Personalized Management of Patients with Chronic Rhinosinusitis with Nasal Polyps in Clinical Practice: A Multidisciplinary Consensus Statement

Chronic rhinosinusitis (CRS) is a sino-nasal chronic inflammatory disease, occurring in 5–15% of the general population. CRS with nasal polyps (CRSwNP) is present in up to 30% of the CRS population. One-third of CRSwNP patients suffer from disease that is uncontrolled by current standards of care. B...

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Main Authors: Eugenio De Corso, Maria Beatrice Bilò, Andrea Matucci, Veronica Seccia, Fulvio Braido, Matteo Gelardi, Enrico Heffler, Manuela Latorre, Luca Malvezzi, Girolamo Pelaia, Gianenrico Senna, Paolo Castelnuovo, Giorgio Walter Canonica
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Journal of Personalized Medicine
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Online Access:https://www.mdpi.com/2075-4426/12/5/846
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author Eugenio De Corso
Maria Beatrice Bilò
Andrea Matucci
Veronica Seccia
Fulvio Braido
Matteo Gelardi
Enrico Heffler
Manuela Latorre
Luca Malvezzi
Girolamo Pelaia
Gianenrico Senna
Paolo Castelnuovo
Giorgio Walter Canonica
author_facet Eugenio De Corso
Maria Beatrice Bilò
Andrea Matucci
Veronica Seccia
Fulvio Braido
Matteo Gelardi
Enrico Heffler
Manuela Latorre
Luca Malvezzi
Girolamo Pelaia
Gianenrico Senna
Paolo Castelnuovo
Giorgio Walter Canonica
author_sort Eugenio De Corso
collection DOAJ
description Chronic rhinosinusitis (CRS) is a sino-nasal chronic inflammatory disease, occurring in 5–15% of the general population. CRS with nasal polyps (CRSwNP) is present in up to 30% of the CRS population. One-third of CRSwNP patients suffer from disease that is uncontrolled by current standards of care. Biologics are an emerging treatment option for patients with severe uncontrolled CRSwNP, but their positioning in the treatment algorithm is under discussion. Effective endotyping of CRSwNP patients who could benefit from biologics treatment is required, as suggested by international guidelines. Other issues affecting management include comorbidities, such as allergy, non-steroidal anti-inflammatory drug–exacerbated respiratory disease, and asthma. Therefore, the choice of treatment in CRSwNP patients depends on many factors. A multidisciplinary approach may improve CRSwNP management in patients with comorbidities, but currently there is no shared management model. We summarize the outcomes of a Delphi process involving a multidisciplinary panel of otolaryngologists, pulmonologists, and allergist-immunologists involved in the management of CRSwNP, who attempted to reach consensus on key statements relating to the diagnosis, endotyping, classification and management (including the place of biologics) of CRSwNP patients.
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spelling doaj.art-2bf0d60e453d4473a21c147c7d5e34d42023-11-23T11:45:45ZengMDPI AGJournal of Personalized Medicine2075-44262022-05-0112584610.3390/jpm12050846Personalized Management of Patients with Chronic Rhinosinusitis with Nasal Polyps in Clinical Practice: A Multidisciplinary Consensus StatementEugenio De Corso0Maria Beatrice Bilò1Andrea Matucci2Veronica Seccia3Fulvio Braido4Matteo Gelardi5Enrico Heffler6Manuela Latorre7Luca Malvezzi8Girolamo Pelaia9Gianenrico Senna10Paolo Castelnuovo11Giorgio Walter Canonica12A. Gemelli University Hospital Foundation IRCCS, Otorhinolaryngology, Catholic University of the Sacred Heart, 00168 Rome, ItalyDepartment of Clinical and Molecular Sciences, Università Politecnica delle Marche, 60131 Ancona, ItalyImmunoallergology Unit, University Hospital Careggi, 50134 Florence, ItalyOtolaryngology Audiology and Phoniatric Operative Unit, Department of Surgical, Medical, Molecular Pathology and Critical Care Medicine, Azienda Ospedaliero Universitaria Pisana, University of Pisa, 56124 