Embelin and Its Derivatives: Design, Synthesis, and Potential Delivery Systems for Cancer Therapy
Embelin is a naturally occurring benzoquinone that inhibits the growth of cancer cells, making it a potent anticancer drug. However, the low water solubility of embelin restricts its clinical applicability. This review provides a concise summary and in-depth analysis of the published literature on t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/15/9/1131 |
| _version_ | 1827657878427664384 |
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| author | Michael Danquah |
| author_facet | Michael Danquah |
| author_sort | Michael Danquah |
| collection | DOAJ |
| description | Embelin is a naturally occurring benzoquinone that inhibits the growth of cancer cells, making it a potent anticancer drug. However, the low water solubility of embelin restricts its clinical applicability. This review provides a concise summary and in-depth analysis of the published literature on the design and synthesis of embelin derivatives possessing increased aqueous solubility and superior therapeutic efficacy. In addition, the potential of drug delivery systems to improve the anticancer capabilities of embelin and its derivatives is discussed. |
| first_indexed | 2024-03-09T22:51:06Z |
| format | Article |
| id | doaj.art-2bf6d9f6073d405db29b1b083b73a2d3 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-09T22:51:06Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-2bf6d9f6073d405db29b1b083b73a2d32023-11-23T18:19:13ZengMDPI AGPharmaceuticals1424-82472022-09-01159113110.3390/ph15091131Embelin and Its Derivatives: Design, Synthesis, and Potential Delivery Systems for Cancer TherapyMichael Danquah0Department of Pharmaceutical Sciences, Chicago State University, 9501 South King Drive, Chicago, IL 60628, USAEmbelin is a naturally occurring benzoquinone that inhibits the growth of cancer cells, making it a potent anticancer drug. However, the low water solubility of embelin restricts its clinical applicability. This review provides a concise summary and in-depth analysis of the published literature on the design and synthesis of embelin derivatives possessing increased aqueous solubility and superior therapeutic efficacy. In addition, the potential of drug delivery systems to improve the anticancer capabilities of embelin and its derivatives is discussed.https://www.mdpi.com/1424-8247/15/9/1131embelinembelin derivativesXIAP inhibitorXIAPdrug deliverycancer therapy |
| spellingShingle | Michael Danquah Embelin and Its Derivatives: Design, Synthesis, and Potential Delivery Systems for Cancer Therapy Pharmaceuticals embelin embelin derivatives XIAP inhibitor XIAP drug delivery cancer therapy |
| title | Embelin and Its Derivatives: Design, Synthesis, and Potential Delivery Systems for Cancer Therapy |
| title_full | Embelin and Its Derivatives: Design, Synthesis, and Potential Delivery Systems for Cancer Therapy |
| title_fullStr | Embelin and Its Derivatives: Design, Synthesis, and Potential Delivery Systems for Cancer Therapy |
| title_full_unstemmed | Embelin and Its Derivatives: Design, Synthesis, and Potential Delivery Systems for Cancer Therapy |
| title_short | Embelin and Its Derivatives: Design, Synthesis, and Potential Delivery Systems for Cancer Therapy |
| title_sort | embelin and its derivatives design synthesis and potential delivery systems for cancer therapy |
| topic | embelin embelin derivatives XIAP inhibitor XIAP drug delivery cancer therapy |
| url | https://www.mdpi.com/1424-8247/15/9/1131 |
| work_keys_str_mv | AT michaeldanquah embelinanditsderivativesdesignsynthesisandpotentialdeliverysystemsforcancertherapy |