Coumarin – benzimidazole hybrids: A review on diverse synthetic strategies
Benzimidazole and coumarin are highly significant pharmacophores in medicinal chemistry due to their numerous and compelling biological activities. It has been found that combining two or more pharmacophores in a single moiety can improve the efficiency and oral bioavailability and reduce the side e...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Results in Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715622003502 |
| _version_ | 1811178110740070400 |
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| author | C.G. Arya Munugala Chandrakanth K. Fabitha Neethu Mariam Thomas Rakendu N. Pramod Ramesh Gondru Janardhan Banothu |
| author_facet | C.G. Arya Munugala Chandrakanth K. Fabitha Neethu Mariam Thomas Rakendu N. Pramod Ramesh Gondru Janardhan Banothu |
| author_sort | C.G. Arya |
| collection | DOAJ |
| description | Benzimidazole and coumarin are highly significant pharmacophores in medicinal chemistry due to their numerous and compelling biological activities. It has been found that combining two or more pharmacophores in a single moiety can improve the efficiency and oral bioavailability and reduce the side effects when compared with the individual pharmacophores. Therefore, the synthesis and biological applications of hybrid molecules have gained considerable attention globally over the past few decades. In view of this, several researchers synthesized various coumarin-benzimidazole hybrids and studied their biological activities. Coumarin-benzimidazole hybrids have broadly categorized as fused and spacer-linked hybrids. Each of them has been further classified as coumarin-C3 benzimidazole hybrids, coumarin-C4 benzimidazole hybrids and coumarin-C5 benzimidazole hybrids etc. The present review focuses on various synthetic strategies for all the types of coumarin-benzimidazole hybrids, along with their metal complexes, in detail. We believe that this review assists the scientific community worldwide in successfully designing and developing drug candidates. |
| first_indexed | 2024-04-11T06:12:47Z |
| format | Article |
| id | doaj.art-2beb5edd26fd40ae8ffc77accb80f78f |
| institution | Directory Open Access Journal |
| issn | 2211-7156 |
| language | English |
| last_indexed | 2024-04-11T06:12:47Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Chemistry |
| spelling | doaj.art-2beb5edd26fd40ae8ffc77accb80f78f2022-12-22T04:41:09ZengElsevierResults in Chemistry2211-71562022-01-014100631Coumarin – benzimidazole hybrids: A review on diverse synthetic strategiesC.G. Arya0Munugala Chandrakanth1K. Fabitha2Neethu Mariam Thomas3Rakendu N. Pramod4Ramesh Gondru5Janardhan Banothu6Department of Chemistry, National Institute of Technology Calicut, Kozhikode, Kerala 673601, IndiaDepartment of Chemistry, National Institute of Technology Calicut, Kozhikode, Kerala 673601, IndiaDepartment of Chemistry, National Institute of Technology Calicut, Kozhikode, Kerala 673601, IndiaDepartment of Chemistry, National Institute of Technology Calicut, Kozhikode, Kerala 673601, IndiaDepartment of Chemistry, National Institute of Technology Calicut, Kozhikode, Kerala 673601, IndiaEnvironmental Monitoring & Exposure Assessment (Air) Laboratory, ICMR-NIREH, Bhopal, Madhya Pradesh 462030, India; Corresponding authors at: Department of Chemistry, Room No. 210(C), NIT Calicut, Kozhikode, Kerala 673601, India.Department of Chemistry, National Institute of Technology Calicut, Kozhikode, Kerala 673601, India; Corresponding authors at: Department of Chemistry, Room No. 210(C), NIT Calicut, Kozhikode, Kerala 673601, India.Benzimidazole and coumarin are highly significant pharmacophores in medicinal chemistry due to their numerous and compelling biological activities. It has been found that combining two or more pharmacophores in a single moiety can improve the efficiency and oral bioavailability and reduce the side effects when compared with the individual pharmacophores. Therefore, the synthesis and biological applications of hybrid molecules have gained considerable attention globally over the past few decades. In view of this, several researchers synthesized various coumarin-benzimidazole hybrids and studied their biological activities. Coumarin-benzimidazole hybrids have broadly categorized as fused and spacer-linked hybrids. Each of them has been further classified as coumarin-C3 benzimidazole hybrids, coumarin-C4 benzimidazole hybrids and coumarin-C5 benzimidazole hybrids etc. The present review focuses on various synthetic strategies for all the types of coumarin-benzimidazole hybrids, along with their metal complexes, in detail. We believe that this review assists the scientific community worldwide in successfully designing and developing drug candidates.http://www.sciencedirect.com/science/article/pii/S2211715622003502BenzimidazoleCoumarinCoumarin-benzimidazole hybridsMolecular hybridization |
| spellingShingle | C.G. Arya Munugala Chandrakanth K. Fabitha Neethu Mariam Thomas Rakendu N. Pramod Ramesh Gondru Janardhan Banothu Coumarin – benzimidazole hybrids: A review on diverse synthetic strategies Results in Chemistry Benzimidazole Coumarin Coumarin-benzimidazole hybrids Molecular hybridization |
| title | Coumarin – benzimidazole hybrids: A review on diverse synthetic strategies |
| title_full | Coumarin – benzimidazole hybrids: A review on diverse synthetic strategies |
| title_fullStr | Coumarin – benzimidazole hybrids: A review on diverse synthetic strategies |
| title_full_unstemmed | Coumarin – benzimidazole hybrids: A review on diverse synthetic strategies |
| title_short | Coumarin – benzimidazole hybrids: A review on diverse synthetic strategies |
| title_sort | coumarin benzimidazole hybrids a review on diverse synthetic strategies |
| topic | Benzimidazole Coumarin Coumarin-benzimidazole hybrids Molecular hybridization |
| url | http://www.sciencedirect.com/science/article/pii/S2211715622003502 |
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