Resolvin D2 and Resolvin D1 Differentially Activate Protein Kinases to Counter-Regulate Histamine-Induced [Ca<sup>2+</sup>]<sub>i</sub> Increase and Mucin Secretion in Conjunctival Goblet Cells

Resolvin D2 and Resolvin D1 Differentially Activate Protein Kinases to Counter-Regulate Histamine-Induced [Ca<sup>2+</sup>]<sub>i</sub> Increase and Mucin Secretion in Conjunctival Goblet Cells

Resolvin (Rv) D2 and RvD1 are biosynthesized from docosahexaenoic acid (DHA) and promote resolution of inflammation in multiple organs and tissues, including the conjunctiva. Histamine is a mediator produced by mast cells in the conjunctiva during the allergic response. We determined the interaction...

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Bibliographic Details
Main Authors: Menglu Yang, Nora Botten, Robin Hodges, Jeffrey Bair, Tor P. Utheim, Charles N. Serhan, Darlene A. Dartt
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
ocular allergy
conjunctivitis
histamine
SPMs
RvD1
RvD2
Online Access:https://www.mdpi.com/1422-0067/23/1/141

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