Naturally Occurring Isocoumarins Derivatives from Endophytic Fungi: Sources, Isolation, Structural Characterization, Biosynthesis, and Biological Activities
Recently, the metabolites separated from endophytes have attracted significant attention, as many of them have a unique structure and appealing pharmacological and biological potentials. Isocoumarins represent one of the most interesting classes of metabolites, which are coumarins isomers with a rev...
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MDPI AG
2020-01-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/2/395 |
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| author | Ahmad Omar Noor Diena Mohammedallam Almasri Alaa Abdullah Bagalagel Hossam Mohamed Abdallah Shaimaa Gamal Abdallah Mohamed Gamal Abdallah Mohamed Sabrin Ragab Mohamed Ibrahim |
| author_facet | Ahmad Omar Noor Diena Mohammedallam Almasri Alaa Abdullah Bagalagel Hossam Mohamed Abdallah Shaimaa Gamal Abdallah Mohamed Gamal Abdallah Mohamed Sabrin Ragab Mohamed Ibrahim |
| author_sort | Ahmad Omar Noor |
| collection | DOAJ |
| description | Recently, the metabolites separated from endophytes have attracted significant attention, as many of them have a unique structure and appealing pharmacological and biological potentials. Isocoumarins represent one of the most interesting classes of metabolites, which are coumarins isomers with a reversed lactone moiety. They are produced by plants, microbes, marine organisms, bacteria, insects, liverworts, and fungi and possessed a wide array of bioactivities. This review gives an overview of isocoumarins derivatives from endophytic fungi and their source, isolation, structural characterization, biosynthesis, and bioactivities, concentrating on the period from 2000 to 2019. Overall, 307 metabolites and more than 120 references are conferred. This is the first review on these multi-facetted metabolites from endophytic fungi. |
| first_indexed | 2024-12-13T01:02:40Z |
| format | Article |
| id | doaj.art-2bf8b38ad30e4acfb52cb3771f5f0a99 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-13T01:02:40Z |
| publishDate | 2020-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-2bf8b38ad30e4acfb52cb3771f5f0a992022-12-22T00:04:38ZengMDPI AGMolecules1420-30492020-01-0125239510.3390/molecules25020395molecules25020395Naturally Occurring Isocoumarins Derivatives from Endophytic Fungi: Sources, Isolation, Structural Characterization, Biosynthesis, and Biological ActivitiesAhmad Omar Noor0Diena Mohammedallam Almasri1Alaa Abdullah Bagalagel2Hossam Mohamed Abdallah3Shaimaa Gamal Abdallah Mohamed4Gamal Abdallah Mohamed5Sabrin Ragab Mohamed Ibrahim6Pharmacy Practice Department, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi ArabiaPharmacy Practice Department, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi ArabiaPharmacy Practice Department, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi ArabiaDepartment of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi ArabiaFaculty of Dentistry, British University, El Sherouk City, Suez Desert Road, Cairo 11837, EgyptDepartment of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi ArabiaDepartment of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University, Al Madinah Al-Munawwarah 30078, Saudi ArabiaRecently, the metabolites separated from endophytes have attracted significant attention, as many of them have a unique structure and appealing pharmacological and biological potentials. Isocoumarins represent one of the most interesting classes of metabolites, which are coumarins isomers with a reversed lactone moiety. They are produced by plants, microbes, marine organisms, bacteria, insects, liverworts, and fungi and possessed a wide array of bioactivities. This review gives an overview of isocoumarins derivatives from endophytic fungi and their source, isolation, structural characterization, biosynthesis, and bioactivities, concentrating on the period from 2000 to 2019. Overall, 307 metabolites and more than 120 references are conferred. This is the first review on these multi-facetted metabolites from endophytic fungi.https://www.mdpi.com/1420-3049/25/2/395endophytesisocoumarinsdihydroisocoumarinsbiosynthesisbiological activities |
| spellingShingle | Ahmad Omar Noor Diena Mohammedallam Almasri Alaa Abdullah Bagalagel Hossam Mohamed Abdallah Shaimaa Gamal Abdallah Mohamed Gamal Abdallah Mohamed Sabrin Ragab Mohamed Ibrahim Naturally Occurring Isocoumarins Derivatives from Endophytic Fungi: Sources, Isolation, Structural Characterization, Biosynthesis, and Biological Activities Molecules endophytes isocoumarins dihydroisocoumarins biosynthesis biological activities |
| title | Naturally Occurring Isocoumarins Derivatives from Endophytic Fungi: Sources, Isolation, Structural Characterization, Biosynthesis, and Biological Activities |
| title_full | Naturally Occurring Isocoumarins Derivatives from Endophytic Fungi: Sources, Isolation, Structural Characterization, Biosynthesis, and Biological Activities |
| title_fullStr | Naturally Occurring Isocoumarins Derivatives from Endophytic Fungi: Sources, Isolation, Structural Characterization, Biosynthesis, and Biological Activities |
| title_full_unstemmed | Naturally Occurring Isocoumarins Derivatives from Endophytic Fungi: Sources, Isolation, Structural Characterization, Biosynthesis, and Biological Activities |
| title_short | Naturally Occurring Isocoumarins Derivatives from Endophytic Fungi: Sources, Isolation, Structural Characterization, Biosynthesis, and Biological Activities |
| title_sort | naturally occurring isocoumarins derivatives from endophytic fungi sources isolation structural characterization biosynthesis and biological activities |
| topic | endophytes isocoumarins dihydroisocoumarins biosynthesis biological activities |
| url | https://www.mdpi.com/1420-3049/25/2/395 |
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