Interleukin 1 receptor antagonist relation to cardiovascular disease risk in patients with rheumatoid arthritis
Abstract Interleukin (IL) 1, and its family member, IL-1 receptor antagonist (IL-1ra), are involved in the pathogenesis and inflammation perpetuation of patients with rheumatoid arthritis (RA). Besides, IL-1 has been linked to an increased risk and greater severity of cardiovascular (CV) disease. We...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-08-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-18128-5 |
| _version_ | 1818084432727244800 |
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| author | Cristina Almeida-Santiago Juan Carlos Quevedo-Abeledo Vanesa Hernández-Hernández Antonia de Vera-González Alejandra Gonzalez-Delgado Miguel Ángel González-Gay Iván Ferraz-Amaro |
| author_facet | Cristina Almeida-Santiago Juan Carlos Quevedo-Abeledo Vanesa Hernández-Hernández Antonia de Vera-González Alejandra Gonzalez-Delgado Miguel Ángel González-Gay Iván Ferraz-Amaro |
| author_sort | Cristina Almeida-Santiago |
| collection | DOAJ |
| description | Abstract Interleukin (IL) 1, and its family member, IL-1 receptor antagonist (IL-1ra), are involved in the pathogenesis and inflammation perpetuation of patients with rheumatoid arthritis (RA). Besides, IL-1 has been linked to an increased risk and greater severity of cardiovascular (CV) disease. We aimed to study if IL-1ra is related to the CV manifestations—including lipid pattern and insulin resistance or subclinical atherosclerosis—that accompanies the disease in a large series of patients with RA. Cross-sectional study that encompassed 430 patients with RA. Serum IL-1ra levels were assessed. A multivariable analysis was performed to analyze the relation of IL-1ra to subclinical carotid atherosclerosis, and to traditional CV factors including a complete lipid molecules profile and insulin resistance or beta cell function indices. Body mass index, abdominal circumference, and the presence of obesity were significantly and positively associated with circulating IL-1ra. Similarly, erythrocyte sedimentation rate, and disease activity scores were significantly related to higher IL-1ra serum levels after adjustment for confounders. Neither carotid intima-media thickness nor the presence of carotid plaque were associated with serum levels of IL-1ra. However, after multivariable analysis circulating IL-1ra was independently and positively associated with higher serum levels of total cholesterol, triglycerides, and apolipoproteins B and C-III. Similarly, IL-1ra was related to higher levels of beta-cell function in the univariable analysis, although, in this case, significance was lost after adjustment. Among patients with RA, IL-1ra is associated with both disease activity and several traditional CV risk factors such as obesity and the presence of higher lipid levels. Our findings suggest that IL-1ra can represent a link between the inflammation and the CV disease risk that are present in patients with RA. |
| first_indexed | 2024-12-10T19:53:48Z |
| format | Article |
| id | doaj.art-2bffb33c9028410988fe170be1afbf9d |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-10T19:53:48Z |
| publishDate | 2022-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-2bffb33c9028410988fe170be1afbf9d2022-12-22T01:35:42ZengNature PortfolioScientific Reports2045-23222022-08-011211810.1038/s41598-022-18128-5Interleukin 1 receptor antagonist relation to cardiovascular disease risk in patients with rheumatoid arthritisCristina Almeida-Santiago0Juan Carlos Quevedo-Abeledo1Vanesa Hernández-Hernández2Antonia de Vera-González3Alejandra Gonzalez-Delgado4Miguel Ángel González-Gay5Iván Ferraz-Amaro6Servicio de Reumatología, Hospital Universitario Dr. NegrínServicio de Reumatología, Hospital Universitario Dr. NegrínServicio de Reumatología, Hospital Universitario de CanariasServicio de Laboratorio Central, Hospital Universitario de CanariasServicio de Laboratorio Central, Hospital Universitario de CanariasDivision of Rheumatology, Hospital Universitario Marqués de ValdecillaServicio de Reumatología, Hospital Universitario de CanariasAbstract Interleukin (IL) 1, and its family member, IL-1 receptor antagonist (IL-1ra), are involved in the pathogenesis and inflammation perpetuation of patients with rheumatoid arthritis (RA). Besides, IL-1 has been linked to an increased risk and greater severity of cardiovascular (CV) disease. We aimed to study if IL-1ra is related to the CV manifestations—including lipid pattern and insulin resistance or subclinical atherosclerosis—that accompanies the disease in a large series of patients with RA. Cross-sectional study that encompassed 430 patients with RA. Serum IL-1ra levels were assessed. A multivariable analysis was performed to analyze the relation of IL-1ra to subclinical carotid atherosclerosis, and to traditional CV factors including a complete lipid molecules profile and insulin resistance or beta cell function indices. Body mass index, abdominal circumference, and the presence of obesity were significantly and positively associated with circulating IL-1ra. Similarly, erythrocyte sedimentation rate, and disease activity scores were significantly related to higher IL-1ra serum levels after adjustment for confounders. Neither carotid intima-media thickness nor the presence of carotid plaque were associated with serum levels of IL-1ra. However, after multivariable analysis circulating IL-1ra was independently and positively associated with higher serum levels of total cholesterol, triglycerides, and apolipoproteins B and C-III. Similarly, IL-1ra was related to higher levels of beta-cell function in the univariable analysis, although, in this case, significance was lost after adjustment. Among patients with RA, IL-1ra is associated with both disease activity and several traditional CV risk factors such as obesity and the presence of higher lipid levels. Our findings suggest that IL-1ra can represent a link between the inflammation and the CV disease risk that are present in patients with RA.https://doi.org/10.1038/s41598-022-18128-5 |
| spellingShingle | Cristina Almeida-Santiago Juan Carlos Quevedo-Abeledo Vanesa Hernández-Hernández Antonia de Vera-González Alejandra Gonzalez-Delgado Miguel Ángel González-Gay Iván Ferraz-Amaro Interleukin 1 receptor antagonist relation to cardiovascular disease risk in patients with rheumatoid arthritis Scientific Reports |
| title | Interleukin 1 receptor antagonist relation to cardiovascular disease risk in patients with rheumatoid arthritis |
| title_full | Interleukin 1 receptor antagonist relation to cardiovascular disease risk in patients with rheumatoid arthritis |
| title_fullStr | Interleukin 1 receptor antagonist relation to cardiovascular disease risk in patients with rheumatoid arthritis |
| title_full_unstemmed | Interleukin 1 receptor antagonist relation to cardiovascular disease risk in patients with rheumatoid arthritis |
| title_short | Interleukin 1 receptor antagonist relation to cardiovascular disease risk in patients with rheumatoid arthritis |
| title_sort | interleukin 1 receptor antagonist relation to cardiovascular disease risk in patients with rheumatoid arthritis |
| url | https://doi.org/10.1038/s41598-022-18128-5 |
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