The Phenolics from the Roots of Livistona chinensis Show Antioxidative and Obsteoblast Differentiation Promoting Activity
This study investigated the antioxidative and obsteoblast differentiation promoting activity of the phenolics isolated from the 70% ethanol extract of the roots of Livistona chinensis. Two new phenolics, (2R,3R)-3,5,6,7,3',4'-hexahydroxyflavane (1), and phenanthrene-2,4,9-triol (2), togeth...
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MDPI AG
2013-12-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/19/1/263 |
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| author | Xiaobin Zeng Jun Tian Liao Cui Yang Wang Yanjie Su Xin Zhou Xiangjiu He |
| author_facet | Xiaobin Zeng Jun Tian Liao Cui Yang Wang Yanjie Su Xin Zhou Xiangjiu He |
| author_sort | Xiaobin Zeng |
| collection | DOAJ |
| description | This study investigated the antioxidative and obsteoblast differentiation promoting activity of the phenolics isolated from the 70% ethanol extract of the roots of Livistona chinensis. Two new phenolics, (2R,3R)-3,5,6,7,3',4'-hexahydroxyflavane (1), and phenanthrene-2,4,9-triol (2), together with six known phenolics 3–8, were isolated and identified on the basis of extensive spectroscopic analysis. The antioxidative and obsteoblast differentiation promoting abilities of the compounds 1–3, 7–8 were tested, the phenolics 1–3, 7 showed effects on proliferation of osteoblastic cells and antioxidative activity of 3.125–50 µg/mL. In addition, the phenolics 1–3 observably increased alkaline phosphatase activity, osteocalcin content and hydroxyproline content in osteoblastic cells. Phenolic 1 at 12.5 µg/mL concentration significantly increased the area of nodules by about 9.35-fold. The antioxidative activity results indicated that the anti-osteoporosis effects of these phenolics may be linked to a reduction of oxidative stress. The observed effects of these phenolics on bone formation by rat osteoblastic cells suggest that these phenolics may have beneficial effects on bone health. |
| first_indexed | 2024-04-13T19:53:33Z |
| format | Article |
| id | doaj.art-2bfb425a81bd4d4799fe04e532c529bc |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-13T19:53:33Z |
| publishDate | 2013-12-01 |
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| series | Molecules |
| spelling | doaj.art-2bfb425a81bd4d4799fe04e532c529bc2022-12-22T02:32:25ZengMDPI AGMolecules1420-30492013-12-0119126327810.3390/molecules19010263molecules19010263The Phenolics from the Roots of Livistona chinensis Show Antioxidative and Obsteoblast Differentiation Promoting ActivityXiaobin Zeng0Jun Tian1Liao Cui2Yang Wang3Yanjie Su4Xin Zhou5Xiangjiu He6Guangdong Key Laboratory for Research and Development of Natural Drugs, Department of Pharmacology, Guangdong Medical College, Zhanjiang 524023, Guangdong, ChinaCollege of Life Science, Jiangsu Normal University, Xuzhou 221116, Jiangsu, ChinaGuangdong Key Laboratory for Research and Development of Natural Drugs, Department of Pharmacology, Guangdong Medical College, Zhanjiang 524023, Guangdong, ChinaShenzhen Xinpeng Shengwu Gongcheng Co. LTD, Shenzhen 518055, Guangdong, ChinaGuangdong Key Laboratory for Research and Development of Natural Drugs, Department of Pharmacology, Guangdong Medical College, Zhanjiang 524023, Guangdong, ChinaGuangdong Key Laboratory for Research and Development of Natural Drugs, Department of Pharmacology, Guangdong Medical College, Zhanjiang 524023, Guangdong, ChinaSchool of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, Hubei, ChinaThis study investigated the antioxidative and obsteoblast differentiation promoting activity of the phenolics isolated from the 70% ethanol extract of the roots of Livistona chinensis. Two new phenolics, (2R,3R)-3,5,6,7,3',4'-hexahydroxyflavane (1), and phenanthrene-2,4,9-triol (2), together with six known phenolics 3–8, were isolated and identified on the basis of extensive spectroscopic analysis. The antioxidative and obsteoblast differentiation promoting abilities of the compounds 1–3, 7–8 were tested, the phenolics 1–3, 7 showed effects on proliferation of osteoblastic cells and antioxidative activity of 3.125–50 µg/mL. In addition, the phenolics 1–3 observably increased alkaline phosphatase activity, osteocalcin content and hydroxyproline content in osteoblastic cells. Phenolic 1 at 12.5 µg/mL concentration significantly increased the area of nodules by about 9.35-fold. The antioxidative activity results indicated that the anti-osteoporosis effects of these phenolics may be linked to a reduction of oxidative stress. The observed effects of these phenolics on bone formation by rat osteoblastic cells suggest that these phenolics may have beneficial effects on bone health.http://www.mdpi.com/1420-3049/19/1/263phenolicflavaneLivistona chinensisosteoporosisoxidative stress |
| spellingShingle | Xiaobin Zeng Jun Tian Liao Cui Yang Wang Yanjie Su Xin Zhou Xiangjiu He The Phenolics from the Roots of Livistona chinensis Show Antioxidative and Obsteoblast Differentiation Promoting Activity Molecules phenolic flavane Livistona chinensis osteoporosis oxidative stress |
| title | The Phenolics from the Roots of Livistona chinensis Show Antioxidative and Obsteoblast Differentiation Promoting Activity |
| title_full | The Phenolics from the Roots of Livistona chinensis Show Antioxidative and Obsteoblast Differentiation Promoting Activity |
| title_fullStr | The Phenolics from the Roots of Livistona chinensis Show Antioxidative and Obsteoblast Differentiation Promoting Activity |
| title_full_unstemmed | The Phenolics from the Roots of Livistona chinensis Show Antioxidative and Obsteoblast Differentiation Promoting Activity |
| title_short | The Phenolics from the Roots of Livistona chinensis Show Antioxidative and Obsteoblast Differentiation Promoting Activity |
| title_sort | phenolics from the roots of livistona chinensis show antioxidative and obsteoblast differentiation promoting activity |
| topic | phenolic flavane Livistona chinensis osteoporosis oxidative stress |
| url | http://www.mdpi.com/1420-3049/19/1/263 |
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