Bioconcentration and biotransformation of organophosphorus flame retardants (PFRs) in common carp (Cyprinus carpio)
Understanding the bioaccumulation and biotransformation of xenobiotic compounds is critical for evaluating their fate and potential toxicity in vivo. In the present study, the tissue specific accumulation and depuration of seven organophosphorus flame retardants (PFRs) in common carp (Cyprinus carpi...
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| Format: | Article |
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Elsevier
2019-05-01
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| Series: | Environment International |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412019300613 |
| _version_ | 1818906598171475968 |
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| author | Bin Tang Giulia Poma Michiel Bastiaensen Shan-Shan Yin Xiao-Jun Luo Bi-Xian Mai Adrian Covaci |
| author_facet | Bin Tang Giulia Poma Michiel Bastiaensen Shan-Shan Yin Xiao-Jun Luo Bi-Xian Mai Adrian Covaci |
| author_sort | Bin Tang |
| collection | DOAJ |
| description | Understanding the bioaccumulation and biotransformation of xenobiotic compounds is critical for evaluating their fate and potential toxicity in vivo. In the present study, the tissue specific accumulation and depuration of seven organophosphorus flame retardants (PFRs) in common carp (Cyprinus carpio) were investigated after exposing the fish to an environmental relevant level of PFRs. The log Kow of PFRs was significantly negatively correlated to the percentages of individual PFRs to the total PFRs in serum (p < 0.04), whereas significantly positive correlations were observed in all other tissues (p < 0.02). Significant correlations (p < 0.01) between the log Kow of PFRs and their log bioconcentration factor (BCFww) were also found in all investigated tissues except for serum. This suggests that the hydrophobicity of PFRs played a significant role in the distribution and body compartment accumulation of PFRs in common carp. The bioaccumulation potential of PFRs in serum was different from the other tissues, probably due to its specific properties. Dialkyl and/or diaryl phosphate esters (DAP) and hydroxylated PFRs (HO-PFRs) were quantified as the major metabolites. Their levels in liver and intestine were significantly higher than in other tissues. Biotransformation processes also played a crucial role in the accumulation of PFRs in fish. Our results provide critical information for further understanding the bioconcentration, tissue distribution and metabolism of PFRs in fish. Keywords: Organophosphorus flame retardants, Tissue-specific bioconcentration, Metabolites, Common carp |
| first_indexed | 2024-12-19T21:41:46Z |
| format | Article |
| id | doaj.art-2c05d9e5bce845b28a07d8b35beb4389 |
| institution | Directory Open Access Journal |
| issn | 0160-4120 |
| language | English |
| last_indexed | 2024-12-19T21:41:46Z |
| publishDate | 2019-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj.art-2c05d9e5bce845b28a07d8b35beb43892022-12-21T20:04:38ZengElsevierEnvironment International0160-41202019-05-01126512522Bioconcentration and biotransformation of organophosphorus flame retardants (PFRs) in common carp (Cyprinus carpio)Bin Tang0Giulia Poma1Michiel Bastiaensen2Shan-Shan Yin3Xiao-Jun Luo4Bi-Xian Mai5Adrian Covaci6State Key Laboratory of Organic Geochemistry, Guangdong Key Laboratory of Environmental Resources Utilization and Protection, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, PR China; Toxicological Centre, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium; University of Chinese Academy of Sciences, Beijing 100049, PR ChinaToxicological Centre, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, BelgiumToxicological Centre, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, BelgiumToxicological Centre, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, BelgiumState Key Laboratory of Organic Geochemistry, Guangdong Key Laboratory of Environmental Resources Utilization and Protection, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, PR China; Corresponding authors.State Key Laboratory of Organic Geochemistry, Guangdong Key Laboratory of Environmental Resources Utilization and Protection, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, PR ChinaToxicological Centre, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium; Corresponding authors.Understanding the bioaccumulation and biotransformation of xenobiotic compounds is critical for evaluating their fate and potential toxicity in vivo. In the present study, the tissue specific accumulation and depuration of seven organophosphorus flame retardants (PFRs) in common carp (Cyprinus carpio) were investigated after exposing the fish to an environmental relevant level of PFRs. The log Kow of PFRs was significantly negatively correlated to the percentages of individual PFRs to the total PFRs in serum (p < 0.04), whereas significantly positive correlations were observed in all other tissues (p < 0.02). Significant correlations (p < 0.01) between the log Kow of PFRs and their log bioconcentration factor (BCFww) were also found in all investigated tissues except for serum. This suggests that the hydrophobicity of PFRs played a significant role in the distribution and body compartment accumulation of PFRs in common carp. The bioaccumulation potential of PFRs in serum was different from the other tissues, probably due to its specific properties. Dialkyl and/or diaryl phosphate esters (DAP) and hydroxylated PFRs (HO-PFRs) were quantified as the major metabolites. Their levels in liver and intestine were significantly higher than in other tissues. Biotransformation processes also played a crucial role in the accumulation of PFRs in fish. Our results provide critical information for further understanding the bioconcentration, tissue distribution and metabolism of PFRs in fish. Keywords: Organophosphorus flame retardants, Tissue-specific bioconcentration, Metabolites, Common carphttp://www.sciencedirect.com/science/article/pii/S0160412019300613 |
| spellingShingle | Bin Tang Giulia Poma Michiel Bastiaensen Shan-Shan Yin Xiao-Jun Luo Bi-Xian Mai Adrian Covaci Bioconcentration and biotransformation of organophosphorus flame retardants (PFRs) in common carp (Cyprinus carpio) Environment International |
| title | Bioconcentration and biotransformation of organophosphorus flame retardants (PFRs) in common carp (Cyprinus carpio) |
| title_full | Bioconcentration and biotransformation of organophosphorus flame retardants (PFRs) in common carp (Cyprinus carpio) |
| title_fullStr | Bioconcentration and biotransformation of organophosphorus flame retardants (PFRs) in common carp (Cyprinus carpio) |
| title_full_unstemmed | Bioconcentration and biotransformation of organophosphorus flame retardants (PFRs) in common carp (Cyprinus carpio) |
| title_short | Bioconcentration and biotransformation of organophosphorus flame retardants (PFRs) in common carp (Cyprinus carpio) |
| title_sort | bioconcentration and biotransformation of organophosphorus flame retardants pfrs in common carp cyprinus carpio |
| url | http://www.sciencedirect.com/science/article/pii/S0160412019300613 |
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