RagC GTPase regulates mTOR to promote chemoresistance in senescence-like HepG2 cells

RagC GTPase regulates mTOR to promote chemoresistance in senescence-like HepG2 cells

Radiotherapy and chemotherapy can arrest cancer cells in a senescence-like state, which can lead to therapy resistance and cancer relapse. mTOR is hyperactivated in senescent cells but the mechanisms remain unclear. In this study, we examine the roles of several mTOR-regulated GTPases in senescence-...

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Bibliographic Details
Main Authors: Wei Jiang, Zhenglin Ou, Qin Zhu, Hongyan Zai
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Physiology
Subjects:
senescence
mTOR
GTPase
liver cancer
chemoresistance
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.949737/full

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