Comparative effect of deliberate hypotensive anesthesia using nitroglycerine vs. phentolamine on event related potentials and cognitive functions in patients undergoing septoplasty: a randomized controlled trial
Abstract Background Postoperative cognitive dysfunction is a noteworthy complication of deliberate hypotensive anesthesia. The aim of this work was to compare the effect of deliberate hypotensive anesthesia using nitroglycerine versus phentolamine on event-related potentials and cognitive function i...
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| Format: | Article |
| Language: | English |
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BMC
2023-05-01
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| Series: | BMC Anesthesiology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12871-023-02096-y |
| _version_ | 1797831940312662016 |
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| author | Wael Fathy Mona Hussein Rehab Magdy Hanan H Soliman Hatem Elmoutaz Alaa A Meshref Reem M Sabry Marwa A Elgaly Mohammed Fawaz Dina Y Kassim |
| author_facet | Wael Fathy Mona Hussein Rehab Magdy Hanan H Soliman Hatem Elmoutaz Alaa A Meshref Reem M Sabry Marwa A Elgaly Mohammed Fawaz Dina Y Kassim |
| author_sort | Wael Fathy |
| collection | DOAJ |
| description | Abstract Background Postoperative cognitive dysfunction is a noteworthy complication of deliberate hypotensive anesthesia. The aim of this work was to compare the effect of deliberate hypotensive anesthesia using nitroglycerine versus phentolamine on event-related potentials and cognitive function in patients undergoing septoplasty surgery. Methods This prospective randomized controlled trial was conducted on 80 patients indicated for septoplasty under general anesthesia; 40 patients received intra-operative Nitroglycerine and 40 patients received intra-operative Phentolamine. Cognitive assessment (using Paired Associate Learning test (PALT) and Benton Visual Retention test (BVRT)) and P300 recording were done for all included patients pre-operatively and one week postoperatively. Results The scores of PALT and Benton BVRT significantly declined one week following surgery in both Nitroglycerine and Phentolamine groups. There was no statistically significant difference between Nitroglycerine and Phentolamine groups in the postoperative decline in either PALT or BVRT (P-value = 0.342, 0.662 respectively). The values of P300 latency showed a significant delay one week following surgery in both Nitroglycerine and Phentolamine groups (P-value ≤ 0.001, 0.001), but in Nitroglycerine group, the delay is significantly higher than in Phentolamine group (P-value = 0.003). The values of P300 amplitude significantly decreased one week following surgery in both Nitroglycerine and Phentolamine groups (P-value ≤ 0.001, 0.001), but there was no statistically significant difference between Nitroglycerine and Phentolamine groups (P-value = 0.099). Conclusion Phentolamine is preferred over nitroglycerin in deliberate hypotensive anesthesia because it has less harmful effect on cognitive function than nitroglycerin. |
| first_indexed | 2024-04-09T13:59:43Z |
| format | Article |
| id | doaj.art-2c07de33d76644f3860b8c1c05296b0b |
| institution | Directory Open Access Journal |
| issn | 1471-2253 |
| language | English |
| last_indexed | 2024-04-09T13:59:43Z |
| publishDate | 2023-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Anesthesiology |
| spelling | doaj.art-2c07de33d76644f3860b8c1c05296b0b2023-05-07T11:21:55ZengBMCBMC Anesthesiology1471-22532023-05-012311810.1186/s12871-023-02096-yComparative effect of deliberate hypotensive anesthesia using nitroglycerine vs. phentolamine on event related potentials and cognitive functions in patients undergoing septoplasty: a randomized controlled trialWael Fathy0Mona Hussein1Rehab Magdy2Hanan H Soliman3Hatem Elmoutaz4Alaa A Meshref5Reem M Sabry6Marwa A Elgaly7Mohammed Fawaz8Dina Y Kassim9Department of Anesthesia, Surgical ICU and Pain management, Beni-Suef UniversityDepartment of Neurology, Beni-Suef UniversityDepartment of Neurology, Cairo UniversityNeuro diagnostic research center, Beni-Suef UniversityDepartment of Anesthesia, Surgical ICU and Pain management, Beni-Suef UniversityNeuro