Imaging of Tauopathies with PET Ligands: State of the Art and Future Outlook
(1) Background: Tauopathies are a group of diseases characterized by the deposition of abnormal tau protein. They are distinguished into 3R, 4R, and 3R/4R tauopathies and also include Alzheimer’s disease (AD) and chronic traumatic encephalopathy (CTE). Positron emission tomography (PET) imaging repr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/10/1682 |
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| author | Miriam Conte Maria Silvia De Feo Marko Magdi Abdou Sidrak Ferdinando Corica Joana Gorica Giorgia Maria Granese Luca Filippi Giuseppe De Vincentis Viviana Frantellizzi |
| author_facet | Miriam Conte Maria Silvia De Feo Marko Magdi Abdou Sidrak Ferdinando Corica Joana Gorica Giorgia Maria Granese Luca Filippi Giuseppe De Vincentis Viviana Frantellizzi |
| author_sort | Miriam Conte |
| collection | DOAJ |
| description | (1) Background: Tauopathies are a group of diseases characterized by the deposition of abnormal tau protein. They are distinguished into 3R, 4R, and 3R/4R tauopathies and also include Alzheimer’s disease (AD) and chronic traumatic encephalopathy (CTE). Positron emission tomography (PET) imaging represents a pivotal instrument to guide clinicians. This systematic review aims to summarize the current and novel PET tracers. (2) Methods: Literature research was conducted on Pubmed, Scopus, Medline, Central, and the Web of Science using the query “pet ligands” and “tauopathies”. Articles published from January 2018 to 9 February, 2023, were searched. Only studies on the development of novel PET radiotracers for imaging in tauopathies or comparative studies between existing PET tracers were included. (3) Results: A total of 126 articles were found, as follows: 96 were identified from PubMed, 27 from Scopus, one on Central, two on Medline, and zero on the Web of Science. Twenty-four duplicated works were excluded, and 63 articles did not satisfy the inclusion criteria. The remaining 40 articles were included for quality assessment. (4) Conclusions: PET imaging represents a valid instrument capable of helping clinicians in diagnosis, but it is not always perfect in differential diagnosis, even if further investigations on humans for novel promising ligands are needed. |
| first_indexed | 2024-03-11T03:48:26Z |
| format | Article |
| id | doaj.art-2bed5443c4284830911ae758c4ef9222 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T03:48:26Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-2bed5443c4284830911ae758c4ef92222023-11-18T01:03:25ZengMDPI AGDiagnostics2075-44182023-05-011310168210.3390/diagnostics13101682Imaging of Tauopathies with PET Ligands: State of the Art and Future OutlookMiriam Conte0Maria Silvia De Feo1Marko Magdi Abdou Sidrak2Ferdinando Corica3Joana Gorica4Giorgia Maria Granese5Luca Filippi6Giuseppe De Vincentis7Viviana Frantellizzi8Department of Radiological Sciences, Oncology and Anatomo-Pathology, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Radiological Sciences, Oncology and Anatomo-Pathology, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Radiological Sciences, Oncology and Anatomo-Pathology, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Radiological Sciences, Oncology and Anatomo-Pathology, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Radiological Sciences, Oncology and Anatomo-Pathology, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Radiological Sciences, Oncology and Anatomo-Pathology, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Nuclear Medicine, Santa Maria Goretti Hospital, 00410 Latina, ItalyDepartment of Radiological Sciences, Oncology and Anatomo-Pathology, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Radiological Sciences, Oncology and Anatomo-Pathology, Sapienza University of Rome, 00161 Rome, Italy(1) Background: Tauopathies are a group of diseases characterized by the deposition of abnormal tau protein. They are distinguished into 3R, 4R, and 3R/4R tauopathies and also include Alzheimer’s disease (AD) and chronic traumatic encephalopathy (CTE). Positron emission tomography (PET) imaging represents a pivotal instrument to guide clinicians. This systematic review aims to summarize the current and novel PET tracers. (2) Methods: Literature research was conducted on Pubmed, Scopus, Medline, Central, and the Web of Science using the query “pet ligands” and “tauopathies”. Articles published from January 2018 to 9 February, 2023, were searched. Only studies on the development of novel PET radiotracers for imaging in tauopathies or comparative studies between existing PET tracers were included. (3) Results: A total of 126 articles were found, as follows: 96 were identified from PubMed, 27 from Scopus, one on Central, two on Medline, and zero on the Web of Science. Twenty-four duplicated works were excluded, and 63 articles did not satisfy the inclusion criteria. The remaining 40 articles were included for quality assessment. (4) Conclusions: PET imaging represents a valid instrument capable of helping clinicians in diagnosis, but it is not always perfect in differential diagnosis, even if further investigations on humans for novel promising ligands are needed.https://www.mdpi.com/2075-4418/13/10/1682tauopathiesAlzheimer’s diseasePET imagingtau PETTSPOPiB |
| spellingShingle | Miriam Conte Maria Silvia De Feo Marko Magdi Abdou Sidrak Ferdinando Corica Joana Gorica Giorgia Maria Granese Luca Filippi Giuseppe De Vincentis Viviana Frantellizzi Imaging of Tauopathies with PET Ligands: State of the Art and Future Outlook Diagnostics tauopathies Alzheimer’s disease PET imaging tau PET TSPO PiB |
| title | Imaging of Tauopathies with PET Ligands: State of the Art and Future Outlook |
| title_full | Imaging of Tauopathies with PET Ligands: State of the Art and Future Outlook |
| title_fullStr | Imaging of Tauopathies with PET Ligands: State of the Art and Future Outlook |
| title_full_unstemmed | Imaging of Tauopathies with PET Ligands: State of the Art and Future Outlook |
| title_short | Imaging of Tauopathies with PET Ligands: State of the Art and Future Outlook |
| title_sort | imaging of tauopathies with pet ligands state of the art and future outlook |
| topic | tauopathies Alzheimer’s disease PET imaging tau PET TSPO PiB |
| url | https://www.mdpi.com/2075-4418/13/10/1682 |
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