Regional microglia are transcriptionally distinct but similarly exacerbate neurodegeneration in a culture model of Parkinson’s disease

Regional microglia are transcriptionally distinct but similarly exacerbate neurodegeneration in a culture model of Parkinson’s disease

Abstract Background Parkinson’s disease (PD) is characterized by selective degeneration of dopaminergic (DA) neurons of the substantia nigra pars compacta (SN) while neighboring ventral tegmental area (VTA) DA neurons are relatively spared. Mechanisms underlying the selective protection of the VTA a...

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Bibliographic Details
Main Authors: Eric Wildon Kostuk, Jingli Cai, Lorraine Iacovitti
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Journal of Neuroinflammation
Subjects:
Microglia
Astrocyte
Neuron
Parkinsons’ disease
Neurodegeneration
Online Access:http://link.springer.com/article/10.1186/s12974-018-1181-x

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