Non-B, Non-C Hepatocellular Carcinoma in an HBV- and HCV-Endemic Area: A Community-Based Prospective Longitudinal Study
A large community cohort of adults who participated in a health screening program from 2003 to 2013 were prospectively analyzed for the risk factors of non-B, non-C (NBNC) hepatocellular carcinoma (HCC). The serostatus of hepatitis B and C of 52,642 participants was linked to the mortality and cance...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/14/5/984 |
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| author | Te-Sheng Chang Nien-Tzu Hsu Shu-Chuan Chen I-Lin Hsu Mei-Hsuan Lee Sheng-Nan Lu |
| author_facet | Te-Sheng Chang Nien-Tzu Hsu Shu-Chuan Chen I-Lin Hsu Mei-Hsuan Lee Sheng-Nan Lu |
| author_sort | Te-Sheng Chang |
| collection | DOAJ |
| description | A large community cohort of adults who participated in a health screening program from 2003 to 2013 were prospectively analyzed for the risk factors of non-B, non-C (NBNC) hepatocellular carcinoma (HCC). The serostatus of hepatitis B and C of 52,642 participants was linked to the mortality and cancer registration data of the Health and Welfare Data Science Center, Ministry of Health and Welfare, Taiwan. During a median follow-up of 6 years, 35 of the 43,545 participants who were negative for both HBsAg and anti-HCV antibody developed HCC. Multivariate Cox regression analysis revealed that old age (hazard ratio, 95% CI: 1.058, 1.019–1.098, <i>p</i> = 0.003); male sex (2.446, 1.200–4.985, <i>p</i> = 0.014); high aspartate aminotransferase levels (6.816, 2.945–15.779, <i>p</i> < 0.001); fibrosis index based on four factor score (1.262, 1.154–1.381, <i>p</i> < 0.001); blood sugar (1.009, 1.002–1.015, <i>p</i> = 0.006); and alpha-fetoprotein ≥15 ng/mL (143.938, 43.094–480.760, <i>p</i> < 0.001) were independent risk factors for HCC. By contrast, triglyceride >150 mg/dL was associated with a decreased risk of HCC (0.216, 0.074–0.625, <i>p</i> = 0.005). This prospective community-based study provided insights into the potential HCC risk factors which may shed some light in HCC prevention and screening. |
| first_indexed | 2024-03-10T01:37:12Z |
| format | Article |
| id | doaj.art-2bf60ff989434b40b97d1735a441380d |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T01:37:12Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-2bf60ff989434b40b97d1735a441380d2023-11-23T13:31:21ZengMDPI AGViruses1999-49152022-05-0114598410.3390/v14050984Non-B, Non-C Hepatocellular Carcinoma in an HBV- and HCV-Endemic Area: A Community-Based Prospective Longitudinal StudyTe-Sheng Chang0Nien-Tzu Hsu1Shu-Chuan Chen2I-Lin Hsu3Mei-Hsuan Lee4Sheng-Nan Lu5Department of Gastroenterology and Hepatology, Division of Internal Medicine, Chang Gung Memorial Hospital, Chiayi 613016, TaiwanBiostatistics Center of Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833253, TaiwanPublic Health Bureau, Tainan City Government, Tainan 701017, TaiwanPublic Health Bureau, Tainan City Government, Tainan 701017, TaiwanSchool of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, TaiwanCollege of Medicine, Chang Gung University, Taoyuan 333323, TaiwanA large community cohort of adults who participated in a health screening program from 2003 to 2013 were prospectively analyzed for the risk factors of non-B, non-C (NBNC) hepatocellular carcinoma (HCC). The serostatus of hepatitis B and C of 52,642 participants was linked to the mortality and cancer registration data of the Health and Welfare Data Science Center, Ministry of Health and Welfare, Taiwan. During a median follow-up of 6 years, 35 of the 43,545 participants who were negative for both HBsAg and anti-HCV antibody developed HCC. Multivariate Cox regression analysis revealed that old age (hazard ratio, 95% CI: 1.058, 1.019–1.098, <i>p</i> = 0.003); male sex (2.446, 1.200–4.985, <i>p</i> = 0.014); high aspartate aminotransferase levels (6.816, 2.945–15.779, <i>p</i> < 0.001); fibrosis index based on four factor score (1.262, 1.154–1.381, <i>p</i> < 0.001); blood sugar (1.009, 1.002–1.015, <i>p</i> = 0.006); and alpha-fetoprotein ≥15 ng/mL (143.938, 43.094–480.760, <i>p</i> < 0.001) were independent risk factors for HCC. By contrast, triglyceride >150 mg/dL was associated with a decreased risk of HCC (0.216, 0.074–0.625, <i>p</i> = 0.005). This prospective community-based study provided insights into the potential HCC risk factors which may shed some light in HCC prevention and screening.https://www.mdpi.com/1999-4915/14/5/984non-B, non-Chepatocellular carcinomarisk factorprospective study |
| spellingShingle | Te-Sheng Chang Nien-Tzu Hsu Shu-Chuan Chen I-Lin Hsu Mei-Hsuan Lee Sheng-Nan Lu Non-B, Non-C Hepatocellular Carcinoma in an HBV- and HCV-Endemic Area: A Community-Based Prospective Longitudinal Study Viruses non-B, non-C hepatocellular carcinoma risk factor prospective study |
| title | Non-B, Non-C Hepatocellular Carcinoma in an HBV- and HCV-Endemic Area: A Community-Based Prospective Longitudinal Study |
| title_full | Non-B, Non-C Hepatocellular Carcinoma in an HBV- and HCV-Endemic Area: A Community-Based Prospective Longitudinal Study |
| title_fullStr | Non-B, Non-C Hepatocellular Carcinoma in an HBV- and HCV-Endemic Area: A Community-Based Prospective Longitudinal Study |
| title_full_unstemmed | Non-B, Non-C Hepatocellular Carcinoma in an HBV- and HCV-Endemic Area: A Community-Based Prospective Longitudinal Study |
| title_short | Non-B, Non-C Hepatocellular Carcinoma in an HBV- and HCV-Endemic Area: A Community-Based Prospective Longitudinal Study |
| title_sort | non b non c hepatocellular carcinoma in an hbv and hcv endemic area a community based prospective longitudinal study |
| topic | non-B, non-C hepatocellular carcinoma risk factor prospective study |
| url | https://www.mdpi.com/1999-4915/14/5/984 |
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