Early p38 Activation Regulated by MKP-1 Is Determinant for High Levels of IL-10 Expression Through TLR2 Activation

Early p38 Activation Regulated by MKP-1 Is Determinant for High Levels of IL-10 Expression Through TLR2 Activation

Toll-like receptors (TLRs) play a crucial role in the recognition of pathogen-derived components as a first line of defense against infections. It has been suggested that depending on the nature of the pathogens, TLRs activation induce a distinct cytokine profile that may contribute to the polarizat...

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Bibliographic Details
Main Authors: Sara Francisco, Alicia Arranz, Javier Merino, Carmen Punzón, Rosario Perona, Manuel Fresno
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
macrophages
innate immunity
toll-like receptors
MAPK signaling
cytokines
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.660065/full

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