Cytoreductive prostatectomy improves survival outcomes in patients with oligometastases: a systematic meta-analysis
Abstract Background Whether cytoreductive prostatectomy (CRP) should be performed in patients with oligometastatic prostate cancer (OPC) remains controversial. The goal of this systematic meta-analysis was to assess the efficacy of CRP as a treatment for OPC. Methods This systematic review and meta-...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-08-01
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| Series: | World Journal of Surgical Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12957-022-02715-x |
| _version_ | 1811320808154333184 |
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| author | Yifeng Mao Mingqiu Hu Gaowei Yang Erke Gao Wangwang Xu |
| author_facet | Yifeng Mao Mingqiu Hu Gaowei Yang Erke Gao Wangwang Xu |
| author_sort | Yifeng Mao |
| collection | DOAJ |
| description | Abstract Background Whether cytoreductive prostatectomy (CRP) should be performed in patients with oligometastatic prostate cancer (OPC) remains controversial. The goal of this systematic meta-analysis was to assess the efficacy of CRP as a treatment for OPC. Methods This systematic review and meta-analysis was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis statement. Data sources included publications in the PubMed, Embase, the Cochrane Library, EBSCO, and Web of Science (SCI) databases as of May 2022. Eligible articles included prospective studies comparing the efficacy of CRP to a lack of CRP in patients with OPC. Results In total, 10 publications incorporating 888 patients were analyzed. Tumor-reducing prostatectomy was found to have no significant effect on long-term or short-term OS [OR = 2.26, 95% CI (0.97, 5.28), P = 0.06] and [OR = 1.73, 95% CI (0.83, 3.58), P = 0.14], but it significantly improved patient long-term or short-term CSS [OR = 1.77, 95% CI (1.01, 310), P = 0.04] and [OR = 2.71, 95% CI (1.72, 4.29), P < 0.0001] and PFS [OR = 1.93, 95% CI (1.25, 2.97), P = 0.003]. Conclusion These results suggest that cytoreductive prostatectomy can confer survival benefits to OPC patients. Trial registration INPLASY protocol 202260017 https://doi.org/10.37766/inplasy2022.6.0017 . |
| first_indexed | 2024-04-13T13:07:11Z |
| format | Article |
| id | doaj.art-2c0118a8cf2141aea59dfebca7d9d9b8 |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-04-13T13:07:11Z |
| publishDate | 2022-08-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-2c0118a8cf2141aea59dfebca7d9d9b82022-12-22T02:45:44ZengBMCWorld Journal of Surgical Oncology1477-78192022-08-0120111010.1186/s12957-022-02715-xCytoreductive prostatectomy improves survival outcomes in patients with oligometastases: a systematic meta-analysisYifeng Mao0Mingqiu Hu1Gaowei Yang2Erke Gao3Wangwang Xu4Department of Urology, The Second Affiliated Hospital of Bengbu Medical CollegeDepartment of Urology, The Second Affiliated Hospital of Bengbu Medical CollegeDepartment of Urology, Maoming People’s HospitalDepartment of Urology, Maoming People’s HospitalDepartment of Urology, Maoming People’s HospitalAbstract Background Whether cytoreductive prostatectomy (CRP) should be performed in patients with oligometastatic prostate cancer (OPC) remains controversial. The goal of this systematic meta-analysis was to assess the efficacy of CRP as a treatment for OPC. Methods This systematic review and meta-analysis was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis statement. Data sources included publications in the PubMed, Embase, the Cochrane Library, EBSCO, and Web of Science (SCI) databases as of May 2022. Eligible articles included prospective studies comparing the efficacy of CRP to a lack of CRP in patients with OPC. Results In total, 10 publications incorporating 888 patients were analyzed. Tumor-reducing prostatectomy was found to have no significant effect on long-term or short-term OS [OR = 2.26, 95% CI (0.97, 5.28), P = 0.06] and [OR = 1.73, 95% CI (0.83, 3.58), P = 0.14], but it significantly improved patient long-term or short-term CSS [OR = 1.77, 95% CI (1.01, 310), P = 0.04] and [OR = 2.71, 95% CI (1.72, 4.29), P < 0.0001] and PFS [OR = 1.93, 95% CI (1.25, 2.97), P = 0.003]. Conclusion These results suggest that cytoreductive prostatectomy can confer survival benefits to OPC patients. Trial registration INPLASY protocol 202260017 https://doi.org/10.37766/inplasy2022.6.0017 .https://doi.org/10.1186/s12957-022-02715-xCytoreductive prostatectomyOligometastasesOverall survivalCancer-specific survivalProgression-free survival |
| spellingShingle | Yifeng Mao Mingqiu Hu Gaowei Yang Erke Gao Wangwang Xu Cytoreductive prostatectomy improves survival outcomes in patients with oligometastases: a systematic meta-analysis World Journal of Surgical Oncology Cytoreductive prostatectomy Oligometastases Overall survival Cancer-specific survival Progression-free survival |
| title | Cytoreductive prostatectomy improves survival outcomes in patients with oligometastases: a systematic meta-analysis |
| title_full | Cytoreductive prostatectomy improves survival outcomes in patients with oligometastases: a systematic meta-analysis |
| title_fullStr | Cytoreductive prostatectomy improves survival outcomes in patients with oligometastases: a systematic meta-analysis |
| title_full_unstemmed | Cytoreductive prostatectomy improves survival outcomes in patients with oligometastases: a systematic meta-analysis |
| title_short | Cytoreductive prostatectomy improves survival outcomes in patients with oligometastases: a systematic meta-analysis |
| title_sort | cytoreductive prostatectomy improves survival outcomes in patients with oligometastases a systematic meta analysis |
| topic | Cytoreductive prostatectomy Oligometastases Overall survival Cancer-specific survival Progression-free survival |
| url | https://doi.org/10.1186/s12957-022-02715-x |
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