Esophageal cancer and bacterial part of gut microbiota – A multidisciplinary point of view
There is an urgent need to search for new screening methods that allow early detection of esophageal cancer and thus achieve better clinical outcomes. Nowadays, it is known that the esophagus is not a sterile part of the gastrointestinal tract. It is colonized with various microorganisms therefore a...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2022.1057668/full |
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| author | Damian Muszyński Anna Kudra Bartosz Kamil Sobocki Marcin Folwarski Ermanno Vitale Veronica Filetti Wojciech Dudzic Karolina Kaźmierczak-Siedlecka Karol Połom |
| author_facet | Damian Muszyński Anna Kudra Bartosz Kamil Sobocki Marcin Folwarski Ermanno Vitale Veronica Filetti Wojciech Dudzic Karolina Kaźmierczak-Siedlecka Karol Połom |
| author_sort | Damian Muszyński |
| collection | DOAJ |
| description | There is an urgent need to search for new screening methods that allow early detection of esophageal cancer and thus achieve better clinical outcomes. Nowadays, it is known that the esophagus is not a sterile part of the gastrointestinal tract. It is colonized with various microorganisms therefore a “healthy” esophageal microbiome exists. The dysbiotic changes of esophageal microbiome can lead to the development of esophageal diseases including esophageal cancer. There is a strong consensus in the literature that the intestinal microbiome may be involved in esophageal carcinogenesis. Recently, emphasis has also been placed on the relationship between the oral microbiome and the occurrence of esophageal cancer. According to recent studies, some of the bacteria present in the oral cavity, such as Tannerella forsythia, Streptococcus anginosus, Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, and Fusobacterium nucleatum may contribute to the development of this cancer. Moreover, the oral microbiome of patients with esophageal cancer differs significantly from that of healthy individuals. This opens new insights into the search for a microbiome-associated marker for early identification of patients at high risk for developing this cancer. |
| first_indexed | 2024-04-11T08:08:57Z |
| format | Article |
| id | doaj.art-2bef26da7fcd4e0d8081bdbb07efdfe9 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-04-11T08:08:57Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-2bef26da7fcd4e0d8081bdbb07efdfe92022-12-22T04:35:24ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882022-11-011210.3389/fcimb.2022.10576681057668Esophageal cancer and bacterial part of gut microbiota – A multidisciplinary point of viewDamian Muszyński0Anna Kudra1Bartosz Kamil Sobocki2Marcin Folwarski3Ermanno Vitale4Veronica Filetti5Wojciech Dudzic6Karolina Kaźmierczak-Siedlecka7Karol Połom8Scientific Circle 4.0 associated with Department of Surgical Oncology, Medical University of Gdansk, Gdansk, PolandScientific Circle 4.0 associated with Department of Surgical Oncology, Medical University of Gdansk, Gdansk, PolandScientific Circle of Oncology and Radiotherapy, Medical University of Gdansk, Gdansk, PolandDepartment of Clinical Nutrition and Dietetics, Medical University of Gdansk, Gdansk, PolandDepartment of Clinical and Experimental Medicine, University of Catania, Occupational Medicine, Catania, ItalyDepartment of Clinical and Experimental Medicine, University of Catania, Occupational Medicine, Catania, ItalyDepartment of General and Gastrointestinal Surgery and Nutrition, Copernicus Hospital Gdansk, Gdansk, PolandDepartment of Surgical Oncology, Medical University of Gdansk, Gdansk, PolandDepartment of Surgical Oncology, Medical University of Gdansk, Gdansk, PolandThere is an urgent need to search for new screening methods that allow early detection of esophageal cancer and thus achieve better clinical outcomes. Nowadays, it is known that the esophagus is not a sterile part of the gastrointestinal tract. It is colonized with various microorganisms therefore a “healthy” esophageal microbiome exists. The dysbiotic changes of esophageal microbiome can lead to the development of esophageal diseases including esophageal cancer. There is a strong consensus in the literature that the intestinal microbiome may be involved in esophageal carcinogenesis. Recently, emphasis has also been placed on the relationship between the oral microbiome and the occurrence of esophageal cancer. According to recent studies, some of the bacteria present in the oral cavity, such as Tannerella forsythia, Streptococcus anginosus, Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, and Fusobacterium nucleatum may contribute to the development of this cancer. Moreover, the oral microbiome of patients with esophageal cancer differs significantly from that of healthy individuals. This opens new insights into the search for a microbiome-associated marker for early identification of patients at high risk for developing this cancer.https://www.frontiersin.org/articles/10.3389/fcimb.2022.1057668/fullesophageal canceresophageal microbiomegut microbiomeoral microbiome16S rRNA gene sequencing |
| spellingShingle | Damian Muszyński Anna Kudra Bartosz Kamil Sobocki Marcin Folwarski Ermanno Vitale Veronica Filetti Wojciech Dudzic Karolina Kaźmierczak-Siedlecka Karol Połom Esophageal cancer and bacterial part of gut microbiota – A multidisciplinary point of view Frontiers in Cellular and Infection Microbiology esophageal cancer esophageal microbiome gut microbiome oral microbiome 16S rRNA gene sequencing |
| title | Esophageal cancer and bacterial part of gut microbiota – A multidisciplinary point of view |
| title_full | Esophageal cancer and bacterial part of gut microbiota – A multidisciplinary point of view |
| title_fullStr | Esophageal cancer and bacterial part of gut microbiota – A multidisciplinary point of view |
| title_full_unstemmed | Esophageal cancer and bacterial part of gut microbiota – A multidisciplinary point of view |
| title_short | Esophageal cancer and bacterial part of gut microbiota – A multidisciplinary point of view |
| title_sort | esophageal cancer and bacterial part of gut microbiota a multidisciplinary point of view |
| topic | esophageal cancer esophageal microbiome gut microbiome oral microbiome 16S rRNA gene sequencing |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2022.1057668/full |
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