Excessive dietary Cr6+ had no adverse effect on mud crab (Scylla paramamosain) but provoke consumers health risk
Hexavalent chromium (Cr6+) is a metallic contaminant that in organisms and poses a great threat to biological health and ecology due to its toxicity and biomagnification. However, the potential health risks to mud crabs and humans from dietary excessive Cr6+ were currently unknown. Therefore, a 9-we...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Aquaculture Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352513422003933 |
| _version_ | 1797985325398622208 |
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| author | Yingying Zhang Jiaxiang Luo Tingting Zhu Zheng Yang Min Jin Lefei Jiao Qicun Zhou |
| author_facet | Yingying Zhang Jiaxiang Luo Tingting Zhu Zheng Yang Min Jin Lefei Jiao Qicun Zhou |
| author_sort | Yingying Zhang |
| collection | DOAJ |
| description | Hexavalent chromium (Cr6+) is a metallic contaminant that in organisms and poses a great threat to biological health and ecology due to its toxicity and biomagnification. However, the potential health risks to mud crabs and humans from dietary excessive Cr6+ were currently unknown. Therefore, a 9-week feeding trial was conducted to evaluate the toxic effects of dietary Cr6+ levels (1.4, 77.5 and 312.2 mg/kg) for mud crab (Scylla paramamosain). The results indicated that dietary Cr6+ levels had no significant effect on growth performance for mud crab. Cr concentrations in hepatopancreas and muscle significantly increased with dietary Cr6+ levels increasing from 1.4 to 312.2 mg/kg. The antioxidant capacity of mud crab was enhanced by increased the activities of superoxide dismutase (SOD) and scavenging capability for hydroxyl free radical (SCHR) to resist the Cr6+ toxicity. However, there was no statistical difference in the rate of apoptosis in hemocytes among all treatments. Expression levels of caspase 2 gene related to apoptosis in hemocytes significantly up-regulated with dietary Cr6+ level increasing from 1.4 to 312.2 mg/kg. For food safety, crabs fed diets with 77.5 and 312.2 mg/kg Cr6+ had target hazard quotient (THQ) values greater than 1 for the hepatopancreas, indicating a serious risk for human consumption. According to the target cancer risk (TCR) analysis, people who consumed muscle in mud crab fed diet with 312.2 mg/kg Cr6+ were at unacceptable cancer risk. Overall, the results of the present study indicated mud crab had a strong resistance to Cr6+ toxicity, and dietary excessive Cr6+ did not decline growth performance and survival, oxidative stress and apoptosis in mud crab. Excess Cr6+ were accumulated in tissues such as hepatopancreas and muscle, and consumption of crabs tissues fed diets with 77.5 and 312.2 mg/kg Cr6+ will provoke health and cancer risk in humans. |
| first_indexed | 2024-04-11T07:16:26Z |
| format | Article |
| id | doaj.art-2c013a7dbc9f4d04a9e8348ae7c64cd5 |
| institution | Directory Open Access Journal |
| issn | 2352-5134 |
| language | English |
| last_indexed | 2024-04-11T07:16:26Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Aquaculture Reports |
| spelling | doaj.art-2c013a7dbc9f4d04a9e8348ae7c64cd52022-12-22T04:37:56ZengElsevierAquaculture Reports2352-51342022-12-0127101397Excessive dietary Cr6+ had no adverse effect on mud crab (Scylla paramamosain) but provoke consumers health riskYingying Zhang0Jiaxiang Luo1Tingting Zhu2Zheng Yang3Min Jin4Lefei Jiao5Qicun Zhou6Laboratory of Fish and Shellfish Nutrition, School of Marine Sciences, Ningbo University, Ningbo 315211, China; Key Laboratory of Aquacultral Biotechnology Ministry of Education, Ningbo University, ChinaLaboratory of Fish and Shellfish Nutrition, School of Marine Sciences, Ningbo University, Ningbo 315211, China; Key Laboratory of Aquacultral Biotechnology Ministry of Education, Ningbo University, ChinaLaboratory of Fish and Shellfish Nutrition, School of Marine Sciences, Ningbo University, Ningbo 315211, China; Key Laboratory of Aquacultral Biotechnology Ministry of Education, Ningbo University, ChinaLaboratory of Fish and Shellfish Nutrition, School of Marine Sciences, Ningbo University, Ningbo 315211, China; Key Laboratory of Aquacultral Biotechnology Ministry of Education, Ningbo University, ChinaLaboratory