diagnostic research center, Beni-Suef UniversityNeuro diagnostic research center, Beni-Suef UniversityNeuro diagnostic research center, Beni-Suef UniversityDepartment of Otorhinolaryngology, Beni-Suef UniversityDepartment of Anesthesia, Surgical ICU and Pain management, Beni-Suef UniversityAbstract Background Postoperative cognitive dysfunction is a noteworthy complication of deliberate hypotensive anesthesia. The aim of this work was to compare the effect of deliberate hypotensive anesthesia using nitroglycerine versus phentolamine on event-related potentials and cognitive function in patients undergoing septoplasty surgery. Methods This prospective randomized controlled trial was conducted on 80 patients indicated for septoplasty under general anesthesia; 40 patients received intra-operative Nitroglycerine and 40 patients received intra-operative Phentolamine. Cognitive assessment (using Paired Associate Learning test (PALT) and Benton Visual Retention test (BVRT)) and P300 recording were done for all included patients pre-operatively and one week postoperatively. Results The scores of PALT and Benton BVRT significantly declined one week following surgery in both Nitroglycerine and Phentolamine groups. There was no statistically significant difference between Nitroglycerine and Phentolamine groups in the postoperative decline in either PALT or BVRT (P-value = 0.342, 0.662 respectively). The values of P300 latency showed a significant delay one week following surgery in both Nitroglycerine and Phentolamine groups (P-value ≤ 0.001, 0.001), but in Nitroglycerine group, the delay is significantly higher than in Phentolamine group (P-value = 0.003). The values of P300 amplitude significantly decreased one week following surgery in both Nitroglycerine and Phentolamine groups (P-value ≤ 0.001, 0.001), but there was no statistically significant difference between Nitroglycerine and Phentolamine groups (P-value = 0.099). Conclusion Phentolamine is preferred over nitroglycerin in deliberate hypotensive anesthesia because it has less harmful effect on cognitive function than nitroglycerin.https://doi.org/10.1186/s12871-023-02096-yDeliberate hypotensive anesthesiaNitroglycerinePhentolaminePALTBVRTP300 |
| spellingShingle | Wael Fathy Mona Hussein Rehab Magdy Hanan H Soliman Hatem Elmoutaz Alaa A Meshref Reem M Sabry Marwa A Elgaly Mohammed Fawaz Dina Y Kassim Comparative effect of deliberate hypotensive anesthesia using nitroglycerine vs. phentolamine on event related potentials and cognitive functions in patients undergoing septoplasty: a randomized controlled trial BMC Anesthesiology Deliberate hypotensive anesthesia Nitroglycerine Phentolamine PALT BVRT P300 |
| title | Comparative effect of deliberate hypotensive anesthesia using nitroglycerine vs. phentolamine on event related potentials and cognitive functions in patients undergoing septoplasty: a randomized controlled trial |
| title_full | Comparative effect of deliberate hypotensive anesthesia using nitroglycerine vs. phentolamine on event related potentials and cognitive functions in patients undergoing septoplasty: a randomized controlled trial |
| title_fullStr | Comparative effect of deliberate hypotensive anesthesia using nitroglycerine vs. phentolamine on event related potentials and cognitive functions in patients undergoing septoplasty: a randomized controlled trial |
| title_full_unstemmed | Comparative effect of deliberate hypotensive anesthesia using nitroglycerine vs. phentolamine on event related potentials and cognitive functions in patients undergoing septoplasty: a randomized controlled trial |
| title_short | Comparative effect of deliberate hypotensive anesthesia using nitroglycerine vs. phentolamine on event related potentials and cognitive functions in patients undergoing septoplasty: a randomized controlled trial |
| title_sort | comparative effect of deliberate hypotensive anesthesia using nitroglycerine vs phentolamine on event related potentials and cognitive functions in patients undergoing septoplasty a randomized controlled trial |
| topic | Deliberate hypotensive anesthesia Nitroglycerine Phentolamine PALT BVRT P300 |
| url | https://doi.org/10.1186/s12871-023-02096-y |
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