Diagnostic Performance of Contrast-Enhanced Ultrasound in the Evaluation of Small Renal Masses: A Systematic Review and Meta-Analysis
Ultrasound (US) is a highly sensitive imaging tool in the detection of renal masses. However, the detection rate of small renal masses (SRMs) (<4 cm) is still limited. In this scenario, contrast-enhanced ultrasound (CEUS) is a relatively novel, but increasingly utilized, diagnostic modality which...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/10/2310 |
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| author | Antonio Tufano Luca Antonelli Giovanni Battista Di Pierro Rocco Simone Flammia Rocco Minelli Umberto Anceschi Costantino Leonardo Giorgio Franco Francesco Maria Drudi Vito Cantisani |
| author_facet | Antonio Tufano Luca Antonelli Giovanni Battista Di Pierro Rocco Simone Flammia Rocco Minelli Umberto Anceschi Costantino Leonardo Giorgio Franco Francesco Maria Drudi Vito Cantisani |
| author_sort | Antonio Tufano |
| collection | DOAJ |
| description | Ultrasound (US) is a highly sensitive imaging tool in the detection of renal masses. However, the detection rate of small renal masses (SRMs) (<4 cm) is still limited. In this scenario, contrast-enhanced ultrasound (CEUS) is a relatively novel, but increasingly utilized, diagnostic modality which aims to increase the overall diagnostic ability in the identification of SRMs. In consequence, we performed a systematic review (SR) and pooled meta-analysis to investigate the diagnostic performance of CEUS in the evaluation of SRMs confirmed by pathology. A SR up to April 2022 was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. The diagnostic performance of CEUS was evaluated basing on malignant vs. benign SMRs. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) from eligible studies were pooled, and summary receiver operating characteristic (SROC) curves were constructed for each endpoint. Overall, five qualified studies were deemed suitable for this meta-analysis. Finally, diagnostic performance of CEUS showed an accuracy of 0.93 in detecting malignant masses (sensitivity of 0.94, PPV of 0.95, specificity of 0.78, and NPV of 0.73). Taken together, CEUS may represent a promising minimally invasive diagnostic tool for characterization of SMRs, since it allows clinicians to identify malignant lesions. |
| first_indexed | 2024-03-09T20:23:04Z |
| format | Article |
| id | doaj.art-2bebeacd9f994e52ad3dd0ab90c99a4e |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T20:23:04Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-2bebeacd9f994e52ad3dd0ab90c99a4e2023-11-23T23:43:04ZengMDPI AGDiagnostics2075-44182022-09-011210231010.3390/diagnostics12102310Diagnostic Performance of Contrast-Enhanced Ultrasound in the Evaluation of Small Renal Masses: A Systematic Review and Meta-AnalysisAntonio Tufano0Luca Antonelli1Giovanni Battista Di Pierro2Rocco Simone Flammia3Rocco Minelli4Umberto Anceschi5Costantino Leonardo6Giorgio Franco7Francesco Maria Drudi8Vito Cantisani9Department of Maternal-Infant and Urological Sciences, “Sapienza” Rome University, Policlinico Umberto I Hospital, 00185 Rome, ItalyDepartment of Maternal-Infant and Urological Sciences, “Sapienza” Rome University, Policlinico Umberto I Hospital, 00185 Rome, ItalyDepartment of Maternal-Infant and Urological Sciences, “Sapienza” Rome University, Policlinico Umberto I Hospital, 00185 Rome, ItalyDepartment of Maternal-Infant and Urological Sciences, “Sapienza” Rome University, Policlinico Umberto I Hospital, 00185 Rome, ItalyDepartment Life and Health “V. Tiberio”, University of Molise, Francesco De Sanctis 1, 86100 Campobasso, ItalyDepartment of Urology, IRCCS “Regina Elena” National Cancer Institute, Via Elio Chianesi 53, 00144 Rome, ItalyDepartment of Maternal-Infant and Urological Sciences, “Sapienza” Rome University, Policlinico Umberto I Hospital, 00185 Rome, ItalyDepartment of Maternal-Infant and Urological Sciences, “Sapienza” Rome University, Policlinico Umberto I Hospital, 00185 Rome, ItalyDepartment of Radiological, Oncological and Pathobiological Sciences, Sapienza University of Rome, 00144 Rome, ItalyDepartment of Radiological, Oncological and Pathobiological Sciences, Sapienza University of Rome, 00144 Rome, ItalyUltrasound (US) is a highly sensitive imaging tool in the detection of renal masses. However, the detection rate of small renal masses (SRMs) (<4 cm) is still limited. In this scenario, contrast-enhanced ultrasound (CEUS) is a relatively novel, but increasingly utilized, diagnostic modality which aims to increase the overall diagnostic ability in the identification of SRMs. In consequence, we performed a systematic review (SR) and pooled meta-analysis to investigate the diagnostic performance of CEUS in the evaluation of SRMs confirmed by pathology. A SR up to April 2022 was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. The diagnostic performance of CEUS was evaluated basing on malignant vs. benign SMRs. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) from eligible studies were pooled, and summary receiver operating characteristic (SROC) curves were constructed for each endpoint. Overall, five qualified studies were deemed suitable for this meta-analysis. Finally, diagnostic performance of CEUS showed an accuracy of 0.93 in detecting malignant masses (sensitivity of 0.94, PPV of 0.95, specificity of 0.78, and NPV of 0.73). Taken together, CEUS may represent a promising minimally invasive diagnostic tool for characterization of SMRs, since it allows clinicians to identify malignant lesions.https://www.mdpi.com/2075-4418/12/10/2310contrast-enhanced ultrasound (CEUS)renal cancerrenal massessmall renal massessmall kidney massesperfusion |
| spellingShingle | Antonio Tufano Luca Antonelli Giovanni Battista Di Pierro Rocco Simone Flammia Rocco Minelli Umberto Anceschi Costantino Leonardo Giorgio Franco Francesco Maria Drudi Vito Cantisani Diagnostic Performance of Contrast-Enhanced Ultrasound in the Evaluation of Small Renal Masses: A Systematic Review and Meta-Analysis Diagnostics contrast-enhanced ultrasound (CEUS) renal cancer renal masses small renal masses small kidney masses perfusion |
| title | Diagnostic Performance of Contrast-Enhanced Ultrasound in the Evaluation of Small Renal Masses: A Systematic Review and Meta-Analysis |
| title_full | Diagnostic Performance of Contrast-Enhanced Ultrasound in the Evaluation of Small Renal Masses: A Systematic Review and Meta-Analysis |
| title_fullStr | Diagnostic Performance of Contrast-Enhanced Ultrasound in the Evaluation of Small Renal Masses: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Diagnostic Performance of Contrast-Enhanced Ultrasound in the Evaluation of Small Renal Masses: A Systematic Review and Meta-Analysis |
| title_short | Diagnostic Performance of Contrast-Enhanced Ultrasound in the Evaluation of Small Renal Masses: A Systematic Review and Meta-Analysis |
| title_sort | diagnostic performance of contrast enhanced ultrasound in the evaluation of small renal masses a systematic review and meta analysis |
| topic | contrast-enhanced ultrasound (CEUS) renal cancer renal masses small renal masses small kidney masses perfusion |
| url | https://www.mdpi.com/2075-4418/12/10/2310 |
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