of Fish and Shellfish Nutrition, School of Marine Sciences, Ningbo University, Ningbo 315211, China; Key Laboratory of Aquacultral Biotechnology Ministry of Education, Ningbo University, China; Corresponding authors at: Laboratory of Fish and Shellfish Nutrition, School of Marine Sciences, Ningbo University, Ningbo 315211, ChinaLaboratory of Fish and Shellfish Nutrition, School of Marine Sciences, Ningbo University, Ningbo 315211, China; Key Laboratory of Aquacultral Biotechnology Ministry of Education, Ningbo University, ChinaLaboratory of Fish and Shellfish Nutrition, School of Marine Sciences, Ningbo University, Ningbo 315211, China; Key Laboratory of Aquacultral Biotechnology Ministry of Education, Ningbo University, China; Corresponding authors at: Laboratory of Fish and Shellfish Nutrition, School of Marine Sciences, Ningbo University, Ningbo 315211, ChinaHexavalent chromium (Cr6+) is a metallic contaminant that in organisms and poses a great threat to biological health and ecology due to its toxicity and biomagnification. However, the potential health risks to mud crabs and humans from dietary excessive Cr6+ were currently unknown. Therefore, a 9-week feeding trial was conducted to evaluate the toxic effects of dietary Cr6+ levels (1.4, 77.5 and 312.2 mg/kg) for mud crab (Scylla paramamosain). The results indicated that dietary Cr6+ levels had no significant effect on growth performance for mud crab. Cr concentrations in hepatopancreas and muscle significantly increased with dietary Cr6+ levels increasing from 1.4 to 312.2 mg/kg. The antioxidant capacity of mud crab was enhanced by increased the activities of superoxide dismutase (SOD) and scavenging capability for hydroxyl free radical (SCHR) to resist the Cr6+ toxicity. However, there was no statistical difference in the rate of apoptosis in hemocytes among all treatments. Expression levels of caspase 2 gene related to apoptosis in hemocytes significantly up-regulated with dietary Cr6+ level increasing from 1.4 to 312.2 mg/kg. For food safety, crabs fed diets with 77.5 and 312.2 mg/kg Cr6+ had target hazard quotient (THQ) values greater than 1 for the hepatopancreas, indicating a serious risk for human consumption. According to the target cancer risk (TCR) analysis, people who consumed muscle in mud crab fed diet with 312.2 mg/kg Cr6+ were at unacceptable cancer risk. Overall, the results of the present study indicated mud crab had a strong resistance to Cr6+ toxicity, and dietary excessive Cr6+ did not decline growth performance and survival, oxidative stress and apoptosis in mud crab. Excess Cr6+ were accumulated in tissues such as hepatopancreas and muscle, and consumption of crabs tissues fed diets with 77.5 and 312.2 mg/kg Cr6+ will provoke health and cancer risk in humans.http://www.sciencedirect.com/science/article/pii/S2352513422003933Scylla paramamosainPotassium dichromateChromium accumulationHealth riskApoptosis |
| spellingShingle | Yingying Zhang Jiaxiang Luo Tingting Zhu Zheng Yang Min Jin Lefei Jiao Qicun Zhou Excessive dietary Cr6+ had no adverse effect on mud crab (Scylla paramamosain) but provoke consumers health risk Aquaculture Reports Scylla paramamosain Potassium dichromate Chromium accumulation Health risk Apoptosis |
| title | Excessive dietary Cr6+ had no adverse effect on mud crab (Scylla paramamosain) but provoke consumers health risk |
| title_full | Excessive dietary Cr6+ had no adverse effect on mud crab (Scylla paramamosain) but provoke consumers health risk |
| title_fullStr | Excessive dietary Cr6+ had no adverse effect on mud crab (Scylla paramamosain) but provoke consumers health risk |
| title_full_unstemmed | Excessive dietary Cr6+ had no adverse effect on mud crab (Scylla paramamosain) but provoke consumers health risk |
| title_short | Excessive dietary Cr6+ had no adverse effect on mud crab (Scylla paramamosain) but provoke consumers health risk |
| title_sort | excessive dietary cr6 had no adverse effect on mud crab scylla paramamosain but provoke consumers health risk |
| topic | Scylla paramamosain Potassium dichromate Chromium accumulation Health risk Apoptosis |
| url | http://www.sciencedirect.com/science/article/pii/S2352513422003933 |
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