CI) 21.37-33.98%) was found in a pooled analysis of 21 studies involving 11,603 T2DM patients. Methodological value of the included articles was high, with only three medium-quality studies and no low-quality studies. A significantly high heterogeneity (I2 = 98.5%) was observed. Conclusions Worldwide, a high prevalence of OP was found in patients with T2DM. Therefore, strong measures to prevent and treat osteoporosis in diabetic patients are required. Trial registration This study has been registered on PROSPERO, number CRD42021286580 .https://doi.org/10.1186/s12902-022-01260-8OsteoporosisDiabetes mellitusSystematic reviewMeta-analysisObservational studies |
| spellingShingle | Xueying Liu Fuhua Chen Lei Liu Qiu Zhang Prevalence of osteoporosis in patients with diabetes mellitus: a systematic review and meta-analysis of observational studies BMC Endocrine Disorders Osteoporosis Diabetes mellitus Systematic review Meta-analysis Observational studies |
| title | Prevalence of osteoporosis in patients with diabetes mellitus: a systematic review and meta-analysis of observational studies |
| title_full | Prevalence of osteoporosis in patients with diabetes mellitus: a systematic review and meta-analysis of observational studies |
| title_fullStr | Prevalence of osteoporosis in patients with diabetes mellitus: a systematic review and meta-analysis of observational studies |
| title_full_unstemmed | Prevalence of osteoporosis in patients with diabetes mellitus: a systematic review and meta-analysis of observational studies |
| title_short | Prevalence of osteoporosis in patients with diabetes mellitus: a systematic review and meta-analysis of observational studies |
| title_sort | prevalence of osteoporosis in patients with diabetes mellitus a systematic review and meta analysis of observational studies |
| topic | Osteoporosis Diabetes mellitus Systematic review Meta-analysis Observational studies |
| url | https://doi.org/10.1186/s12902-022-01260-8 |
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