Experimental data suggesting that inflammation mediated rat liver mitochondrial dysfunction results from secondary hypoxia rather than from direct effects of inflammatory mediators

Experimental data suggesting that inflammation mediated rat liver mitochondrial dysfunction results from secondary hypoxia rather than from direct effects of inflammatory mediators

Systemic inflammatory response (SIR) comprises direct effects of inflammatory mediators (IM) and indirect effects, such as secondary circulatory failure which results in tissue hypoxia (HOX). These two key components, SIR and HOX, cause multiple organ failure (MOF). Since HOX and IM occur and intera...

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Bibliographic Details
Main Authors: Adelheid eWeidinger, Peter eDungel, Martin ePerlinger, Katharina eSinger, Corina eGhebes, Catharina eDuvigneau, Andrea eMüllebner, Ute eSchäfer, Heinz eRedl, Andrey V Kozlov
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-06-01
Series:Frontiers in Physiology
Subjects:
Liver
iNOS
lipopolysaccharide
cytokine
IL-6
reoxygenation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2013.00138/full

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