Pisa, ItalyRespiratory Unit for Continuity of Care, IRCCS, Ospedale Policlinico San Martino, 16132 Genoa, ItalyDepartment of Otolaryngology, University Hospital of Foggia, 71100 Foggia, ItalyPersonalized Medicine, Asthma and Allergy-IRCCS Humanitas Research Hospital, 20122 Milan, ItalyDepartment of Medical Specialties, Pulmonary Unit, Hospital of Massa, 54100 Massa, ItalyDepartment of Biomedical Sciences, Humanitas University, 20072 Milan, ItalyDepartment of Health Sciences, University Magna Graecia, 88100 Catanzaro, ItalyDepartment of Allergology, Azienda Ospedaliera Universitaria Integrata Verona, 37126 Verona, ItalyDepartment of Biotechnology and Life Sciences, Università degli Studi dell’Insubria, 21100 Varese, ItalyPersonalized Medicine, Asthma and Allergy-IRCCS Humanitas Research Hospital, 20122 Milan, ItalyChronic rhinosinusitis (CRS) is a sino-nasal chronic inflammatory disease, occurring in 5–15% of the general population. CRS with nasal polyps (CRSwNP) is present in up to 30% of the CRS population. One-third of CRSwNP patients suffer from disease that is uncontrolled by current standards of care. Biologics are an emerging treatment option for patients with severe uncontrolled CRSwNP, but their positioning in the treatment algorithm is under discussion. Effective endotyping of CRSwNP patients who could benefit from biologics treatment is required, as suggested by international guidelines. Other issues affecting management include comorbidities, such as allergy, non-steroidal anti-inflammatory drug–exacerbated respiratory disease, and asthma. Therefore, the choice of treatment in CRSwNP patients depends on many factors. A multidisciplinary approach may improve CRSwNP management in patients with comorbidities, but currently there is no shared management model. We summarize the outcomes of a Delphi process involving a multidisciplinary panel of otolaryngologists, pulmonologists, and allergist-immunologists involved in the management of CRSwNP, who attempted to reach consensus on key statements relating to the diagnosis, endotyping, classification and management (including the place of biologics) of CRSwNP patients.https://www.mdpi.com/2075-4426/12/5/846nasal polypschronic rhinosinusitisbiologicsallergyasthmanon-steroidal anti-inflammatory drugs
spellingShingle Eugenio De Corso
Maria Beatrice Bilò
Andrea Matucci
Veronica Seccia
Fulvio Braido
Matteo Gelardi
Enrico Heffler
Manuela Latorre
Luca Malvezzi
Girolamo Pelaia
Gianenrico Senna
Paolo Castelnuovo
Giorgio Walter Canonica
Personalized Management of Patients with Chronic Rhinosinusitis with Nasal Polyps in Clinical Practice: A Multidisciplinary Consensus Statement
Journal of Personalized Medicine
nasal polyps
chronic rhinosinusitis
biologics
allergy
asthma
non-steroidal anti-inflammatory drugs
title Personalized Management of Patients with Chronic Rhinosinusitis with Nasal Polyps in Clinical Practice: A Multidisciplinary Consensus Statement
title_full Personalized Management of Patients with Chronic Rhinosinusitis with Nasal Polyps in Clinical Practice: A Multidisciplinary Consensus Statement
title_fullStr Personalized Management of Patients with Chronic Rhinosinusitis with Nasal Polyps in Clinical Practice: A Multidisciplinary Consensus Statement
title_full_unstemmed Personalized Management of Patients with Chronic Rhinosinusitis with Nasal Polyps in Clinical Practice: A Multidisciplinary Consensus Statement
title_short Personalized Management of Patients with Chronic Rhinosinusitis with Nasal Polyps in Clinical Practice: A Multidisciplinary Consensus Statement
title_sort personalized management of patients with chronic rhinosinusitis with nasal polyps in clinical practice a multidisciplinary consensus statement
topic nasal polyps
chronic rhinosinusitis
biologics
allergy
asthma
non-steroidal anti-inflammatory drugs
url https://www.mdpi.com/2075-4426/12/5/846
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