Altered neural correlates of episodic memory in adolescents with severe obesity
Negative effects of obesity on memory and associated medial temporal circuitry have been noted in animal models, but the status in humans, particularly children, is not well established. Our study is the first to examine neural correlates of successful memory encoding of visual scenes and their asso...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-12-01
|
| Series: | Developmental Cognitive Neuroscience |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878929319303147 |
| _version_ | 1828914216016281600 |
|---|---|
| author | Alaina L Pearce Eleanor Mackey J. Bradley C. Cherry Alexandra Olson Xiaozhen You Evan P Nadler Chandan J Vaidya |
| author_facet | Alaina L Pearce Eleanor Mackey J. Bradley C. Cherry Alexandra Olson Xiaozhen You Evan P Nadler Chandan J Vaidya |
| author_sort | Alaina L Pearce |
| collection | DOAJ |
| description | Negative effects of obesity on memory and associated medial temporal circuitry have been noted in animal models, but the status in humans, particularly children, is not well established. Our study is the first to examine neural correlates of successful memory encoding of visual scenes and their associated context in adolescents with severe obesity (age 14–18 years, 43% male). Despite similar subsequent memory as adolescents without obesity (BMI for age and sex <95th percentile), those with severe obesity (BMI for age and sex 120% above the 95th percentile) showed reduced hippocampal, parahippocampal, frontal, and parietal engagement during encoding of remembered visual scenes and greater lateral temporal engagement during encoding of their associated context. Standardized testing revealed a trend level group difference in memory performance, with a larger magnitude of obesity-related difference in recollection-related memory that was mediated by individual differences in lateral temporal activation during contextual encoding. The observed widespread functional alterations are concerning in light of the importance of mnemonic processing for academic achievement and feeding behavior and underscore the need for prevention and intervention initiatives for pediatric obesity. Keywords: fMRI, WRAML, Declarative memory, Visual memory |
| first_indexed | 2024-12-13T19:50:17Z |
| format | Article |
| id | doaj.art-2c025cd8b84c437a9b77321a100ccf31 |
| institution | Directory Open Access Journal |
| issn | 1878-9293 |
| language | English |
| last_indexed | 2024-12-13T19:50:17Z |
| publishDate | 2019-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Developmental Cognitive Neuroscience |
| spelling | doaj.art-2c025cd8b84c437a9b77321a100ccf312022-12-21T23:33:26ZengElsevierDevelopmental Cognitive Neuroscience1878-92932019-12-0140Altered neural correlates of episodic memory in adolescents with severe obesityAlaina L Pearce0Eleanor Mackey1J. Bradley C. Cherry2Alexandra Olson3Xiaozhen You4Evan P Nadler5Chandan J Vaidya6Psychology, Georgetown University, Washington, DC, 20007, United States; Corresponding author at: Alaina Pearce and Chandan Vaidya, 401 White-Gravenor, 37thand O Streets NW, Washington, DC, United States.Children’s National Health System, Washington, DC, 20007, United States; Children’s Research Institute, Washington, DC, 20010, United StatesPsychology, Georgetown University, Washington, DC, 20007, United StatesChildren’s National Health System, Washington, DC, 20007, United StatesPsychology, Georgetown University, Washington, DC, 20007, United States; Children’s Research Institute, Washington, DC, 20010, United StatesChildren’s National Health System, Washington, DC, 20007, United States; Children’s Research Institute, Washington, DC, 20010, United StatesPsychology, Georgetown University, Washington, DC, 20007, United States; Children’s Research Institute, Washington, DC, 20010, United StatesNegative effects of obesity on memory and associated medial temporal circuitry have been noted in animal models, but the status in humans, particularly children, is not well established. Our study is the first to examine neural correlates of successful memory encoding of visual scenes and their associated context in adolescents with severe obesity (age 14–18 years, 43% male). Despite similar subsequent memory as adolescents without obesity (BMI for age and sex <95th percentile), those with severe obesity (BMI for age and sex 120% above the 95th percentile) showed reduced hippocampal, parahippocampal, frontal, and parietal engagement during encoding of remembered visual scenes and greater lateral temporal engagement during encoding of their associated context. Standardized testing revealed a trend level group difference in memory performance, with a larger magnitude of obesity-related difference in recollection-related memory that was mediated by individual differences in lateral temporal activation during contextual encoding. The observed widespread functional alterations are concerning in light of the importance of mnemonic processing for academic achievement and feeding behavior and underscore the need for prevention and intervention initiatives for pediatric obesity. Keywords: fMRI, WRAML, Declarative memory, Visual memoryhttp://www.sciencedirect.com/science/article/pii/S1878929319303147 |
| spellingShingle | Alaina L Pearce Eleanor Mackey J. Bradley C. Cherry Alexandra Olson Xiaozhen You Evan P Nadler Chandan J Vaidya Altered neural correlates of episodic memory in adolescents with severe obesity Developmental Cognitive Neuroscience |
| title | Altered neural correlates of episodic memory in adolescents with severe obesity |
| title_full | Altered neural correlates of episodic memory in adolescents with severe obesity |
| title_fullStr | Altered neural correlates of episodic memory in adolescents with severe obesity |
| title_full_unstemmed | Altered neural correlates of episodic memory in adolescents with severe obesity |
| title_short | Altered neural correlates of episodic memory in adolescents with severe obesity |
| title_sort | altered neural correlates of episodic memory in adolescents with severe obesity |
| url | http://www.sciencedirect.com/science/article/pii/S1878929319303147 |
| work_keys_str_mv | AT alainalpearce alteredneuralcorrelatesofepisodicmemoryinadolescentswithsevereobesity AT eleanormackey alteredneuralcorrelatesofepisodicmemoryinadolescentswithsevereobesity AT jbradleyccherry alteredneuralcorrelatesofepisodicmemoryinadolescentswithsevereobesity AT alexandraolson alteredneuralcorrelatesofepisodicmemoryinadolescentswithsevereobesity AT xiaozhenyou alteredneuralcorrelatesofepisodicmemoryinadolescentswithsevereobesity AT evanpnadler alteredneuralcorrelatesofepisodicmemoryinadolescentswithsevereobesity AT chandanjvaidya alteredneuralcorrelatesofepisodicmemoryinadolescentswithsevereobesity |